Changes in olfactory function and olfactory bulb after treatment for acromegaly.
Acromegaly
Olfaction
Olfactory bulb
Olfactory dysfunction
Journal
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
ISSN: 1434-4726
Titre abrégé: Eur Arch Otorhinolaryngol
Pays: Germany
ID NLM: 9002937
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
08
10
2020
accepted:
20
11
2020
pubmed:
3
1
2021
medline:
2
6
2021
entrez:
2
1
2021
Statut:
ppublish
Résumé
This study aimed to investigate the olfactory functions of the acromegaly patients and to discuss the possible causes of olfactory dysfunction in acromegaly patients. A case-control study was carried out in a tertiary referral center. 52 patients with acromegaly (Acromegaly group) and 52 healthy individuals (Control group) were included in the study. All acromegaly patients included in the study were in the late postoperative period. The Connecticut Chemosensory Clinical Research Center (CCCRC) test was carried out and olfactory bulb (OB) volumes were measured in both of the groups. There was a significant difference between the mean CCCRC total scores of the acromegaly and control groups (p = .000). The mean of right and left OB volumes in the acromegaly group was significantly higher than the control group (p = .004) CONCLUSION: In this study, we found that acromegaly patients are likely to experience olfactory dysfunction. It is important to examine these patients' olfactory functions at the time of diagnosis and clinic follow-up. NCT04138537.
Identifiants
pubmed: 33386970
doi: 10.1007/s00405-020-06515-5
pii: 10.1007/s00405-020-06515-5
doi:
Banques de données
ClinicalTrials.gov
['NCT04138537']
Types de publication
Clinical Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2357-2362Références
Taghvaei M, Sadrehosseini SM, Ardakani JB, Nakhjavani M, Zeinalizadeh M (2018) Endoscopic endonasal approach to the growth hormone-secreting pituitary adenomas: endocrinologic outcome in 68 patients. World Neurosurg 117:e259–e268. https://doi.org/10.1016/j.wneu.2018.06.009
doi: 10.1016/j.wneu.2018.06.009
pubmed: 29902603
Galm BP, Buckless C, Swearingen B, Torriani M, Klibanski A, Bredella MA, Tritos NA (2020) MRI texture analysis in acromegaly and its role in predicting response to somatostatin receptor ligands. Pituitary. https://doi.org/10.1007/s11102-019-01023-0
doi: 10.1007/s11102-019-01023-0
pubmed: 31897778
Wu JC, Huang WC, Chang HK, Ko CC, Lirng JF, Chen YC (2019) Natural history of acromegaly: Incidences, re-operations, cancers, and mortality rates in a national cohort. Neuroendocrinology. https://doi.org/10.1159/000505332
doi: 10.1159/000505332
pubmed: 31822015
Coopmans EC, van Meyel SWF, van der Lely AJ, Neggers S (2019) The position of combined medical treatment in acromegaly. Arch Endocrinol Metab 63(6):646–652. https://doi.org/10.20945/2359-3997000000195
doi: 10.20945/2359-3997000000195
pubmed: 31939490
Veyseller B, Ozucer B, Karaaltin AB, Yildirim Y, Degirmenci N, Aksoy F, Ozturan O (2014) Connecticut (CCCRC) olfactory test: normative values in 426 healthy volunteers. Indian J Otolaryngol Head Neck Surg 66(1):31–34. https://doi.org/10.1007/s12070-013-0632-z
doi: 10.1007/s12070-013-0632-z
pubmed: 24605298
Cain WS, Goodspeed RB, Gent JF, Leonard G (1988) Evaluation of olfactory dysfunction in the connecticut chemosensory clinical research center. The Laryngoscope 98(1):83–88. https://doi.org/10.1288/00005537-198801000-00017
doi: 10.1288/00005537-198801000-00017
pubmed: 3336267
Kilicarslan R, Ilhan MM, Alkan A, Aralasmak A, Akkoyunlu ME, Kart L, Tasan E (2014) Microstructural brain changes in acromegaly: quantitative analysis by diffusion tensor imaging. Br J Radiol 87(1038):20130801. https://doi.org/10.1259/bjr.20130801
doi: 10.1259/bjr.20130801
pubmed: 24734977
pmcid: 4075559
Aberg ND, Brywe KG, Isgaard J (2006) Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain. Sci World J 6:53–80. https://doi.org/10.1100/tsw.2006.22
doi: 10.1100/tsw.2006.22
Carleton A, Petreanu LT, Lansford R, Alvarez-Buylla A, Lledo PM (2003) Becoming a new neuron in the adult olfactory bulb. Nat Neurosci 6(5):507–518. https://doi.org/10.1038/nn1048
doi: 10.1038/nn1048
pubmed: 12704391
Vicario-Abejón C, Yusta-Boyo MJ, Fernández-Moreno C, de Pablo F (2003) Locally born olfactory bulb stem cells proliferate in response to insulin-related factors and require endogenous insulin-like growth factor-I for differentiation into neurons and glia. J Neurosci Off J Soc Neurosci 23(3):895–906. https://doi.org/10.1523/jneurosci.23-03-00895.2003
doi: 10.1523/jneurosci.23-03-00895.2003
Yan H, Bunge MB, Wood PM, Plant GW (2001) Mitogenic response of adult rat olfactory ensheathing glia to four growth factors. Glia 33(4):334–342. https://doi.org/10.1002/1098-1136(20010315)33:4%3c334::aid-glia1032%3e3.0.co;2-i
doi: 10.1002/1098-1136(20010315)33:4<334::aid-glia1032>3.0.co;2-i
pubmed: 11246232
Lledo PM, Gheusi G (2003) Olfactory processing in a changing brain. NeuroReport 14(13):1655–1663. https://doi.org/10.1097/00001756-200309150-00001
doi: 10.1097/00001756-200309150-00001
pubmed: 14512833
Patel RM, Pinto JM (2014) Olfaction: anatomy, physiology, and disease. Clin Anat 27(1):54–60. https://doi.org/10.1002/ca.22338
doi: 10.1002/ca.22338
pubmed: 24272785
Kern RC (2000) Chronic sinusitis and anosmia: pathologic changes in the olfactory mucosa. Laryngoscope 110(7):1071–1077. https://doi.org/10.1097/00005537-200007000-00001
doi: 10.1097/00005537-200007000-00001
pubmed: 10892672
Degirmenci N, Veyseller B, Hanagasi H, Bilgic B, Gurbuz D, Toprak A, Ozturan O (2019) Olfactory function and olfactory bulb volume in Wilson’s disease. Eur Arch Otorhinolaryngol 276(1):139–142. https://doi.org/10.1007/s00405-018-5216-9
doi: 10.1007/s00405-018-5216-9
pubmed: 30467777
Skinner DW, Richards SH (1988) Acromegaly—the mucosal changes within the nose and paranasal sinuses. J Laryngol Otol 102(12):1107–1110. https://doi.org/10.1017/s0022215100107455
doi: 10.1017/s0022215100107455
pubmed: 3225521
Rotenberg BW, Saunders S, Duggal N (2011) Olfactory outcomes after endoscopic transsphenoidal pituitary surgery. Laryngoscope 121(8):1611–1613. https://doi.org/10.1002/lary.21890
doi: 10.1002/lary.21890
pubmed: 21647916
de Almeida JR, Snyderman CH, Gardner PA, Carrau RL, Vescan AD (2011) Nasal morbidity following endoscopic skull base surgery: a prospective cohort study. Head Neck 33(4):547–551. https://doi.org/10.1002/hed.21483
doi: 10.1002/hed.21483
pubmed: 20824807
Zhu J, Feng K, Tang C, Yang J, Cai X, Zhong C, Ma C (2020) Olfactory outcomes after endonasal skull base surgery: a systematic review. Neurosurg Rev. https://doi.org/10.1007/s10143-020-01385-1
doi: 10.1007/s10143-020-01385-1
pubmed: 32914235
pmcid: 7851104
Alobid I, Ensenat J, Marino-Sanchez F, de Notaris M, Centellas S, Mullol J, Bernal-Sprekelsen M (2013) Impairment of olfaction and mucociliary clearance after expanded endonasal approach using vascularized septal flap reconstruction for skull base tumors. Neurosurgery 72(4):540–546. https://doi.org/10.1227/NEU.0b013e318282a535
doi: 10.1227/NEU.0b013e318282a535
pubmed: 23246823
Tan LK, Jones RA (1995) Nasal complications of the direct transnasal approach to the pituitary fossa. Br J Neurosurg 9(6):739–742. https://doi.org/10.1080/02688699550040693
doi: 10.1080/02688699550040693
pubmed: 8719828
Hong SD, Nam DH, Park J, Kim HY, Chung SK, Dhong HJ (2014) Olfactory outcomes after endoscopic pituitary surgery with nasoseptal “rescue” flaps: electrocautery versus cold knife. Am J Rhinol Allergy 28(6):517–519. https://doi.org/10.2500/ajra.2014.28.4109
doi: 10.2500/ajra.2014.28.4109
pubmed: 25514489
Kim SW, Park KB, Khalmuratova R, Lee HK, Jeon SY, Kim DW (2013) Clinical and histologic studies of olfactory outcomes after nasoseptal flap harvesting. Laryngoscope 123(7):1602–1606. https://doi.org/10.1002/lary.24107
doi: 10.1002/lary.24107
pubmed: 23798331
Lee JJ, Thompson ZS, Piccirillo JF, Klatt-Cromwell CN, Orlowski HLP, Kallogjeri D, Pipkorn P, Schneider JS (2020) Risk factors for patient-reported olfactory dysfunction after endoscopic transsphenoidal hypophysectomy. JAMA Otolaryngol Head Neck Surg 146(7):621–629. https://doi.org/10.1001/jamaoto.2020.0673
doi: 10.1001/jamaoto.2020.0673
pubmed: 32379292
Koskinen K, Reichert JL, Hoier S, Schachenreiter J, Duller S, Moissl-Eichinger C, Schopf V (2018) The nasal microbiome mirrors and potentially shapes olfactory function. Sci Rep 8(1):1296. https://doi.org/10.1038/s41598-018-19438-3
doi: 10.1038/s41598-018-19438-3
pubmed: 29358754
pmcid: 5778015