Focus on renal blood flow in mechanically ventilated patients with SARS-CoV-2: a prospective pilot study.
ARDS
Acute kidney injury
COVID-19
Coronavirus
Mechanical ventilation
Renal resistivity index
SARS-CoV-2
Journal
Journal of clinical monitoring and computing
ISSN: 1573-2614
Titre abrégé: J Clin Monit Comput
Pays: Netherlands
ID NLM: 9806357
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
29
07
2020
accepted:
09
12
2020
pubmed:
2
1
2021
medline:
9
3
2022
entrez:
1
1
2021
Statut:
ppublish
Résumé
Mechanically ventilated patients with ARDS due to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) seem particularly susceptible to AKI. Our hypothesis was that the renal blood flow could be more compromised in SARS-CoV-2 patients than in patients with "classical" ARDS. We compared the renal resistivity index (RRI) and the renal venous flow (RVF) in ARDS patients with SARS-CoV-2 and in ARDS patients due to other etiologies. Prospective, observational pilot study performed on 30 mechanically ventilated patients (15 with SARS-COV-2 ARDS and 15 with ARDS). Mechanical ventilation settings included constant-flow controlled ventilation, a tidal volume of 6 ml/kg of ideal body weight and the PEEP level titrated to the lowest driving pressure. Ultrasound Doppler measurements of RRI and RVF pattern were performed in each patient. Patients with SARS-COV-2 ARDS had higher RRI than patients with ARDS (0.71[0.67-0.78] vs 0.64[0.60-0.74], p = 0.04). RVF was not-continuous in 9/15 patients (71%) in the SARS-COV-2 ARDS group and in and 5/15 (33%) in the ARDS group (p = 0.27). A linear correlation was found between PEEP and RRI in patients with SARS-COV-2 ARDS (r
Identifiants
pubmed: 33385260
doi: 10.1007/s10877-020-00633-5
pii: 10.1007/s10877-020-00633-5
pmc: PMC7775615
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
161-167Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature.
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