Systemic and cerebral circulatory adjustment within the first 60 s after active standing: An integrative physiological view.
Aging
Anoxia reserve time
Cerebral autoregulation
Cerebral perfusion
Initial orthostatic hypotension
Systemic hemodynamics
Journal
Autonomic neuroscience : basic & clinical
ISSN: 1872-7484
Titre abrégé: Auton Neurosci
Pays: Netherlands
ID NLM: 100909359
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
30
06
2020
revised:
30
10
2020
accepted:
22
11
2020
pubmed:
2
1
2021
medline:
26
10
2021
entrez:
1
1
2021
Statut:
ppublish
Résumé
Transient cardiovascular and cerebrovascular responses within the first minute of active standing provide the means to assess autonomic, cardiovascular and cerebrovascular regulation using a real-world everyday stimulus. Traditionally, these responses have been used to detect autonomic dysfunction, and to identify the hemodynamic correlates of patient symptoms and attributable causes of (pre)syncope and falls. This review addresses the physiology of systemic and cerebrovascular adjustment within the first 60 s after active standing. Mechanical factors induced by standing up cause a temporal mismatch between cardiac output and vascular conductance which leads to an initial blood pressure drops with a nadir around 10 s. The arterial baroreflex counteracts these initial blood pressure drops, but needs 2-3 s to be initiated with a maximal effect occurring at 10 s after standing while, in parallel, cerebral autoregulation buffers these changes within 10 s to maintain adequate cerebral perfusion. Interestingly, both the magnitude of the initial drop and these compensatory mechanisms are thought to be quite well-preserved in healthy aging. It is hoped that the present review serves as a reference for future pathophysiological investigations and epidemiological studies. Further experimental research is needed to unravel the causal mechanisms underlying the emergence of symptoms and relationship with aging and adverse outcomes in variants of orthostatic hypotension.
Identifiants
pubmed: 33385733
pii: S1566-0702(20)30190-9
doi: 10.1016/j.autneu.2020.102756
pmc: PMC8103784
mid: NIHMS1697863
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102756Subventions
Organisme : NHLBI NIH HHS
ID : K23 HL135273
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier B.V.
Références
Clin Sci (Lond). 2007 Nov;113(10):401-7
pubmed: 17561808
BMC Public Health. 2015 Jan 17;15:9
pubmed: 25595219
BMJ. 1996 Aug 24;313(7055):436-7
pubmed: 8776299
Europace. 2004 Sep;6(5):457-62; discussion 463
pubmed: 15294273
Stroke. 2005 Dec;36(12):2595-600
pubmed: 16254228
Circulation. 2014 Nov 11;130(20):1780-9
pubmed: 25278101
Neurobiol Aging. 2011 Feb;32(2):344-53
pubmed: 19356825
N Engl J Med. 1994 Sep 29;331(13):821-7
pubmed: 8078528
Eur J Appl Physiol. 2019 May;119(5):1117-1125
pubmed: 30771059
J Gerontol A Biol Sci Med Sci. 2014 Jul;69(7):878-85
pubmed: 24214492
Aviat Space Environ Med. 2000 Nov;71(11):1167-8
pubmed: 11086679
Europace. 2007 Aug;9(8):563-7
pubmed: 17507364
Am J Physiol. 1982 Nov;243(5):H676-81
pubmed: 7137360
Clin Auton Res. 1995 Jun;5(3):171-7
pubmed: 7549420
Europace. 2021 May 21;23(5):797-805
pubmed: 33219671
J Neurosurg. 1986 Nov;65(5):636-41
pubmed: 3772451
J Am Geriatr Soc. 2017 Mar;65(3):474-482
pubmed: 28295143
J Am Geriatr Soc. 2011 Mar;59(3):383-9
pubmed: 21391928
Heart Rhythm. 2018 Jun;15(6):921-929
pubmed: 29246828
J Pediatr. 2011 Mar;158(3):499-504
pubmed: 20970148
Clin Sci (Lond). 1992 Aug;83(2):149-55
pubmed: 1327629
Clin Physiol. 1991 May;11(3):221-30
pubmed: 1893680
J Gerontol A Biol Sci Med Sci. 2014 Apr;69(4):471-8
pubmed: 23873962
J Appl Physiol (1985). 1990 Jan;68(1):147-53
pubmed: 2312453
J Appl Physiol (1985). 1994 Sep;77(3):1403-10
pubmed: 7836146
J Physiol. 2004 Oct 1;560(Pt 1):317-27
pubmed: 15284348
J Appl Physiol (1985). 2007 Aug;103(2):452-8
pubmed: 17463298
Clin Auton Res. 2004 Oct;14 Suppl 1:18-24
pubmed: 15480926
Circulation. 2002 Mar 19;105(11):1329-35
pubmed: 11901044
J Appl Physiol (1985). 2007 Aug;103(2):421-2
pubmed: 17540838
J Intern Med. 2017 Dec;282(6):468-483
pubmed: 28564488
Stroke. 2000 Jul;31(7):1608-14
pubmed: 10884461
Circ Res. 2016 Aug 19;119(5):582-3
pubmed: 27539969
Brain. 2009 Oct;132(Pt 10):2630-42
pubmed: 19587129
J Intern Med. 2013 Apr;273(4):345-58
pubmed: 23510365
Hypertension. 2020 Feb;75(2):524-531
pubmed: 31838912
Ann Intern Med. 2001 Oct 2;135(7):507-13
pubmed: 11578154
Stroke. 2000 Aug;31(8):1897-903
pubmed: 10926954
Age Ageing. 2021 May 5;50(3):854-860
pubmed: 32894746
Clin Sci (Lond). 1984 Sep;67(3):321-7
pubmed: 6467836
J Appl Physiol (1985). 2009 Aug;107(2):506-17
pubmed: 19541730
Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H2102-12
pubmed: 21856921
Eur Heart J. 2018 Jun 1;39(21):1883-1948
pubmed: 29562304
J Cereb Blood Flow Metab. 2008 Jun;28(6):1071-85
pubmed: 18349877
Stroke. 2001 Jul;32(7):1546-51
pubmed: 11441199
Clin Auton Res. 2011 Apr;21(2):69-72
pubmed: 21431947
Europace. 2018 Sep 1;20(9):1535-1542
pubmed: 29036615
Heart Rhythm. 2017 Aug;14(8):e155-e217
pubmed: 28286247
JAMA Intern Med. 2017 Sep 1;177(9):1316-1323
pubmed: 28738139
Hypertension. 2018 May;71(5):816-818
pubmed: 29632100
Am J Physiol Heart Circ Physiol. 2015 Feb 1;308(3):H153-6
pubmed: 25416194
Cardiovasc Res. 1990 Mar;24(3):214-21
pubmed: 2346955
Hypertension. 1992 Jun;19(6 Pt 1):508-19
pubmed: 1592445
J Physiol. 1999 Aug 15;519 Pt 1:1-10
pubmed: 10432334
J Clin Pharmacol. 1994 May;34(5):375-86
pubmed: 8089249
Clin Sci (Lond). 1990 Jul;79(1):73-9
pubmed: 2167794
Am J Cardiol. 2002 Mar 1;89(5):599-601
pubmed: 11867049
Circ Res. 2016 Aug 19;119(5):666-75
pubmed: 27330018
J Appl Physiol (1985). 2017 Apr 1;122(4):877-883
pubmed: 28082333
Clin Auton Res. 2020 Apr;30(2):105-106
pubmed: 31993807
Hypertension. 2018 May;71(5):946-954
pubmed: 29632103
J Appl Physiol (1985). 2003 Apr;94(4):1335-44
pubmed: 12626468
J Appl Physiol (1985). 2003 Mar;94(3):833-48
pubmed: 12571122
Stroke. 1989 Jan;20(1):45-52
pubmed: 2492126
Neurology. 2018 Aug 21;91(8):e759-e768
pubmed: 30045960
J Am Geriatr Soc. 2015 Sep;63(9):1868-73
pubmed: 26313614
Chronobiol Int. 2011 Mar;28(2):135-45
pubmed: 21231875
J Appl Physiol (1985). 1991 Feb;70(2):523-30
pubmed: 2022542
Clin Auton Res. 2020 Apr;30(2):129-137
pubmed: 31696333
Ultrasound Med Biol. 2009 Jan;35(1):21-9
pubmed: 18834658
J Physiol. 1996 Jul 15;494 ( Pt 2):601-11
pubmed: 8842017
Neurology. 2020 Oct 6;95(14):e1941-e1950
pubmed: 32732296
Am J Physiol Regul Integr Comp Physiol. 2013 Jan 15;304(2):R147-54
pubmed: 23174860
Clin Auton Res. 2019 Aug;29(4):427-441
pubmed: 31076939
Int J Cardiol. 2018 Nov 15;271:269-273
pubmed: 30223355
Clin Auton Res. 2016 Dec;26(6):441-449
pubmed: 27637670
Aviat Space Environ Med. 2007 Jul;78(7):653-8
pubmed: 17679561
J Am Heart Assoc. 2018 Oct 2;7(19):e008976
pubmed: 30371298
Neth J Med. 1985;28(10):383-92
pubmed: 4080043
Circulation. 1976 Apr;53(4):720-7
pubmed: 815061
Clin Sci (Lond). 2007 Feb;112(3):157-65
pubmed: 17199559
Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2152-65
pubmed: 16632542
Clin Physiol. 1996 Mar;16(2):157-70
pubmed: 8964133
Am J Cardiol. 1993 Nov 15;72(15):1152-5
pubmed: 8237805
J Physiol. 2004 Jan 15;554(Pt 2):579-90
pubmed: 14608002
J Gerontol A Biol Sci Med Sci. 2005 Nov;60(11):1484-7
pubmed: 16339339