Synthetic carbohydrate-based HIV-1 vaccines.

AIDS Vaccines / administration & dosage Animals Antibodies, Viral / immunology Broadly Neutralizing Antibodies / immunology Disease Models, Animal Drug Design Epitopes / immunology HIV Envelope Protein gp120 / immunology HIV Infections / immunology HIV-1 / immunology Humans Immunogenicity, Vaccine Macaca Mannose / chemistry Protein Domains / immunology Vaccines, Synthetic / administration & dosage

Journal

Drug discovery today. Technologies
ISSN: 1740-6749
Titre abrégé: Drug Discov Today Technol
Pays: England
ID NLM: 101235076

Informations de publication

Date de publication:
Dec 2020
Historique:
received: 25 07 2020
revised: 15 09 2020
accepted: 22 09 2020
entrez: 3 1 2021
pubmed: 4 1 2021
medline: 21 9 2021
Statut: ppublish

Résumé

An effective prophylactic HIV-1 vaccine is essential in order to contain the HIV/AIDS global pandemic. The discovery of different broadly neutralizing antibodies (bnAbs) in the last decades has enabled the characterization of several minimal epitopes on the HIV envelope (Env) spike, including glycan-dependent fragments. Herein, we provide a brief overview of the progress made on the development of synthetic carbohydrate-based epitope mimics for the elicitation of bnAbs directed to certain regions on Env gp120 protein: the outer domain high-mannose cluster and the variable loops V1V2 and V3. We focus on the design, synthesis and biological evaluation of minimal immunogens and discuss key aspects towards the development of a successful protective vaccine against HIV-1.

Identifiants

DOI: 10.1016/j.ddtec.2020.09.004 PMID: 33388127
pubmed: 33388127
pii: S1740-6749(20)30016-0
doi: 10.1016/j.ddtec.2020.09.004
pii:
doi:

Substances chimiques

AIDS Vaccines 0
Antibodies, Viral 0
Broadly Neutralizing Antibodies 0
Epitopes 0
HIV Envelope Protein gp120 0
Vaccines, Synthetic 0
gp120 protein, Human immunodeficiency virus 1 0
Mannose PHA4727WTP

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

45-56

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Iñaki Bastida (I)

Chemical Immunology Lab, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48169 Derio, Bizkaia, Spain.

Alberto Fernández-Tejada (A)

Chemical Immunology Lab, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48169 Derio, Bizkaia, Spain; Ikerbasque, Basque Foundation for Science, María Díaz de Haro 13, 48013 Bilbao, Bizkaia, Spain. Electronic address: afernandeztejada@cicbiogune.es.

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Classifications MeSH

questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiviraux › Vaccins contre le SIDA › Synthetic carbohydrate-based HIV-1 vaccines.
questionsmedicales.fr › Eucaryotes › Animaux › Synthetic carbohydrate-based HIV-1 vaccines.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Synthetic carbohydrate-based HIV-1 vaccines.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › Anticorps neutralisants à large spectre › Synthetic carbohydrate-based HIV-1 vaccines.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Synthetic carbohydrate-based HIV-1 vaccines.
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Synthetic carbohydrate-based HIV-1 vaccines.
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Synthetic carbohydrate-based HIV-1 vaccines.
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes viraux › Antigènes du VIH › Protéine d'enveloppe gp120 du VIH › Synthetic carbohydrate-based HIV-1 vaccines.
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Synthetic carbohydrate-based HIV-1 vaccines.
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Synthetic carbohydrate-based HIV-1 vaccines.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthetic carbohydrate-based HIV-1 vaccines.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunogénicité des vaccins › Synthetic carbohydrate-based HIV-1 vaccines.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Synthetic carbohydrate-based HIV-1 vaccines.
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Mannose › Synthetic carbohydrate-based HIV-1 vaccines.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › Synthetic carbohydrate-based HIV-1 vaccines.
questionsmedicales.fr › Facteurs biologiques › Antigènes › Vaccins synthétiques › Synthetic carbohydrate-based HIV-1 vaccines.