2-[
18F-FDG
CLL
PET/CT
Richter transformation
Journal
Clinical lymphoma, myeloma & leukemia
ISSN: 2152-2669
Titre abrégé: Clin Lymphoma Myeloma Leuk
Pays: United States
ID NLM: 101525386
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
19
11
2020
revised:
02
12
2020
accepted:
03
12
2020
pubmed:
3
1
2021
medline:
6
1
2022
entrez:
2
1
2021
Statut:
ppublish
Résumé
Chronic lymphocytic leukemia (CLL) is an indolent, low-grade B-cell lymphoproliferative disorder, which may evolve into aggressive lymphoma, a phenomenon called Richter syndrome (RS). Our aim was to study the accuracy of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (2-[18F]-FDG PET/CT) and its semiquantitative parameters for the detection of RS and the impact on overall survival (OS). Eighty patients with histologically proven CLL were retrospectively included. PET/CT images were qualitatively and semiquantitatively examined by estimating the maximum standardized uptake value body weight (SUVbw), lean body mass (SUVlbm), body surface area (SUVbsa), lesion-to-blood-pool SUV ratio (L-BP SUV R), lesion-to-liver SUV ratio (L-L SUV R), total lesion glycolysis (TLG), and metabolic tumor volume (MTV) and comparing them with the main clinical-histologic variables. OS curves were plotted according to the Kaplan-Meier method. Seventy-eight patients had positive 2-[ Semiquantitative PET/CT parameters that are SUV-related may be useful in discriminating patients with a high risk of developing RS and also for predicting OS.
Identifiants
pubmed: 33386279
pii: S2152-2650(20)30670-4
doi: 10.1016/j.clml.2020.12.003
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e277-e283Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.