Identification of key non-coding RNAs and transcription factors regulators and their potential drugs for steroid-induced femoral head necrosis.
Drug development
Functional modules
Precision treatment
Steroid-induced necrosis of femoral head
Journal
Genomics
ISSN: 1089-8646
Titre abrégé: Genomics
Pays: United States
ID NLM: 8800135
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
10
11
2019
revised:
20
09
2020
accepted:
22
12
2020
pubmed:
2
1
2021
medline:
23
2
2022
entrez:
1
1
2021
Statut:
ppublish
Résumé
Steroid-induced necrosis of femoral head (SINFH) is a femoral head necrotic disease caused by prolonged use of hormones. The detailed pathogenesis has not been fully demonstrated. In this study, we employed the bioinformatics approach to probe the roles of SINFH inhibitors. Core dysfunction modules related to SINFH was obtained. Meanwhile, GO and KEGG analysis of genes in dysfunction modules are carried out. Furthermore, the pivot prediction analysis of dysfunction modules related to ncRNA and transcription factor (TF) has been performed. The functions of the enriched modules were focused on multiple perspectives, including circulation, gland development, bone development and reconstruction, calcium production, and fatty acid metabolism regulation. The ncRNAs and TFs analysis showed that miR-322-5p, miR-124-3p, miR-125a-3p, and Ctnnb1 were important members of SINFH dysfunction. Drug targets suggested that Zinc and adenosine monophosphate may have an impact on SINFH dysfunction. SINFH was closely related to bone development and reconstruction.
Identifiants
pubmed: 33385494
pii: S0888-7543(20)32081-4
doi: 10.1016/j.ygeno.2020.12.034
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
RNA, Untranslated
0
Steroids
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
490-496Informations de copyright
Copyright © 2020. Published by Elsevier Inc.