The core circadian component, Bmal1, is maintained in the pineal gland of old killifish brain.
Biological Sciences
Chronobiology
Molecular Biology
Physiology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
22 Jan 2021
22 Jan 2021
Historique:
received:
20
04
2020
revised:
05
10
2020
accepted:
03
12
2020
entrez:
1
1
2021
pubmed:
2
1
2021
medline:
2
1
2021
Statut:
epublish
Résumé
Circadian rhythm is altered during aging, although the underlying molecular mechanisms remain largely unknown. Here, we used the turquoise killifish as a short-lived vertebrate model to examine the effects of aging on the major circadian network comprising the four mammalian clock protein homologs, Bmal1, Clockb, Cry1b, and Per3, which are highly conserved in the killifish with 50%-85% amino acid sequence identity to their human counterparts. The amplitude of circadian rhythm was smaller in old fish (14 weeks) than in young fish (6 weeks). In old fish brain, the Bmal1 protein level was significantly downregulated. However, the Bmal1 interaction with Clockb and chromatin binding of Bmal1 to its downstream target promoters were retained. Furthermore, Bmal1 was relatively well maintained in the pineal gland compared with other regions of the old fish brain. The results suggest that the circadian clock system in the killifish becomes spatially confined to the pineal gland upon aging.
Identifiants
pubmed: 33385110
doi: 10.1016/j.isci.2020.101905
pii: S2589-0042(20)31102-0
pmc: PMC7770606
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101905Informations de copyright
© 2020 The Author(s).
Déclaration de conflit d'intérêts
The authors have no competing interests to declare.
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