The transient outward potassium current plays a key role in spiral wave breakup in ventricular tissue.

Action Potentials Animals Arrhythmias, Cardiac / etiology Calcium Channels, L-Type / metabolism Calcium Signaling Computer Simulation Guinea Pigs Heart Rate Heart Ventricles / metabolism Humans Kinetics Models, Cardiovascular Myocytes, Cardiac / metabolism Potassium / metabolism Potassium Channels / metabolism Rabbits
action potential model spiral wave breakup transient outward potassium current ventricular arrhythmias

Journal

American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228

Informations de publication

Date de publication:
01 02 2021
Historique:
pubmed: 2 1 2021
medline: 23 3 2021
entrez: 1 1 2021
Statut: ppublish

Résumé

Spiral wave reentry as a mechanism of lethal ventricular arrhythmias has been widely demonstrated in animal experiments and recordings from human hearts. It has been shown that in structurally normal hearts spiral waves are unstable, breaking up into multiple wavelets via dynamical instabilities. However, many of the second-generation action potential models give rise only to stable spiral waves, raising issues regarding the underlying mechanisms of spiral wave breakup. In this study, we carried out computer simulations of two-dimensional homogeneous tissues using five ventricular action potential models. We show that the transient outward potassium current (

Identifiants

DOI: 10.1152/ajpheart.00608.2020 PMID: 33385322 PMC: PMC8082802
pubmed: 33385322
doi: 10.1152/ajpheart.00608.2020
pmc: PMC8082802
doi:

Substances chimiques

Calcium Channels, L-Type 0
Potassium Channels 0
Potassium RWP5GA015D

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

H826-H837

Subventions

Organisme : NHLBI NIH HHS
ID : F30 HL140864
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134709
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139829
Pays : United States

Références

Circ Res. 1991 Jun;68(6):1501-26
pubmed: 1709839
Am J Cardiol. 1988 Jan 15;61(2):2A-8A
pubmed: 3276123
Circ Res. 2000 Dec 8;87(12):1103-7
pubmed: 11110766
Circulation. 2004 Nov 16;110(20):3168-74
pubmed: 15505083
Phys Rev Lett. 1993 Aug 16;71(7):1103-1106
pubmed: 10055449
Circulation. 1998 Nov 24;98(21):2334-51
pubmed: 9826323
JACC Clin Electrophysiol. 2017 Dec 26;3(13):1565-1576
pubmed: 29759839
Proc Natl Acad Sci U S A. 2000 May 23;97(11):6061-6
pubmed: 10811880
Biophys J. 2000 May;78(5):2392-404
pubmed: 10777735
Biophys J. 2015 Apr 21;108(8):1908-21
pubmed: 25902431
Circulation. 2006 Aug 8;114(6):530-2
pubmed: 16894047
Chaos. 1998 Mar;8(1):57-64
pubmed: 12779710
PLoS One. 2009;4(3):e4738
pubmed: 19270753
Circ Res. 2001 Aug 17;89(4):E30
pubmed: 11509455
Cardiovasc Res. 1996 Sep;32(3):593-603
pubmed: 8881520
Nature. 1998 Mar 5;392(6671):75-8
pubmed: 9510249
Heart Rhythm. 2020 Sep;17(9):1582-1590
pubmed: 32333974
Circulation. 2002 Oct 1;106(14):1859-66
pubmed: 12356642
Circulation. 1996 Jan 1;93(1):168-77
pubmed: 8616924
Circ Res. 1994 Jun;74(6):1071-96
pubmed: 7514509
Am J Physiol. 1998 Nov;275(5):H1635-42
pubmed: 9815071
Am J Physiol Heart Circ Physiol. 2001 Jun;280(6):H2689-96
pubmed: 11356625
PLoS One. 2014 Jan 08;9(1):e84401
pubmed: 24416228
Biophys J. 2004 Sep;87(3):1507-25
pubmed: 15345532
Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E3036-E3044
pubmed: 29531045
J Am Coll Cardiol. 2006 May 16;47(10):2074-85
pubmed: 16697328
Circulation. 1995 May 1;91(9):2454-69
pubmed: 7729033
Europace. 2014 Mar;16(3):458-65
pubmed: 24569901
Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H43-55
pubmed: 16997886
Ann Biomed Eng. 2000 Jul;28(7):755-71
pubmed: 11016413
J Physiol. 2020 Jul;598(14):2847-2873
pubmed: 30771223
Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2803-12
pubmed: 15271669
Chaos. 1994 Sep;4(3):461-472
pubmed: 12780121
Circ Res. 2002 May 3;90(8):889-96
pubmed: 11988490
Chaos. 2002 Sep;12(3):852-892
pubmed: 12779613
J Mol Cell Cardiol. 2010 Jan;48(1):112-21
pubmed: 19835882
Circulation. 2004 Oct 12;110(15):2110-8
pubmed: 15466637
Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1573-89
pubmed: 14656705
Biophys J. 2009 Feb 18;96(4):1264-74
pubmed: 19217846
J Physiol. 1977 Jun;268(1):177-210
pubmed: 874889
Am J Physiol. 1999 Jan;276(1):H269-83
pubmed: 9887041
Circ Res. 2000 Nov 24;87(11):1026-33
pubmed: 11090548
Annu Rev Physiol. 2015;77:29-55
pubmed: 25340965
Circulation. 1993 Dec;88(6):2903-15
pubmed: 8252704
Biophys J. 2008 Jan 15;94(2):392-410
pubmed: 18160660
J Cardiovasc Electrophysiol. 2003 Jun;14(6):621-31
pubmed: 12875424
Heart Rhythm. 2006 Mar;3(3):345-52
pubmed: 16500310
Circ Res. 2001 Dec 7;89(12):1216-23
pubmed: 11739288
Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2561-2
pubmed: 17308010
Circ Res. 2002 Feb 8;90(2):213-22
pubmed: 11834715
Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2589-97
pubmed: 17259437
J Cardiovasc Electrophysiol. 1996 Jun;7(6):503-11
pubmed: 8743756
Circ Arrhythm Electrophysiol. 2017 Dec;10(12):
pubmed: 29247034
J Physiol. 2004 Sep 1;559(Pt 2):593-609
pubmed: 15243136
Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1935-41
pubmed: 16632545
PLoS Comput Biol. 2019 Aug 8;15(8):e1007260
pubmed: 31393876
MethodsX. 2016 Dec 23;4:25-34
pubmed: 28116246
J Gen Physiol. 1999 Apr;113(4):581-600
pubmed: 10102938
Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H262-9
pubmed: 22037192
Circ Res. 2000 Jan 7-21;86(1):86-93
pubmed: 10625309
Phys Rev Lett. 2017 Mar 31;118(13):138101
pubmed: 28409990
J Mol Cell Cardiol. 2016 Jul;96:72-81
pubmed: 26385634
Jpn Circ J. 2000 Aug;64(8):602-5
pubmed: 10952157
Heart Rhythm. 2016 Oct;13(10):e295-324
pubmed: 27423412
Circ Arrhythm Electrophysiol. 2011 Oct;4(5):692-703
pubmed: 21750274
Nature. 1992 Jan 23;355(6358):349-51
pubmed: 1731248
Circ Res. 2002 Aug 23;91(4):339-45
pubmed: 12193467
J Cardiovasc Electrophysiol. 2002 Nov;13(11):1141-9
pubmed: 12475106
Chaos. 1996 Dec;6(4):579-600
pubmed: 12780289
Biophys J. 2010 May 19;98(10):2091-101
pubmed: 20483316
Circulation. 2001 Nov 27;104(22):2728-33
pubmed: 11723027
Ann Biomed Eng. 1994 Nov-Dec;22(6):592-609
pubmed: 7872570
Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H2296-308
pubmed: 12003840
PLoS Comput Biol. 2010 Sep 02;6(9):e1000914
pubmed: 20824123
PLoS Comput Biol. 2011 May;7(5):e1002061
pubmed: 21637795
Biophys J. 2008 Jan 15;94(2):411-23
pubmed: 18160661
Circulation. 2006 Aug 8;114(6):536-42
pubmed: 16880326
Circ Arrhythm Electrophysiol. 2015 Jun;8(3):694-702
pubmed: 25772542
Chaos. 1998 Mar;8(1):20-47
pubmed: 12779708
Circ Res. 1998 Jun 15;82(11):1206-23
pubmed: 9633920
Science. 1995 Nov 17;270(5239):1222-3; author reply 1224-5
pubmed: 7502055
Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1088-100
pubmed: 16565318
Phys Rev E. 2018 Apr;97(4-1):042414
pubmed: 29758700
Am J Physiol Heart Circ Physiol. 2001 Feb;280(2):H535-45
pubmed: 11158949
Heart Rhythm. 2015 Aug;12(8):1852-66
pubmed: 25869754

Auteurs

Julian Landaw (J)

Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California.
Department of Computational Medicine, David Geffen School of Medicine, University of California, Los Angeles, California.

Xiaoping Yuan (X)

Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California.
Information Engineering School, Hangzhou Dianzi University, Hangzhou, People's Republic of China.

Peng-Sheng Chen (PS)

Cedars-Sinai Medical Center, Los Angeles, California.
ORCID: 0000-0002-4150-5836

Zhilin Qu (Z)

Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California.
Department of Computational Medicine, David Geffen School of Medicine, University of California, Los Angeles, California.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › The transient outward potassium current plays...
questionsmedicales.fr › Eucaryotes › Animaux › The transient outward potassium current plays...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › The transient outward potassium current plays...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canaux calciques de type L › The transient outward potassium current plays...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › The transient outward potassium current plays...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › The transient outward potassium current plays...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Cochons d'Inde › The transient outward potassium current plays...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Rythme cardiaque › The transient outward potassium current plays...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Ventricules cardiaques › The transient outward potassium current plays...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The transient outward potassium current plays...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › The transient outward potassium current plays...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles cardiovasculaires › The transient outward potassium current plays...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › The transient outward potassium current plays...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Potassium › The transient outward potassium current plays...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › The transient outward potassium current plays...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Lagomorpha › Lapins › The transient outward potassium current plays...