Aging of Bone Marrow Mesenchymal Stromal Cells: Hematopoiesis Disturbances and Potential Role in the Development of Hematologic Cancers.
aging
bone marrow niche
hematologic malignancies
hematopoiesis
inflammaging
inflammation
mesenchymal stromal cells
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
29 Dec 2020
29 Dec 2020
Historique:
received:
16
11
2020
revised:
16
12
2020
accepted:
24
12
2020
entrez:
1
1
2021
pubmed:
2
1
2021
medline:
2
1
2021
Statut:
epublish
Résumé
Aging of bone marrow is a complex process that is involved in the development of many diseases, including hematologic cancers. The results obtained in this field of research, year after year, underline the important role of cross-talk between hematopoietic stem cells and their close environment. In bone marrow, mesenchymal stromal cells (MSCs) are a major player in cell-to-cell communication, presenting a wide range of functionalities, sometimes opposite, depending on the environmental conditions. Although these cells are actively studied for their therapeutic properties, their role in tumor progression remains unclear. One of the reasons for this is that the aging of MSCs has a direct impact on their behavior and on hematopoiesis. In addition, tumor progression is accompanied by dynamic remodeling of the bone marrow niche that may interfere with MSC functions. The present review presents the main features of MSC senescence in bone marrow and their implications in hematologic cancer progression.
Identifiants
pubmed: 33383723
pii: cancers13010068
doi: 10.3390/cancers13010068
pmc: PMC7794884
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Sci Rep. 2019 Jan 31;9(1):1056
pubmed: 30705326
Nat Commun. 2018 Jun 1;9(1):2143
pubmed: 29858571
Cell Death Dis. 2018 May 3;9(5):512
pubmed: 29724992
J Immunol. 2015 Sep 15;195(6):2666-74
pubmed: 26268654
Cytotherapy. 2018 Dec;20(12):1419-1426
pubmed: 30352735
Blood. 2009 Aug 27;114(9):1803-12
pubmed: 19597185
J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9
pubmed: 24833586
Cell Res. 2016 Feb;26(2):190-205
pubmed: 26768768
Leuk Lymphoma. 2007 Oct;48(10):2032-41
pubmed: 17917971
Front Oncol. 2020 Feb 25;10:230
pubmed: 32161723
Cell Stem Cell. 2008 Feb 7;2(2):141-50
pubmed: 18371435
Aging Cell. 2004 Dec;3(6):379-89
pubmed: 15569355
Br J Haematol. 1996 Jan;92(1):97-103
pubmed: 8562418
EMBO J. 2017 Apr 3;36(7):840-853
pubmed: 28254837
Semin Immunol. 2018 Dec;40:17-35
pubmed: 30287177
Cancer Res. 2018 Jan 1;78(1):129-142
pubmed: 29066511
Leukemia. 2016 Sep;30(9):1938-42
pubmed: 27109510
Aging Dis. 2019 Feb 01;10(1):174-189
pubmed: 30705777
Inflamm Res. 2019 Feb;68(2):167-176
pubmed: 30426152
Cytotherapy. 2009;11(5):584-94
pubmed: 19626496
Blood. 2011 Dec 15;118(25):6506-14
pubmed: 21979940
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Arch Immunol Ther Exp (Warsz). 2016 Apr;64(2):111-26
pubmed: 26658771
J Exp Med. 1994 May 1;179(5):1677-82
pubmed: 7513014
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Clin Cancer Res. 2012 Jan 15;18(2):342-9
pubmed: 22065077
J Exp Clin Cancer Res. 2009 Nov 03;28:141
pubmed: 19883517
Cell Stem Cell. 2014 Jun 5;14(6):824-37
pubmed: 24704494
Cancer Res. 2004 Dec 1;64(23):8492-5
pubmed: 15574751
Blood. 1998 Apr 1;91(7):2387-96
pubmed: 9516138
Front Oncol. 2020 Aug 19;10:1422
pubmed: 32974152
Mech Ageing Dev. 2020 Jul;189:111279
pubmed: 32526214
Cell Discov. 2018 Jan 23;4:4
pubmed: 29423272
EMBO Mol Med. 2013 Mar;5(3):430-40
pubmed: 23364955
Stem Cells Dev. 2014 Dec 15;23(24):2972-82
pubmed: 25055118
Exp Hematol. 2009 Dec;37(12):1445-53
pubmed: 19772890
Haematologica. 2015 May;100(5):571-4
pubmed: 25944637
Int J Hematol. 2016 Sep;104(3):358-67
pubmed: 27272942
Haematologica. 2020 Jan;105(1):22-37
pubmed: 31806687
J Cell Physiol. 2019 Jun;234(6):8249-8258
pubmed: 30378105
Aging (Albany NY). 2018 May 19;10(5):1103-1132
pubmed: 29779019
Genes Dev. 2008 Nov 1;22(21):2941-52
pubmed: 18981473
Biomolecules. 2020 Feb 21;10(2):
pubmed: 32098040
Mol Cancer. 2015 Jan 27;14:14
pubmed: 25623255
Int J Radiat Biol. 2012 May;88(5):393-404
pubmed: 22348537
PLoS One. 2008 May 21;3(5):e2213
pubmed: 18493317
Stem Cells. 2019 Feb;37(2):240-246
pubmed: 30412645
Oncotarget. 2016 Apr 19;7(16):21713-27
pubmed: 26967055
Leuk Res. 2017 Jun;57:20-26
pubmed: 28273548
Matrix Biol. 2019 Jan;75-76:27-42
pubmed: 29066153
Mol Med Rep. 2017 Sep;16(3):2497-2504
pubmed: 28677723
CA Cancer J Clin. 2020 Jan;70(1):7-30
pubmed: 31912902
Blood. 2012 Mar 15;119(11):2500-9
pubmed: 22289892
J Bone Miner Res. 2008 Jul;23(7):1118-28
pubmed: 18435580
Exp Gerontol. 2018 May;105:27-31
pubmed: 29054535
PLoS One. 2011 May 10;6(5):e19503
pubmed: 21572997
Rejuvenation Res. 2016 Mar 15;19(5):351-361
pubmed: 26650116
Leukemia. 2007 Feb;21(2):304-10
pubmed: 17170725
Int J Med Sci. 2014 Sep 13;11(11):1201-7
pubmed: 25249788
Hematology. 2018 Jul;23(6):337-345
pubmed: 29140182
Nature. 2014 Jan 16;505(7483):327-34
pubmed: 24429631
Int J Mol Sci. 2020 Jan 17;21(2):
pubmed: 31963513
Exp Gerontol. 2016 Sep;82:39-49
pubmed: 27235851
Nature. 2003 Oct 23;425(6960):836-41
pubmed: 14574412
Mech Ageing Dev. 2008 Mar;129(3):163-73
pubmed: 18241911
PLoS One. 2008 Jun 25;3(6):e2563
pubmed: 18575622
Haematologica. 2010 Jul;95(7):1081-9
pubmed: 20179085
Trans Am Clin Climatol Assoc. 2013;124:230-7
pubmed: 23874029
Acta Biochim Biophys Sin (Shanghai). 2017 Mar 1;49(3):208-215
pubmed: 28177455
Haematologica. 2012 Feb;97(2):179-83
pubmed: 21993672
Int J Mol Sci. 2016 Aug 26;17(9):
pubmed: 27571072
Haematologica. 2012 Apr;97(4):608-15
pubmed: 22058221
Stem Cells. 2014 Aug;32(8):2256-66
pubmed: 24659476
Stem Cells Dev. 2018 May 1;27(9):579-589
pubmed: 29649408
Stem Cell Investig. 2017 Dec 19;4:98
pubmed: 29359137
Elife. 2014 Sep 25;3:e03696
pubmed: 25255216
Tissue Cell. 2015 Jun;47(3):229-34
pubmed: 25779671
Exp Cell Res. 1965 Mar;37:614-36
pubmed: 14315085
J Pathol. 2019 Feb;247(2):241-253
pubmed: 30357841
Cancer. 2001 Apr 1;91(7):1219-30
pubmed: 11283920
Cell Stem Cell. 2017 Jun 1;20(6):771-784.e6
pubmed: 28330582
Haematologica. 2010 Apr;95(4):651-9
pubmed: 20179086
Leuk Res. 2015 Jan;39(1):92-9
pubmed: 25443862
Arch Immunol Ther Exp (Warsz). 2008 May-Jun;56(3):207-21
pubmed: 18512025
Stem Cells. 2004;22(5):675-82
pubmed: 15342932
Blood. 2014 Jul 24;124(4):555-66
pubmed: 24928860
Front Immunol. 2018 Apr 09;9:586
pubmed: 29686666
BMC Cancer. 2015 Feb 18;15:68
pubmed: 25886144
Nature. 2007 Oct 4;449(7162):557-63
pubmed: 17914389
J Bone Miner Metab. 2011 Mar;29(2):224-35
pubmed: 20811759
Sci Rep. 2014 Nov 21;4:7144
pubmed: 25413454
Cancer Biol Ther. 2014 Oct;15(10):1413-22
pubmed: 25046247
Panminerva Med. 1961 Feb;3:64-6
pubmed: 13733973
Cytotherapy. 2006;8(4):315-7
pubmed: 16923606
Oncotarget. 2015 Apr 10;6(10):7632-43
pubmed: 25544766
Mol Cancer Ther. 2008 Jan;7(1):48-58
pubmed: 18202009
Leukemia. 2014 Nov;28(11):2241-4
pubmed: 24943834
Blood. 2011 May 12;117(19):5067-77
pubmed: 21415267
J Hematother Stem Cell Res. 2000 Dec;9(6):841-8
pubmed: 11177595
Cell Transplant. 2017 Sep;26(9):1520-1529
pubmed: 29113463
Haematologica. 2012 Aug;97(8):1218-24
pubmed: 22371183
Immunity. 2011 Apr 22;34(4):590-601
pubmed: 21458307
Science. 1999 Apr 2;284(5411):143-7
pubmed: 10102814
Med J Malaysia. 2010 Sep;65(3):209-14
pubmed: 21939170
Stem Cell Res Ther. 2017 Jun 24;8(1):153
pubmed: 28646912
Leukemia. 2009 May;23(5):925-33
pubmed: 19148141
Aging Cell. 2018 Aug;17(4):e12794
pubmed: 29896785
Leukemia. 2013 Sep;27(9):1841-51
pubmed: 23797473
Cytotherapy. 2009;11(2):114-28
pubmed: 19242838
Stem Cells Dev. 2013 May 1;22(9):1329-41
pubmed: 23249221
Cancers (Basel). 2020 Nov 02;12(11):
pubmed: 33147765
Tissue Eng Part A. 2017 Nov;23(21-22):1231-1240
pubmed: 28363268
BMB Rep. 2020 Feb;53(2):65-73
pubmed: 31964472
Haematologica. 2017 Sep;102(9):1594-1604
pubmed: 28596280
Stem Cells. 2017 Jan;35(1):3-8
pubmed: 27647718
PLoS One. 2016 Feb 02;11(2):e0146722
pubmed: 26836120
Stem Cells Dev. 2007 Dec;16(6):921-30
pubmed: 17927494
Stem Cells Int. 2019 Aug 1;2019:5197983
pubmed: 31467563
Aging Cell. 2010 Feb;9(1):54-63
pubmed: 19895632
PLoS One. 2013;8(3):e59756
pubmed: 23555770
Cancer Lett. 2012 Apr 28;317(2):136-43
pubmed: 22240014
Cell. 2002 Jan 11;108(1):17-29
pubmed: 11792318
Haematologica. 2020 Jun 05;105(9):e470-473
pubmed: 33054066
Leukemia. 2019 Feb;33(2):536-541
pubmed: 30315231
Blood. 2015 Aug 27;126(9):1106-17
pubmed: 26100252
PLoS One. 2010 Jun 16;5(6):e11140
pubmed: 20585401
J Cell Biochem. 2006 Dec 1;99(5):1233-9
pubmed: 16795049
Int J Mol Med. 2015 Jul;36(1):139-49
pubmed: 25901937
Stem Cells. 2009 Aug;27(8):1887-98
pubmed: 19544445
J Exp Med. 2005 Jun 6;201(11):1781-91
pubmed: 15928197
Ann Hematol. 2016 Jan;95(2):173-8
pubmed: 26555286
Blood. 2014 Apr 24;123(17):2691-702
pubmed: 24599548
Cell Stem Cell. 2019 May 2;24(5):769-784.e6
pubmed: 30905620
Eur Cell Mater. 2016 Feb 08;31:136-59
pubmed: 26853623
Stem Cell Reports. 2014 Dec 9;3(6):965-74
pubmed: 25454633
J Pathol. 2020 Apr;250(5):555-572
pubmed: 31608444
Aging (Albany NY). 2019 Sep 29;11(18):7996-8014
pubmed: 31575829
Theranostics. 2017 Jul 6;7(10):2673-2689
pubmed: 28819455
Oncotarget. 2015 Nov 24;6(37):39482-92
pubmed: 26498687
Oxid Med Cell Longev. 2019 Apr 17;2019:4915149
pubmed: 31178962
Ann Oncol. 2007 Jan;18 Suppl 1:i3-i8
pubmed: 17311819
Curr Opin Immunol. 2014 Aug;29:86-92
pubmed: 24905894
Blood. 2009 Nov 12;114(20):4441-50
pubmed: 19762485
Aging (Albany NY). 2020 Mar 11;12(5):4052-4066
pubmed: 32160592
J Clin Invest. 2017 Apr 3;127(4):1241-1253
pubmed: 28240601
Aging Cell. 2008 Jun;7(3):335-43
pubmed: 18248663
Stem Cell Reports. 2018 Jan 9;10(1):166-179
pubmed: 29290626
PLoS One. 2010 Apr 26;5(4):e10088
pubmed: 20436665
Stem Cells. 2018 Mar;36(3):420-433
pubmed: 29230885
Oncotarget. 2016 Mar 22;7(12):13285-96
pubmed: 26934440
Lab Invest. 2012 Sep;92(9):1330-41
pubmed: 22710983
Cell Stem Cell. 2014 Apr 3;14(4):445-459
pubmed: 24561084
Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10119-10124
pubmed: 28864530
Cell Physiol Biochem. 2010;26(6):799-808
pubmed: 21220911
Leukemia. 2019 Mar;33(3):597-611
pubmed: 30705410
PLoS One. 2018 Dec 26;13(12):e0209606
pubmed: 30586456
Calcif Tissue Int. 2002 Jul;71(1):36-44
pubmed: 12200657
Leukemia. 2007 Jan;21(1):158-63
pubmed: 17096013
World J Stem Cells. 2019 Jun 26;11(6):337-346
pubmed: 31293716
Stem Cells. 2014 Jul;32(7):1865-77
pubmed: 24496748
J Immunol. 2009 Jun 15;182(12):7963-73
pubmed: 19494321
J Mol Med (Berl). 2012 Apr;90(4):389-400
pubmed: 22038097
Br J Haematol. 2017 Jun;177(5):818-822
pubmed: 27102230
Aging Cell. 2019 Jun;18(3):e12933
pubmed: 30828977
J Clin Invest. 2010 Oct;120(10):3455-65
pubmed: 20877012
Genome Res. 2015 Jan;25(1):27-40
pubmed: 25271306
Indian J Hematol Blood Transfus. 2019 Apr;35(2):223-232
pubmed: 30988556
Ann Hematol. 2012 Aug;91(8):1175-86
pubmed: 22395436
World J Stem Cells. 2014 Nov 26;6(5):526-39
pubmed: 25426250
Mol Cancer. 2010 Jul 06;9:176
pubmed: 20604947
Stem Cells Int. 2016;2016:6493241
pubmed: 27042183
Stem Cell Reports. 2020 Aug 11;15(2):317-325
pubmed: 32649902
Leukemia. 2007 May;21(5):1079-88
pubmed: 17344918
Eur J Haematol. 2014 Dec;93(6):476-86
pubmed: 24889123
Int J Mol Sci. 2020 Mar 05;21(5):
pubmed: 32151085
Inflamm Regen. 2020 Nov 5;40(1):29
pubmed: 33292805
PLoS One. 2014 Aug 04;9(8):e102426
pubmed: 25090227