Translation initiation and its relevance in colorectal cancer.
RNA translation
colorectal cancer
protein synthesis
translation initiation
translational control
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
22
12
2020
received:
05
10
2020
accepted:
29
12
2020
pubmed:
1
1
2021
medline:
21
12
2021
entrez:
31
12
2020
Statut:
ppublish
Résumé
Protein synthesis is one of the most essential processes in every kingdom of life, and its dysregulation is a known driving force in cancer development. Multiple signaling pathways converge on the translation initiation machinery, and this plays a crucial role in regulating differential gene expression. In colorectal cancer, dysregulation of initiation results in translational reprogramming, which promotes the selective translation of mRNAs required for many oncogenic processes. The majority of upstream mutations found in colorectal cancer, including alterations in the WNT, MAPK, and PI3K\AKT pathways, have been demonstrated to play a significant role in translational reprogramming. Many translation initiation factors are also known to be dysregulated, resulting in translational reprogramming during tumor initiation and/or maintenance. In this review, we outline the role of translational reprogramming that occurs during colorectal cancer development and progression and highlight some of the most critical factors affecting the etiology of this disease.
Identifiants
pubmed: 33382175
doi: 10.1111/febs.15690
pmc: PMC9291299
doi:
Substances chimiques
Peptide Initiation Factors
0
RNA, Messenger
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
6635-6651Informations de copyright
© 2021 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
Références
Mol Cell Biol. 2018 May 29;38(12):
pubmed: 29610153
Curr Genomics. 2007 Mar;8(1):43-9
pubmed: 18645623
Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3260-5
pubmed: 10737792
Mol Cell Biol. 1993 Dec;13(12):7358-63
pubmed: 8246956
Nat Rev Genet. 2018 Jul;19(7):431-452
pubmed: 29725087
Nature. 2019 Sep;573(7775):605-608
pubmed: 31534220
Biochim Biophys Acta. 1989 Dec 22;1009(3):297-300
pubmed: 2597680
Cell Death Dis. 2019 Jun 26;10(7):504
pubmed: 31243264
Cell Rep. 2013 Apr 25;3(4):1128-39
pubmed: 23545496
Oncogene. 1999 Apr 15;18(15):2507-17
pubmed: 10229202
Science. 2016 Jan 29;351(6272):aad3867
pubmed: 26823435
Biochem J. 1995 Nov 15;312 ( Pt 1):163-7
pubmed: 7492307
Mol Oncol. 2018 Nov;12(11):1856-1870
pubmed: 30221473
Int J Med Sci. 2019 Aug 6;16(8):1132-1141
pubmed: 31523176
EMBO J. 1997 Apr 15;16(8):1909-20
pubmed: 9155017
Nat Rev Cancer. 2010 Apr;10(4):301-9
pubmed: 20332779
Nat Med. 2015 Nov;21(11):1350-6
pubmed: 26457759
Annu Rev Biochem. 2019 Jun 20;88:307-335
pubmed: 31220979
Br J Cancer. 2019 Jul;121(1):37-50
pubmed: 31133691
Cell Death Differ. 2018 Mar;25(3):616-633
pubmed: 29305587
Histochem J. 2000 Mar;32(3):139-50
pubmed: 10841309
Trends Cell Biol. 2016 Dec;26(12):918-933
pubmed: 27426745
Cell Rep. 2020 May 5;31(5):107611
pubmed: 32375039
Nat Commun. 2020 May 19;11(1):2498
pubmed: 32427827
J Clin Invest. 2012 Dec;122(12):4621-34
pubmed: 23143306
Endocr Rev. 2001 Apr;22(2):153-83
pubmed: 11294822
Nat Cell Biol. 2019 Jul;21(7):889-899
pubmed: 31263264
Biochim Biophys Acta. 2015 Nov;1849(11):1313-8
pubmed: 26381322
Oncotarget. 2012 Feb;3(2):118-31
pubmed: 22392765
J Biol Chem. 2010 Sep 17;285(38):29033-8
pubmed: 20576611
Cell Cycle. 2009 Nov 15;8(22):3684-7
pubmed: 19855161
Biochim Biophys Acta. 2015 Jul;1849(7):871-80
pubmed: 25497381
Bioorg Med Chem. 2019 Apr 1;27(7):1211-1225
pubmed: 30824167
Nucleic Acids Res. 2014 Oct 29;42(19):12052-69
pubmed: 25260592
Elife. 2017 Mar 18;6:
pubmed: 28315520
Clin Cancer Res. 2018 Sep 1;24(17):4256-4270
pubmed: 29844128
Mol Cell. 2010 Oct 22;40(2):228-37
pubmed: 20965418
Genes Dev. 2001 Nov 1;15(21):2852-64
pubmed: 11691836
Carcinogenesis. 2002 Jan;23(1):201-5
pubmed: 11756242
Oncotarget. 2017 Sep 5;8(60):101224-101243
pubmed: 29254159
Oncogene. 2000 Mar 9;19(11):1437-47
pubmed: 10723135
Genes Dev. 1991 Nov;5(11):2108-16
pubmed: 1682219
Nature. 2000 Jan 20;403(6767):332-5
pubmed: 10659855
Cancer Discov. 2015 Jul;5(7):768-781
pubmed: 25934076
Cell. 1988 Jan 29;52(2):185-95
pubmed: 3277717
Sci Rep. 2019 Mar 1;9(1):3210
pubmed: 30824833
EMBO J. 1999 Jan 4;18(1):270-9
pubmed: 9878069
EMBO Rep. 2016 Oct;17(10):1374-1395
pubmed: 27629041
Mol Cell Biol. 2008 Jan;28(1):40-9
pubmed: 17967896
Cell. 2007 Oct 5;131(1):174-87
pubmed: 17923096
Nature. 2007 Apr 5;446(7136):676-9
pubmed: 17377531
Cancer Res. 2019 Sep 1;79(17):4348-4359
pubmed: 31292158
Clin Colorectal Cancer. 2018 Jun;17(2):e331-e352
pubmed: 29526493
Genome Biol. 2014;15(10):476
pubmed: 25273840
Genes Dev. 2004 Aug 15;18(16):1926-45
pubmed: 15314020
Mol Cell. 2003 Mar;11(3):619-33
pubmed: 12667446
Science. 2019 May 3;364(6439):491-495
pubmed: 31048491
Curr Opin Cell Biol. 2009 Jun;21(3):435-43
pubmed: 19243929
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6175-8
pubmed: 8327497
Cold Spring Harb Perspect Biol. 2013 Feb 01;5(2):
pubmed: 22767671
Nature. 2017 Jan 26;541(7638):494-499
pubmed: 28077873
Nat Rev Mol Cell Biol. 2020 Apr;21(4):183-203
pubmed: 31937935
Mol Cancer Ther. 2016 Dec;15(12):3055-3063
pubmed: 27913706
Mol Biosyst. 2015 Oct;11(10):2680-9
pubmed: 26259698
Nat Rev Genet. 2012 Jun;13(6):383-94
pubmed: 22568971
Cancer Metastasis Rev. 2012 Jun;31(1-2):387-95
pubmed: 22418835
Mol Cell. 2000 Aug;6(2):269-79
pubmed: 10983975
Cell. 2009 Feb 20;136(4):731-45
pubmed: 19239892
Cell. 1990 Jun 1;61(5):759-67
pubmed: 2188735
Biochem Biophys Res Commun. 2018 Sep 18;503(4):2286-2292
pubmed: 29959920
Front Biosci. 2008 May 01;13:4258-75
pubmed: 18508509
Nature. 2008 Dec 18;456(7224):971-5
pubmed: 19011615
Cell. 2016 Apr 21;165(3):535-50
pubmed: 27104977
Mol Cell Biol. 1996 Nov;16(11):6573-81
pubmed: 8887686
Mol Cells. 2010 Oct;30(4):285-93
pubmed: 21052925
Anticancer Res. 2010 Apr;30(4):1047-55
pubmed: 20530408
Microbiol Mol Biol Rev. 2011 Sep;75(3):434-67, first page of table of contents
pubmed: 21885680
Science. 2016 Jan 15;351(6270):
pubmed: 26816383
Cell. 2017 Mar 9;168(6):960-976
pubmed: 28283069
Nat Cell Biol. 2019 Nov;21(11):1413-1424
pubmed: 31685988
Int J Mol Sci. 2019 Oct 28;20(21):
pubmed: 31661924
Nat Rev Mol Cell Biol. 2011 Apr;12(4):235-45
pubmed: 21427765
Cancer Metastasis Rev. 2018 Mar;37(1):173-187
pubmed: 29322354
Annu Rev Biochem. 1999;68:913-63
pubmed: 10872469
Cancer Res. 2015 Jan 15;75(2):250-63
pubmed: 25593033
Nat Rev Cancer. 2016 Apr 26;16(5):288-304
pubmed: 27112207
Int J Cancer. 1996 Mar 15;65(6):785-90
pubmed: 8631593
Nat Rev Cancer. 2013 Jan;13(1):11-26
pubmed: 23258168
World J Surg Oncol. 2018 Dec 22;16(1):240
pubmed: 30579335
Nat Rev Drug Discov. 2015 Apr;14(4):261-78
pubmed: 25743081
Nucleic Acids Res. 2017 Nov 16;45(20):11821-11836
pubmed: 29040683
Oncogene. 2002 Dec 12;21(57):8741-8
pubmed: 12483527
J Pathol. 2013 Sep;231(1):63-76
pubmed: 23836465
Oncogene. 2015 Apr 16;34(16):2032-42
pubmed: 24909168
Science. 2015 Jun 26;348(6242):1486-8
pubmed: 26113725
Adv Nutr. 2012 May 01;3(3):307-21
pubmed: 22585904
J Mol Cell Biol. 2019 Oct 25;11(10):911-919
pubmed: 31504667
Annu Rev Pathol. 2011;6:479-507
pubmed: 21090969
Cancer Discov. 2021 May;11(5):1228-1247
pubmed: 33328217
Curr Opin Genet Dev. 2018 Feb;48:82-88
pubmed: 29153484
J Biol Chem. 1997 Dec 19;272(51):32061-6
pubmed: 9405401
Onco Targets Ther. 2016 Feb 19;9:815-22
pubmed: 26929650
Cancer Biol Ther. 2009 Aug;8(15):1463-9
pubmed: 19483468
Nat Genet. 2008 May;40(5):623-30
pubmed: 18372905
Science. 2016 Jun 17;352(6292):1413-6
pubmed: 27313038
Genes Dev. 2005 Jan 1;19(1):104-13
pubmed: 15630022
Science. 2011 Nov 25;334(6059):1081-6
pubmed: 22116877
Cell. 2012 Jun 8;149(6):1192-205
pubmed: 22682243
Curr Colorectal Cancer Rep. 2017 Apr;13(2):101-110
pubmed: 28413363
J Exp Clin Cancer Res. 2019 May 14;38(1):196
pubmed: 31088567
Am J Pathol. 2002 Aug;161(2):439-47
pubmed: 12163369
Neoplasma. 2017;64(5):787-794
pubmed: 28592131
Pathol Res Pract. 2017 May;213(5):490-495
pubmed: 28242042
Nature. 2014 Sep 4;513(7516):65-70
pubmed: 25079319
Genomics. 2001 Mar 15;72(3):223-30
pubmed: 11401437
Nat Commun. 2019 May 13;10(1):2136
pubmed: 31086188
Int J Biochem Cell Biol. 1999 Jan;31(1):107-22
pubmed: 10216947
Nat Rev Cancer. 2014 Sep;14(9):581-97
pubmed: 25145482
Cancer. 2003 Sep 1;98(5):1080-8
pubmed: 12942578
Front Biosci. 2008 May 01;13:5359-73
pubmed: 18508592
Nat Rev Cancer. 2010 Apr;10(4):254-66
pubmed: 20332778
Cell. 2015 Jul 2;162(1):59-71
pubmed: 26095252
Science. 2013 Nov 15;342(6160):1240585
pubmed: 24200810
World J Gastroenterol. 2014 Jan 28;20(4):943-56
pubmed: 24574767
Oncotarget. 2016 Dec 20;7(51):85502-85514
pubmed: 27907907
Oncogene. 2017 Mar;36(11):1461-1473
pubmed: 27617575
Microbiol Mol Biol Rev. 2011 Mar;75(1):50-83
pubmed: 21372320
Nucleic Acids Res. 2005 Nov 28;33(20):6593-602
pubmed: 16314320
Nature. 2012 Jul 18;487(7407):330-7
pubmed: 22810696
Lancet Oncol. 2011 Jun;12(6):594-603
pubmed: 21163703
Nature. 2015 Jan 22;517(7535):497-500
pubmed: 25383520
Int J Clin Exp Pathol. 2014 Sep 15;7(10):6462-74
pubmed: 25400724
Gene. 2015 Oct 25;571(2):286-91
pubmed: 26149657
Sci Transl Med. 2018 May 2;10(439):
pubmed: 29720449
EBioMedicine. 2019 Jun;44:387-402
pubmed: 31175057
Nature. 2011 May 19;473(7347):337-42
pubmed: 21593866
Nucleic Acids Res. 1984 May 11;12(9):3873-93
pubmed: 6328442
Gene. 2019 Jan 5;680:59-64
pubmed: 30243936
Mol Oncol. 2014 Dec;8(8):1482-94
pubmed: 24962791
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Cell Stem Cell. 2020 Jun 4;26(6):845-861.e12
pubmed: 32396863
Nat Struct Mol Biol. 2012 Jun 05;19(6):568-76
pubmed: 22664984
Biochem Soc Trans. 2015 Dec;43(6):1227-33
pubmed: 26614665
Biochim Biophys Acta. 2015 Jul;1849(7):766-73
pubmed: 25450520
Curr Hematol Malig Rep. 2019 Aug;14(4):219-227
pubmed: 31231778
Oncotarget. 2015 Sep 15;6(27):24092-104
pubmed: 26204490
Nat Rev Mol Cell Biol. 2010 Feb;11(2):113-27
pubmed: 20094052
Cancer Epidemiol Biomarkers Prev. 2001 Jun;10(6):663-6
pubmed: 11401917
Genes Dev. 2005 Jul 1;19(13):1556-71
pubmed: 15998809
Mol Cell. 2009 Aug 28;35(4):511-22
pubmed: 19716794
Trends Biochem Sci. 2017 Aug;42(8):589-611
pubmed: 28442192
Physiol Rev. 1999 Jan;79(1):143-80
pubmed: 9922370
Genes Dev. 2003 May 1;17(9):1115-29
pubmed: 12695333
Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1429-1437
pubmed: 31900355
Science. 1997 Mar 21;275(5307):1784-7
pubmed: 9065401
J Biol Chem. 1997 Oct 17;272(42):26457-63
pubmed: 9334222
Nat Rev Mol Cell Biol. 2009 May;10(5):307-18
pubmed: 19339977
Trends Biochem Sci. 2018 Nov;43(11):882-895
pubmed: 29789219
Trends Endocrinol Metab. 2017 Nov;28(11):794-806
pubmed: 28797581
Science. 2010 Nov 5;330(6005):835-838
pubmed: 21051640
Cancer Res. 2013 Oct 15;73(20):6099-105
pubmed: 24097826
Oncogene. 2004 Apr 19;23(18):3189-99
pubmed: 15094768