Regulation of Autophagy by Glycolysis in Cancer.
autophagy
glycolysis
lactate
lung cancer
metabolism
Journal
Cancer management and research
ISSN: 1179-1322
Titre abrégé: Cancer Manag Res
Pays: New Zealand
ID NLM: 101512700
Informations de publication
Date de publication:
2020
2020
Historique:
received:
31
08
2020
accepted:
28
10
2020
entrez:
31
12
2020
pubmed:
1
1
2021
medline:
1
1
2021
Statut:
epublish
Résumé
Autophagy is a critical cellular process that generally protects cells and organisms from harsh environment, including limitations in adenosine triphosphate (ATP) availability or a lack of essential nutrients. Metabolic reprogramming, a hallmark of cancer, has recently gained interest in the area of cancer therapy. It is well known that cancer cells prefer to utilize glycolysis rather than oxidative phosphorylation (OXPHOS) as their major energy source to rapidly generate ATP even in aerobic environment called the Warburg effect. Both autophagy and glycolysis play essential roles in pathological processes of cancer. A mechanism of metabolic changes to drive tumor progression is its ability to regulate autophagy. This review will elucidate the role and the mechanism of glycolysis in regulating autophagy during tumor growth. Indeed, understanding how glycolysis can modulate cellular autophagy will enable more effective combinatorial therapeutic strategies.
Identifiants
pubmed: 33380833
doi: 10.2147/CMAR.S279672
pii: 279672
pmc: PMC7767644
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
13259-13271Informations de copyright
© 2020 Chu et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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