Characterization and Differentiation of the Tumor Microenvironment (TME) of Orthotopic and Subcutaneously Grown Head and Neck Squamous Cell Carcinoma (HNSCC) in Immunocompetent Mice.
Animals
B-Lymphocytes
/ immunology
Biomarkers
Bone Marrow
/ metabolism
Cell Line, Tumor
Disease Models, Animal
Disease Susceptibility
Immunocompromised Host
Immunotherapy
/ methods
Leukocyte Count
Lymph Nodes
/ metabolism
Lymphocyte Count
Lymphocytes, Tumor-Infiltrating
/ immunology
Mice
Squamous Cell Carcinoma of Head and Neck
/ immunology
T-Lymphocyte Subsets
/ immunology
Tumor Microenvironment
/ immunology
CD4+ T cells
SCC VII orthotopic mouse model
SCC VII subcutaneous mouse model
adenosine-related immunosuppression
head and neck cancer
regulatory B cells
tumor microenvironment
tumor-infiltrating lymphocytes
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Dec 2020
29 Dec 2020
Historique:
received:
10
11
2020
revised:
20
12
2020
accepted:
24
12
2020
entrez:
1
1
2021
pubmed:
2
1
2021
medline:
30
3
2021
Statut:
epublish
Résumé
For the development and evaluation of new head and neck squamous cell carcinoma (HNSCC) therapeutics, suitable, well-characterized animal models are needed. Thus, by analyzing orthotopic versus subcutaneous models of HNSCC in immunocompetent mice, we evaluated the existence of adenosine-related immunosuppressive B- and T lymphocyte populations within the tumor microenvironment (TME). Applying the SCC VII model for the induction of HNSCC in immunocompetent C3H/HeN mice, the cellular TME was characterized after tumor initiation over time by flow cytometry. The TME in orthotopic grown tumors revealed a larger population of tumor-infiltrating lymphocytes (TIL) with more B cells and CD4
Identifiants
pubmed: 33383676
pii: ijms22010247
doi: 10.3390/ijms22010247
pmc: PMC7796118
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Mod Pathol. 1997 Nov;10(11):1128-33
pubmed: 9388064
Cancer Res. 2009 Apr 1;69(7):3105-13
pubmed: 19318560
Semin Immunol. 2008 Feb;20(1):26-42
pubmed: 18243731
Oral Oncol. 2009 Apr-May;45(4-5):309-16
pubmed: 18804401
Head Neck. 2001 Oct;23(10):899-906
pubmed: 11592238
Cell Immunol. 2019 Sep;343:103713
pubmed: 29129292
Cancer Discov. 2016 Mar;6(3):270-85
pubmed: 26715645
Otolaryngol Head Neck Surg. 2005 Feb;132(2):309-16
pubmed: 15692546
Cancer Res. 2000 Dec 15;60(24):6811-7
pubmed: 11156370
Immunol Res. 2013 Dec;57(1-3):52-69
pubmed: 24218361
J Exp Med. 1998 Oct 5;188(7):1287-95
pubmed: 9763608
Science. 2011 Mar 25;331(6024):1565-70
pubmed: 21436444
Int J Cancer. 2006 May 1;118(9):2111-22
pubmed: 16380986
N Engl J Med. 2016 Nov 10;375(19):1856-1867
pubmed: 27718784
Cancer Immunol Immunother. 2020 Jul;69(7):1205-1216
pubmed: 32146518
Cancer Immunol Immunother. 2016 Apr;65(4):393-403
pubmed: 26899388
BMC Cancer. 2009 Aug 22;9:292
pubmed: 19698134
J Immunother Cancer. 2016 Jul 19;4:40
pubmed: 27437104
N Engl J Med. 1986 Dec 25;315(26):1650-9
pubmed: 3537791
J Immunol. 2005 Oct 15;175(8):5541-50
pubmed: 16210663
Mayo Clin Proc. 2008 Apr;83(4):489-501
pubmed: 18380996
Expert Opin Biol Ther. 2013 Sep;13(9):1241-56
pubmed: 23789839
J Pharmacol Toxicol Methods. 2011 May-Jun;63(3):236-49
pubmed: 21156211
Oral Oncol. 2019 Mar;90:67-73
pubmed: 30846179
Arch Otolaryngol Head Neck Surg. 1997 Jan;123(1):20-4
pubmed: 9006499
Arch Immunol Ther Exp (Warsz). 2018 Apr;66(2):113-123
pubmed: 29032490
Cell. 2000 Oct 27;103(3):481-90
pubmed: 11081634
Oral Oncol. 2009 Oct;45(10):e167-74
pubmed: 19576838
Clin Cancer Res. 2006 Jan 15;12(2):465-72
pubmed: 16428488
Int J Radiat Oncol Biol Phys. 1984 Aug;10(8):1473-8
pubmed: 6206039
Clin Exp Otorhinolaryngol. 2009 Jun;2(2):55-60
pubmed: 19565028
J Immunol. 2010 Nov 1;185(9):4977-82
pubmed: 20962266
Cancer Res. 1990 Apr 15;50(8):2290-5
pubmed: 2317817
Mol Cancer. 2010 Jan 10;9:4
pubmed: 20064222
Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13132-7
pubmed: 16916931
J Allergy Clin Immunol. 2016 Sep;138(3):654-665
pubmed: 27596706
Arch Otolaryngol Head Neck Surg. 2007 Dec;133(12):1263-9
pubmed: 18086970
Semin Immunol. 2005 Aug;17(4):273-83
pubmed: 15953735
Cancer Lett. 2012 Apr 28;317(2):199-206
pubmed: 22123294
Cancer Res. 2013 Jan 1;73(1):128-38
pubmed: 23135914
J Immunol. 2010 Apr 1;184(7):4006-16
pubmed: 20194720
Int J Exp Pathol. 2003 Dec;84(6):259-65
pubmed: 14748745
Cancer Res. 2009 Mar 15;69(6):2523-30
pubmed: 19244121
J Immunol. 2006 Nov 15;177(10):6780-6
pubmed: 17082591
Cancer Res. 2003 Jul 1;63(13):3675-81
pubmed: 12839958
Clin Cancer Res. 2008 Jun 15;14(12):3706-15
pubmed: 18559587
Clin Cancer Res. 2004 Jun 1;10(11):3755-62
pubmed: 15173082
Oral Oncol. 2017 Feb;65:51-56
pubmed: 28109468