Understanding of cytokines and targeted therapy in macrophage activation syndrome.

Adult Arthritis, Juvenile Cyclosporine Cytokines Humans Macrophage Activation Syndrome / drug therapy Still's Disease, Adult-Onset

Journal

Seminars in arthritis and rheumatism
ISSN: 1532-866X
Titre abrégé: Semin Arthritis Rheum
Pays: United States
ID NLM: 1306053

Informations de publication

Date de publication:
02 2021
Historique:
received: 14 10 2020
revised: 01 12 2020
accepted: 21 12 2020
pubmed: 2 1 2021
medline: 30 9 2021
entrez: 1 1 2021
Statut: ppublish

Résumé

Macrophage activation syndrome (MAS) is a potentially life-threatening complication of systemic autoinflammatory/autoimmune diseases, generally systemic juvenile idiopathic arthritis and adult-onset Still's disease. It is characterized by an excessive proliferation of macrophages and T lymphocytes. Recent research revealed that cytokine storm with elevated pro-inflammatory cytokines, including IFN-γ, IL-18, and IL-6, may be central to the pathogenesis of MAS. Though the mainstream of MAS treatment remains corticosteroids and cyclosporine, targeted therapies with anti-cytokine biologics are reported to be promising for controlling systemic inflammation in MAS.

Identifiants

DOI: 10.1016/j.semarthrit.2020.12.007 PMID: 33385860
pubmed: 33385860
pii: S0049-0172(20)30315-2
doi: 10.1016/j.semarthrit.2020.12.007
pii:
doi:

Substances chimiques

Cytokines 0
Cyclosporine 83HN0GTJ6D

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

198-210

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no conflict of interest.

Auteurs

Shunli Tang (S)

Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Sheng Li (S)

Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Siting Zheng (S)

Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Yuwei Ding (Y)

Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Dingxian Zhu (D)

Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Chuanyin Sun (C)

Department of Rheumatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Yongxian Hu (Y)

Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Jianjun Qiao (J)

Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: qiaojianjun@zju.edu.cn.

Hong Fang (H)

Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: fanghongzy@zju.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Understanding of cytokines and targeted...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Arthrite juvénile › Understanding of cytokines and targeted...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Cyclosporines › Ciclosporine › Understanding of cytokines and targeted...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Understanding of cytokines and targeted...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Understanding of cytokines and targeted...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Syndrome d'activation macrophagique › Understanding of cytokines and targeted...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Polyarthrite rhumatoïde › Maladie de Still débutant à l'âge adulte › Understanding of cytokines and targeted...