Preferential accumulation of the active S-(+) isomer in murine retina highlights novel mechanisms of vigabatrin-associated retinal toxicity.

4-Aminobutyrate Transaminase Animals Anticonvulsants / toxicity Male Mice Mice, Inbred C57BL Retina Vigabatrin / toxicity
2-aminoadipic acid GABA Isomers Retina Vigabatrin

Journal

Epilepsy research
ISSN: 1872-6844
Titre abrégé: Epilepsy Res
Pays: Netherlands
ID NLM: 8703089

Informations de publication

Date de publication:
02 2021
Historique:
received: 29 09 2020
revised: 27 11 2020
accepted: 15 12 2020
pubmed: 2 1 2021
medline: 10 2 2022
entrez: 1 1 2021
Statut: ppublish

Résumé

((S)-(+)/(R)-(-)) vigabatrin (Sabril

Identifiants

DOI: 10.1016/j.eplepsyres.2020.106536 PMID: 33385945 PMC: PMC7897276
pubmed: 33385945
pii: S0920-1211(20)30587-8
doi: 10.1016/j.eplepsyres.2020.106536
pmc: PMC7897276
mid: NIHMS1657513
pii:
doi:

Substances chimiques

Anticonvulsants 0
4-Aminobutyrate Transaminase EC 2.6.1.19
Vigabatrin GR120KRT6K

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

106536

Subventions

Organisme : NEI NIH HHS
ID : R01 EY027476
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Références

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Auteurs

Dana C Walters (DC)

Department of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA.

Erwin E W Jansen (EEW)

Department of Clinical Chemistry, Metabolic Unit, VU University Medical Center & Amsterdam Neuroscience, Amsterdam, the Netherlands.

Gajja S Salomons (GS)

Department of Clinical Chemistry, Metabolic Unit, VU University Medical Center & Amsterdam Neuroscience, Amsterdam, the Netherlands.

Erland Arning (E)

Baylor Scott & White Research Institute, Institute of Metabolic Disease, Dallas, TX, USA.

Paula Ashcraft (P)

Baylor Scott & White Research Institute, Institute of Metabolic Disease, Dallas, TX, USA.

Teodoro Bottiglieri (T)

Baylor Scott & White Research Institute, Institute of Metabolic Disease, Dallas, TX, USA.

Jean-Baptiste Roullet (JB)

Department of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA.

K Michael Gibson (KM)

Department of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA. Electronic address: mike.gibson@wsu.edu.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Nitrogenous group transferases › Transaminases › 4-Aminobutyrate transaminase › Preferential accumulation of the active S-(+)...
questionsmedicales.fr › Eucaryotes › Animaux › Preferential accumulation of the active S-(+)...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Anticonvulsivants › Preferential accumulation of the active S-(+)...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Preferential accumulation of the active S-(+)...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Preferential accumulation of the active S-(+)...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Preferential accumulation of the active S-(+)...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Vigabatrine › Preferential accumulation of the active S-(+)...