An Eight Amino Acid Segment Controls Oligomerization and Preferred Conformation of the two Non-visual Arrestins.
IP(6)
isoforms
oligomer
signaling protein
structure
Journal
Journal of molecular biology
ISSN: 1089-8638
Titre abrégé: J Mol Biol
Pays: Netherlands
ID NLM: 2985088R
Informations de publication
Date de publication:
19 02 2021
19 02 2021
Historique:
received:
30
07
2020
revised:
14
12
2020
accepted:
22
12
2020
pubmed:
3
1
2021
medline:
24
4
2021
entrez:
2
1
2021
Statut:
ppublish
Résumé
G protein coupled receptors signal through G proteins or arrestins. A long-standing mystery in the field is why vertebrates have two non-visual arrestins, arrestin-2 and arrestin-3. These isoforms are ~75% identical and 85% similar; each binds numerous receptors, and appear to have many redundant functions, as demonstrated by studies of knockout mice. We previously showed that arrestin-3 can be activated by inositol-hexakisphosphate (IP
Identifiants
pubmed: 33387531
pii: S0022-2836(20)30715-4
doi: 10.1016/j.jmb.2020.166790
pmc: PMC7870585
mid: NIHMS1661614
pii:
doi:
Substances chimiques
Amino Acids
0
Arrestins
0
Protein Isoforms
0
Solutions
0
Phytic Acid
7IGF0S7R8I
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
166790Subventions
Organisme : NIDA NIH HHS
ID : R21 DA043680
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM120569
Pays : United States
Organisme : NIH HHS
ID : S10 OD011937
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103622
Pays : United States
Organisme : NIH HHS
ID : S10 OD018090
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR022422
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB001980
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY011500
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM122491
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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