Sub-multiplicative interaction between polygenic risk score and household coal use in relation to lung adenocarcinoma among never-smoking women in Asia.

Adenocarcinoma of Lung / epidemiology Air Pollution, Indoor Asia Case-Control Studies China / epidemiology Coal Female Genome-Wide Association Study Humans Lung Neoplasms / epidemiology Risk Factors Smoking Taiwan
Gene-environment interaction Household coal use Lung adenocarcinoma Never-smoking women in Asia Polygenic risk score

Journal

Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270

Informations de publication

Date de publication:
02 2021
Historique:
received: 25 02 2020
revised: 07 07 2020
accepted: 10 07 2020
pubmed: 2 1 2021
medline: 24 4 2021
entrez: 1 1 2021
Statut: ppublish

Résumé

We previously identified 10 lung adenocarcinoma susceptibility loci in a genome-wide association study (GWAS) conducted in the Female Lung Cancer Consortium in Asia (FLCCA), the largest genomic study of lung cancer among never-smoking women to date. Furthermore, household coal use for cooking and heating has been linked to lung cancer in Asia, especially in Xuanwei, China. We investigated the potential interaction between genetic susceptibility and coal use in FLCCA. We analyzed GWAS-data from Taiwan, Shanghai, and Shenyang (1472 cases; 1497 controls), as well as a separate study conducted in Xuanwei (152 cases; 522 controls) for additional analyses. We summarized genetic susceptibility using a polygenic risk score (PRS), which was the weighted sum of the risk-alleles from the 10 previously identified loci. We estimated associations between a PRS, coal use (ever/never), and lung adenocarcinoma with multivariable logistic regression models, and evaluated potential gene-environment interactions using likelihood ratio tests. There was a strong association between continuous PRS and lung adenocarcinoma among never coal users (Odds Ratio (OR) = 1.69 (95% Confidence Interval (CI) = 1.53, 1.87), p=1 × 10

Identifiants

DOI: 10.1016/j.envint.2020.105975 PMID: 33385923 PMC: PMC8378844
pubmed: 33385923
pii: S0160-4120(20)31930-9
doi: 10.1016/j.envint.2020.105975
pmc: PMC8378844
mid: NIHMS1730622
pii:
doi:

Substances chimiques

Coal 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

105975

Subventions

Organisme : NCI NIH HHS
ID : U19 CA148127
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CN25514
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG010480
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA070867
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CN25524
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CN25513
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA121210
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CN25518
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CN25516
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CN25476
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CN25404
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CN045165
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009314
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CN75022
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CN25512
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CN25511
Pays : United States
Organisme : CCR NIH HHS
ID : N01RC37004
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CN25522
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CN25515
Pays : United States

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

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Auteurs

Batel Blechter (B)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: bblechter@jhu.edu.

Jason Y Y Wong (JYY)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Chao Agnes Hsiung (C)

Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.

H Dean Hosgood (HD)

Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.

Zhihua Yin (Z)

Department of Epidemiology, School of Public Health, China Medical University, Shenyang, People's Republic of China.

Xiao-Ou Shu (XO)

Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.

Han Zhang (H)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Jianxin Shi (J)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Lei Song (L)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Minsun Song (M)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA; Department of Statistics, Sookmyung Women's University, Seoul, Republic of Korea.

Wei Zheng (W)

Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.

Zhaoming Wang (Z)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Neil Caporaso (N)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Laurie Burdette (L)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, Frederick National Laboratory for Cancer Research, Frederick, MD, USA; Leidos Biomedical Research, Inc., Frederick, MD, USA.

Meredith Yeager (M)

Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

Sonja I Berndt (SI)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Maria Teresa Landi (M)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Chien-Jen Chen (CJ)

Genomic Research Center, Academia Sinica, Taipei, Taiwan.

Gee-Chen Chang (GC)

Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

Chin-Fu Hsiao (CF)

Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.

Ying-Huang Tsai (YH)

Division of Pulmonary and Critical Care Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.

Kuan-Yu Chen (KY)

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Ming-Shyan Huang (MS)

Department of Internal Medicine, E-Da Cancer Hospital, School of Medicine, I-Shou University, Kaohsiung, Taiwan.

Wu-Chou Su (WC)

Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Yuh-Min Chen (YM)

Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.

Li-Hsin Chien (LH)

Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.

Chung-Hsing Chen (CH)

National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.

Tsung-Ying Yang (TY)

Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

Chih-Liang Wang (CL)

Department of Pulmonary and Critical Care, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Jen-Yu Hung (JY)

Department of Internal Medicine, Kaohsiung Medical University Hospital, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Chien-Chung Lin (CC)

Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Reury-Perng Perng (RP)

Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Chih-Yi Chen (CY)

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Division of Thoracic Surgery, Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan.

Kun-Chieh Chen (KC)

Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

Yao-Jen Li (YJ)

Genomic Research Center, Academia Sinica, Taipei, Taiwan.

Chong-Jen Yu (CJ)

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Yi-Song Chen (YS)

Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.

Ying-Hsiang Chen (YH)

Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.

Fang-Yu Tsai (FY)

National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.

Wei Jie Seow (W)

Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Bryan A Bassig (BA)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Wei Hu (W)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Bu-Tian Ji (BT)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Wei Wu (W)

Department of Epidemiology, School of Public Health, China Medical University, Shenyang, People's Republic of China.

Peng Guan (P)

Department of Epidemiology, School of Public Health, China Medical University, Shenyang, People's Republic of China.

Qincheng He (Q)

Department of Epidemiology, School of Public Health, China Medical University, Shenyang, People's Republic of China.

Yu-Tang Gao (YT)

Department of Epidemiology, Shanghai Cancer Institute, Shanghai, People's Republic of China.

Qiuyin Cai (Q)

Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.

Wong-Ho Chow (WH)

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Yong-Bing Xiang (YB)

Department of Epidemiology, Shanghai Cancer Institute, Shanghai, People's Republic of China.

Dongxin Lin (D)

Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Chen Wu (C)

Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Yi-Long Wu (YL)

Guangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.

Min-Ho Shin (MH)

Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.

Yun-Chul Hong (YC)

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

Keitaro Matsuo (K)

Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.

Kexin Chen (K)

Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China.

Maria Pik Wong (M)

Department of Pathology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong.

Daru Lu (D)

Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, People's Republic of China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.

Li Jin (L)

Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, People's Republic of China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.

Jiu-Cun Wang (JC)

Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, People's Republic of China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.

Adeline Seow (A)

Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.

Tangchun Wu (T)

Department of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Hongbing Shen (H)

Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.

Joseph F Fraumeni (JF)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Pan-Chyr Yang (PC)

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

I-Shou Chang (IS)

National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.

Baosen Zhou (B)

Department of Epidemiology, School of Public Health, China Medical University, Shenyang, People's Republic of China.

Stephen J Chanock (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Nathaniel Rothman (N)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Nilanjan Chatterjee (N)

Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Qing Lan (Q)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs du thorax › Adénocarcinome pulmonaire › Sub-multiplicative interaction between...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Pollution de l'air › Pollution de l'air intérieur › Sub-multiplicative interaction between...
questionsmedicales.fr › Régions géographiques › Asie › Sub-multiplicative interaction between...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Sub-multiplicative interaction between...
questionsmedicales.fr › Régions géographiques › Asie › Extrême-Orient › Chine › Sub-multiplicative interaction between...
questionsmedicales.fr › Environnement et santé publique › Environnement › Ressources de production d'énergie › Combustibles fossiles › Charbon › Sub-multiplicative interaction between...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Sub-multiplicative interaction between...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sub-multiplicative interaction between...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Sub-multiplicative interaction between...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Sub-multiplicative interaction between...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Fumer › Sub-multiplicative interaction between...
questionsmedicales.fr › Régions géographiques › Iles › Taïwan › Sub-multiplicative interaction between...