Tissue engineered platforms for studying primary and metastatic neoplasm behavior in bone.
3D tumor model
Biomaterials
Cancer therapy
Mechanical properties
Tumor microenvironment
Journal
Journal of biomechanics
ISSN: 1873-2380
Titre abrégé: J Biomech
Pays: United States
ID NLM: 0157375
Informations de publication
Date de publication:
22 01 2021
22 01 2021
Historique:
received:
14
08
2020
revised:
02
12
2020
accepted:
11
12
2020
pubmed:
2
1
2021
medline:
28
5
2021
entrez:
1
1
2021
Statut:
ppublish
Résumé
Cancer is the second leading cause of death in the United States, claiming more than 560,000 lives each year. Osteosarcoma (OS) is the most common primary malignant tumor of bone in children and young adults, while bone is a common site of metastasis for tumors initiating from other tissues. The heterogeneity, continual evolution, and complexity of this disease at different stages of tumor progression drives a critical need for physiologically relevant models that capture the dynamic cancer microenvironment and advance chemotherapy techniques. Monolayer cultures have been favored for cell-based research for decades due to their simplicity and scalability. However, the nature of these models makes it impossible to fully describe the biomechanical and biochemical cues present in 3-dimensional (3D) microenvironments, such as ECM stiffness, degradability, surface topography, and adhesivity. Biomaterials have emerged as valuable tools to model the behavior of various cancers by creating highly tunable 3D systems for studying neoplasm behavior, screening chemotherapeutic drugs, and developing novel treatment delivery techniques. This review highlights the recent application of biomaterials toward the development of tumor models, details methods for their tunability, and discusses the clinical and therapeutic applications of these systems.
Identifiants
pubmed: 33385867
pii: S0021-9290(20)30613-8
doi: 10.1016/j.jbiomech.2020.110189
pmc: PMC7855491
mid: NIHMS1658592
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
110189Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE025475
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE025899
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM136559
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL086350
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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