The investigation of bone fracture healing under intramembranous and endochondral ossification.
Bone fracture healing
Endochondral ossification
Intramembranous ossification
Locking compression plate
Mechano-regulation
Titanium
Journal
Bone reports
ISSN: 2352-1872
Titre abrégé: Bone Rep
Pays: United States
ID NLM: 101646176
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
07
08
2020
revised:
07
12
2020
accepted:
11
12
2020
entrez:
1
1
2021
pubmed:
2
1
2021
medline:
2
1
2021
Statut:
epublish
Résumé
After trauma, fractured bone starts healing directly through bone union or indirectly through callus formation process. Intramembranous and endochondral ossification are two commonly known mechanisms of indirect healing. The present study investigated the bone fracture healing under intramembranous and endochondral ossification by developing theoretical models in conjunction with performing a series of animal experiments. Using experimentally determined mean bone densities in sheep tibia stabilized by the Locking Compression Plate (LCP) fixation system, the research outcomes showed that intramembranous and endochondral ossification can be described by Hill Function with two unique sets of function parameters in mechanical stimuli mediated fracture healing. Two different thresholds exist within the range of mechanical simulation index which could trigger significant intramembranous and endochondral ossification, with a relatively higher bone formation rate of endochondral ossification than that of intramembranous ossification. Furthermore, the increase of flexibility of the LCP system and the use of titanium LCP could potentially promote uniform bone formation across the fracture gap, ultimately better healing outcomes.
Identifiants
pubmed: 33385019
doi: 10.1016/j.bonr.2020.100740
pii: S2352-1872(20)30500-3
pmc: PMC7772545
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100740Informations de copyright
© 2020 The Authors.
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