Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain.
Adult
Antibodies, Neutralizing
/ biosynthesis
Antibodies, Viral
/ blood
COVID-19
/ immunology
Cross Infection
/ immunology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin G
/ biosynthesis
Infectious Disease Transmission, Patient-to-Professional
Male
Middle Aged
Nasopharynx
/ virology
SARS-CoV-2
/ classification
COVID-19
IgG
Neutralizing antibody
Receptor-binding domain
SARS-CoV-2
Journal
Infection
ISSN: 1439-0973
Titre abrégé: Infection
Pays: Germany
ID NLM: 0365307
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
12
09
2020
accepted:
10
11
2020
pubmed:
3
1
2021
medline:
19
8
2021
entrez:
2
1
2021
Statut:
ppublish
Résumé
We report here the case of two coworkers infected by the same SARS-CoV-2 strain, presenting two different immunological outcomes. One patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low and rapidly decreasing titer of neutralizing antibodies. The other patient had a similar strong IgG anti-receptor-binding domain immune response but high neutralizing antibody titers. Thus, host individual factors may be the main drivers of the immune response varying with age and clinical severity.
Sections du résumé
BACKGROUND
BACKGROUND
We report here the case of two coworkers infected by the same SARS-CoV-2 strain, presenting two different immunological outcomes.
CASE
METHODS
One patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low and rapidly decreasing titer of neutralizing antibodies. The other patient had a similar strong IgG anti-receptor-binding domain immune response but high neutralizing antibody titers.
DISCUSSION AND CONCLUSION
CONCLUSIONS
Thus, host individual factors may be the main drivers of the immune response varying with age and clinical severity.
Identifiants
pubmed: 33387262
doi: 10.1007/s15010-020-01556-8
pii: 10.1007/s15010-020-01556-8
pmc: PMC7776280
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Immunoglobulin G
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
781-783Subventions
Organisme : Délégation Générale pour l'Armement
ID : Biomedef COVID 5
Informations de copyright
© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.
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