Type 1 helper T cells generate CXCL9/10-producing T-bet

Adult Aged Aged, 80 and over Arthritis, Rheumatoid / immunology B-Lymphocyte Subsets / immunology Chemokine CXCL10 / immunology Chemokine CXCL9 / immunology Female Gene Expression Humans Interferon-gamma / metabolism Lymphocyte Activation Male Middle Aged Th1 Cells / immunology
B cells CXCL10 CXCL9 Rheumatoid arthritis T-bet

Journal

Cellular immunology
ISSN: 1090-2163
Titre abrégé: Cell Immunol
Pays: Netherlands
ID NLM: 1246405

Informations de publication

Date de publication:
02 2021
Historique:
received: 16 08 2020
revised: 19 11 2020
accepted: 14 12 2020
pubmed: 3 1 2021
medline: 29 6 2021
entrez: 2 1 2021
Statut: ppublish

Résumé

Efficacy of B-cell depletion therapy highlights the antibody-independent effector functions of B cells in rheumatoid arthritis (RA). Given type 1 helper T (Th1) cells abundant in synovial fluid (SF) of RA, we have determined whether Th1 cells could generate novel effector B cells. Microarray and qPCR analysis identified CXCL9/10 transcripts as highly expressed genes upon BCR/CD40/IFN-γ stimulation. Activated Th1 cells promoted the generation of CXCL9/10-producing T-bet

Identifiants

DOI: 10.1016/j.cellimm.2020.104263 PMID: 33387686
pubmed: 33387686
pii: S0008-8749(20)30423-8
doi: 10.1016/j.cellimm.2020.104263
pii:
doi:

Substances chimiques

CXCL10 protein, human 0
CXCL9 protein, human 0
Chemokine CXCL10 0
Chemokine CXCL9 0
Interferon-gamma 82115-62-6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

104263

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Tsuyoshi Nakayama (T)

Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Motoki Yoshimura (M)

Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Kazuhiko Higashioka (K)

Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Kohta Miyawaki (K)

Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Yuri Ota (Y)

Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Masahiro Ayano (M)

Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Yasutaka Kimoto (Y)

Department of Internal Medicine and Clinical Immunology, Kyushu University Beppu Hospital, Beppu, Japan.

Hiroki Mitoma (H)

Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Nobuyuki Ono (N)

Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Yojiro Arinobu (Y)

Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Makoto Kikukawa (M)

Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Hisakata Yamada (H)

Department of Arthritis and Immunology, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Koichi Akashi (K)

Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Takahiko Horiuchi (T)

Department of Internal Medicine and Clinical Immunology, Kyushu University Beppu Hospital, Beppu, Japan.

Hiroaki Niiro (H)

Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. Electronic address: hniiro@med.kyushu-u.ac.jp.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Type 1 helper T cells generate CXCL9/10-producing T-bet
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Type 1 helper T cells generate CXCL9/10-producing T-bet
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Type 1 helper T cells generate CXCL9/10-producing T-bet
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Polyarthrite rhumatoïde › Type 1 helper T cells generate CXCL9/10-producing T-bet
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Sous-populations de lymphocytes B › Type 1 helper T cells generate CXCL9/10-producing T-bet
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › Chimiokines CXC › Chimiokine CXCL10 › Type 1 helper T cells generate CXCL9/10-producing T-bet
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › Chimiokines CXC › Chimiokine CXCL9 › Type 1 helper T cells generate CXCL9/10-producing T-bet
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Type 1 helper T cells generate CXCL9/10-producing T-bet
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Type 1 helper T cells generate CXCL9/10-producing T-bet
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › Type 1 helper T cells generate CXCL9/10-producing T-bet
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Type 1 helper T cells generate CXCL9/10-producing T-bet
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Type 1 helper T cells generate CXCL9/10-producing T-bet
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th1 › Type 1 helper T cells generate CXCL9/10-producing T-bet