Prenatal exposure to barium and the occurrence of neural tube defects in offspring.

Animals Barium / toxicity Bayes Theorem Case-Control Studies Female Mice Mice, Inbred ICR Neural Tube Defects / chemically induced Pregnancy Prenatal Exposure Delayed Effects
Alkaline earth metal Barium Bayesian kernel machine regression ICR mice Mixture effect Neural tube defects

Journal

The Science of the total environment
ISSN: 1879-1026
Titre abrégé: Sci Total Environ
Pays: Netherlands
ID NLM: 0330500

Informations de publication

Date de publication:
10 Apr 2021
Historique:
received: 27 09 2020
revised: 24 11 2020
accepted: 25 11 2020
pubmed: 2 1 2021
medline: 7 2 2021
entrez: 1 1 2021
Statut: ppublish

Résumé

Neural tube defects (NTDs) have a complex etiology. Few studies have assessed alkaline earth metals exposures and occurrence of NTDs. We examined the association between prenatal exposure to magnesium (Mg), calcium (Ca), strontium (Sr) and barium (Ba) and risk for NTDs in a case-control study, and assessed the teratogenic effects of Ba on mice. Placentas were collected from 408 women with NTD-affected pregnancies and 593 women who delivered healthy infants, and concentrations of these metals were determined as prenatal exposure markers. The single effect of individual exposure and joint effect of coexposure to these metals were evaluated with logistic regression and Bayesian kernel machine regression (BKMR), respectively. Barium chloride (BaCl

Identifiants

DOI: 10.1016/j.scitotenv.2020.144245 PMID: 33385660
pubmed: 33385660
pii: S0048-9697(20)37776-7
doi: 10.1016/j.scitotenv.2020.144245
pii:
doi:

Substances chimiques

Barium 24GP945V5T

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

144245

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Chengrong Wang (C)

Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China; Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China.

Xin Pi (X)

Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China; Department of Social Medicine and Health Education, School of Public Health, Peking University, Beijing, China.

Yongyan Chen (Y)

Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Di Wang (D)

Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Shengju Yin (S)

Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China; Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China.

Lei Jin (L)

Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Zhiwen Li (Z)

Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Aiguo Ren (A)

Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China; Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. Electronic address: renag@bjmu.edu.cn.

Linlin Wang (L)

Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. Electronic address: linlinwang@bjmu.edu.cn.

Chenghong Yin (C)

Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. Electronic address: yinchh@ccmu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Prenatal exposure to barium and the occurrence...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Baryum › Prenatal exposure to barium and the occurrence...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Théorème de Bayes › Prenatal exposure to barium and the occurrence...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Prenatal exposure to barium and the occurrence...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Prenatal exposure to barium and the occurrence...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée ICR › Prenatal exposure to barium and the occurrence...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations du système nerveux › Anomalies du tube neural › Prenatal exposure to barium and the occurrence...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Prenatal exposure to barium and the occurrence...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Lésions prénatales › Effets différés de l'exposition prénatale à des facteurs de risque › Prenatal exposure to barium and the occurrence...