Ethnicity as modifier of risk for Vitamin D receptors polymorphisms: Comprehensive meta-analysis of all cancer sites.
Cancer
Ethnicity
Meta-analysis
Polymorphisms
Review
VDR
Vitamin D
Journal
Critical reviews in oncology/hematology
ISSN: 1879-0461
Titre abrégé: Crit Rev Oncol Hematol
Pays: Netherlands
ID NLM: 8916049
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
07
04
2020
revised:
16
11
2020
accepted:
20
12
2020
pubmed:
3
1
2021
medline:
16
2
2021
entrez:
2
1
2021
Statut:
ppublish
Résumé
Vitamin D receptors polymorphisms are found to be associated with several cancers. Since their prevalence vary across ethnicities and ethnicity itself seems to influence the cancer risk, a comprehensive meta-analysis was performed to investigate the role of VDR Fok1, Bsm1, Taq1, Apa1, Cdx2 and cancer risk at specific organ sites. Odds ratios, calculated with random-effects models, summarized one-hundred-ninety-two independent studies for twenty-two cancer sites. Evidence was provided that Fok1, Bsm1, Cdx2, Apa1 and Taq1 are linked to cancer susceptibility for colorectal, lung, ovarian, skin, multiple myeloma and brain cancer. Stratifying by ethnicity, some differences were found, partially explained by minor allele frequency (MAF), for colorectal cancer, ovarian and prostate cancer in Caucasian and prostate cancer in Asian populations. In summary, ethnicity may be a modifier of cancer risk, in particular for hormone dependent cancers and it should be considered evaluating the effect of VDR on cancer risk.
Identifiants
pubmed: 33387627
pii: S1040-8428(20)30338-3
doi: 10.1016/j.critrevonc.2020.103202
pii:
doi:
Substances chimiques
Receptors, Calcitriol
0
Vitamin D
1406-16-2
Types de publication
Journal Article
Meta-Analysis
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
103202Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.