Discovery of [1,2,4]triazolo[1,5-a]pyrimidines derivatives as potential anticancer agents.

Antineoplastic Agents / pharmacology Cell Proliferation / drug effects Drug Design Humans Pyrimidines / pharmacology Structure-Activity Relationship
Anticancer agents Antiproliferative activity [1,2,4]triazolo[1,5-a]pyrimidines

Journal

European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510

Informations de publication

Date de publication:
05 Feb 2021
Historique:
received: 04 11 2020
revised: 02 12 2020
accepted: 14 12 2020
pubmed: 2 1 2021
medline: 1 5 2021
entrez: 1 1 2021
Statut: ppublish

Résumé

In this work, we reported the discovery of compound 6i with potent antiproliferative activity against MGC-803. Among these compounds, the most potent compound 6i could effectively inhibit MGC-803 (IC

Identifiants

DOI: 10.1016/j.ejmech.2020.113108 PMID: 33385852
pubmed: 33385852
pii: S0223-5234(20)31080-1
doi: 10.1016/j.ejmech.2020.113108
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Pyrimidines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113108

Informations de copyright

Copyright © 2020 Elsevier Masson SAS. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Jin-Ling Huo (JL)

School of Pharmaceutical Sciences and Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, 450001, China.

Shuai Wang (S)

School of Pharmaceutical Sciences and Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, 450001, China; Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02129, USA.

Xiao-Han Yuan (XH)

School of Pharmaceutical Sciences and Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, 450001, China.

Bin Yu (B)

School of Pharmaceutical Sciences and Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, 450001, China. Electronic address: zzuyubin@hotmail.com.

Wen Zhao (W)

School of Pharmaceutical Sciences and Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, 450001, China. Electronic address: zhaowen@zzu.edu.cn.

Hong-Min Liu (HM)

School of Pharmaceutical Sciences and Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, 450001, China. Electronic address: liuhm@zzu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Discovery of [1,2,4]triazolo[1,5-a]pyrimidines...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Discovery of [1,2,4]triazolo[1,5-a]pyrimidines...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Discovery of [1,2,4]triazolo[1,5-a]pyrimidines...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Discovery of [1,2,4]triazolo[1,5-a]pyrimidines...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Discovery of [1,2,4]triazolo[1,5-a]pyrimidines...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Discovery of [1,2,4]triazolo[1,5-a]pyrimidines...