Fisetin Regulates Gut Microbiota and Exerts Neuroprotective Effect on Mouse Model of Parkinson's Disease.
Parkinson’s disease
biomarker
fisetin
gut microbiota
neuroprotective
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
04
2020
accepted:
19
11
2020
entrez:
31
12
2020
pubmed:
1
1
2021
medline:
1
1
2021
Statut:
epublish
Résumé
Previous studies have reported the anti-oxidant, anti-inflammatory, and anti-cancer effects of fisetin. However, the therapeutic efficacy of fisetin in Parkinson's disease (PD) is unclear. In this study, we demonstrated that fisetin could markedly alleviate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in mice. To confirm the reported correlation between gut microbiota and PD, the bacterial DNA in the fresh feces of mice from each group was subjected to 16S rRNA (V3 and V4 regions) sequencing. The results revealed that fisetin changed the number, diversity, and distribution of gut microbiota in MPTP-induced mice model of PD. The alpha and beta diversity analyses showed that the fisetin intervented MPTP group gut microbiota exhibited a significantly higher abundance of Lachnospiraceae and a significantly lower abundance of uncultured_bacterium_g_Escherichia-Shigella and uncultured_bacterium_g_Bacillus than the MPTP group gut microbiota. These findings indicated that fisetin exerts a neuroprotective effect on neurodegeneration by altering the composition and diversity of gut microbiota. Thus, fisetin could be a potential novel therapeutic for PD.
Identifiants
pubmed: 33381005
doi: 10.3389/fnins.2020.549037
pmc: PMC7768012
doi:
Types de publication
Journal Article
Langues
eng
Pagination
549037Informations de copyright
Copyright © 2020 Chen, Feng, Liu, Wu, Chen, Li, Li and Wu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Front Cell Infect Microbiol. 2015 Apr 08;5:33
pubmed: 25905048
J Cell Mol Med. 2019 Feb;23(2):1095-1105
pubmed: 30411496
Cancer Lett. 2015 Oct 28;367(2):173-83
pubmed: 26235140
Toxins (Basel). 2019 Apr 09;11(4):
pubmed: 30970547
Bioinformatics. 2010 Oct 1;26(19):2460-1
pubmed: 20709691
Parkinsonism Relat Disord. 2017 May;38:61-67
pubmed: 28259623
Physiol Rev. 2019 Oct 1;99(4):1877-2013
pubmed: 31460832
J Mol Biol. 2018 Oct 12;430(20):3657-3684
pubmed: 30009771
EBioMedicine. 2019 Jun;44:691-707
pubmed: 31221587
Nat Methods. 2010 May;7(5):335-6
pubmed: 20383131
Int Rev Neurobiol. 2017;134:787-809
pubmed: 28805583
Parkinsonism Relat Disord. 2018 Aug;53:82-88
pubmed: 29776865
Mol Neurobiol. 2017 Apr;54(3):2269-2285
pubmed: 26944285
J Parkinsons Dis. 2012;2(4):287-302
pubmed: 23938259
Sci Transl Med. 2014 Nov 19;6(263):263ra158
pubmed: 25411471
Brain Behav Immun. 2018 May;70:48-60
pubmed: 29471030
J Diet Suppl. 2021;18(1):57-71
pubmed: 31992104
Clin Sci (Lond). 2016 Dec 1;130(23):2199-2207
pubmed: 27634868
Parkinsonism Relat Disord. 2016 Nov;32:66-72
pubmed: 27591074
Biochem Pharmacol. 2012 Nov 15;84(10):1277-81
pubmed: 22842629
Cell Mol Neurobiol. 2019 Aug;39(6):809-822
pubmed: 31037516
J Nutr Biochem. 2019 Jul;69:73-86
pubmed: 31063918
Neurosci Lett. 2006 Mar 20;396(1):67-72
pubmed: 16330147
Nat Neurosci. 2017 Feb;20(2):145-155
pubmed: 28092661
Nat Rev Neurosci. 2017 Jul;18(7):435-450
pubmed: 28592904
Elife. 2020 Feb 11;9:
pubmed: 32043464
Lancet Neurol. 2015 Jun;14(6):625-39
pubmed: 25987282
Mov Disord. 2017 May;32(5):739-749
pubmed: 28195358
Mov Disord. 2015 Sep;30(10):1351-60
pubmed: 26179554
Lancet. 2015 Aug 29;386(9996):896-912
pubmed: 25904081
Brain Behav Immun. 2020 Nov;90:26-46
pubmed: 32739365
Neurosci Biobehav Rev. 2016 Jun;65:63-94
pubmed: 27026638
Res Commun Chem Pathol Pharmacol. 1985 Dec;50(3):435-41
pubmed: 3878557
J Neurosurg. 1994 Jan;80(1):58-63
pubmed: 8271023
Nat Neurosci. 2015 Jul;18(7):965-77
pubmed: 26030851
Sci China Life Sci. 2017 Nov;60(11):1223-1233
pubmed: 28536926
Cell. 2016 Dec 1;167(6):1469-1480.e12
pubmed: 27912057
Food Funct. 2017 Sep 20;8(9):3033-3042
pubmed: 28714503
Aging (Albany NY). 2019 Sep 3;11(17):6915-6929
pubmed: 31479418
J Neurosci Methods. 2012 Jan 30;203(2):292-7
pubmed: 22015600
BMC Genomics. 2013 Oct 01;14:669
pubmed: 24083370
Sci Rep. 2017 Feb 08;7:41802
pubmed: 28176819
J Neuroinflammation. 2016 Apr 07;13(1):74
pubmed: 27055651
Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1691-6
pubmed: 22307632
Mov Disord. 2015 Mar;30(3):350-8
pubmed: 25476529
Appl Environ Microbiol. 2002 Oct;68(10):5186-90
pubmed: 12324374
Sci Rep. 2016 Oct 06;6:34477
pubmed: 27708338
Neuron. 2016 May 18;90(4):675-91
pubmed: 27196972
Appl Environ Microbiol. 2000 Apr;66(4):1654-61
pubmed: 10742256