Mechanism of seizure-induced retrograde amnesia.

Amnesia, Retrograde / etiology CA1 Region, Hippocampal Excitatory Postsynaptic Potentials Hippocampus Humans Neuronal Plasticity Pyramidal Cells Seizures / complications Synapses
EPSC Engram LTP Seizure T maze TRAP

Journal

Progress in neurobiology
ISSN: 1873-5118
Titre abrégé: Prog Neurobiol
Pays: England
ID NLM: 0370121

Informations de publication

Date de publication:
05 2021
Historique:
received: 28 07 2020
revised: 09 12 2020
accepted: 22 12 2020
pubmed: 4 1 2021
medline: 15 2 2022
entrez: 3 1 2021
Statut: ppublish

Résumé

Seizures cause retrograde amnesia, but underlying mechanisms are poorly understood. We tested whether seizure activated neuronal circuits overlap with spatial memory engram and whether seizures saturate LTP in engram cells. A seizure caused retrograde amnesia for spatial memory task. Spatial learning and a seizure caused cFos expression and synaptic plasticity overlapping set of neurons in the CA1 of the hippocampus. Recordings from learning-labeled CA1 pyramidal neurons showed potentiated synapses. Seizure-tagged neurons were also more excitable with larger rectifying excitatory postsynaptic currents than surrounding unlabeled neurons. These neurons had enlarged dendritic spines and saturated LTP. A seizure immediately after learning, reset the memory engram. Seizures cause retrograde amnesia through shared ensembles and mechanisms.

Identifiants

DOI: 10.1016/j.pneurobio.2020.101984 PMID: 33388373 PMC: PMC8026600
pubmed: 33388373
pii: S0301-0082(20)30239-2
doi: 10.1016/j.pneurobio.2020.101984
pmc: PMC8026600
mid: NIHMS1660834
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

101984

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS044370
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS040337
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS104670
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS120945
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS092548
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

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Auteurs

Aijaz Ahmad Naik (AA)

Department of Neurology, University of Virginia, Charlottesville, VA, USA.

Huayu Sun (H)

UVA Brain Institute, University of Virginia, Charlottesville, VA, USA.

Cedric L Williams (CL)

Department of Psychology, University of Virginia, Charlottesville, VA, USA.

Daniel S Weller (DS)

Department of Electrical and Computer Engineering, University of Virginia, USA.

J Julius Zhu (J)

Department of Pharmacology, University of Virginia, Charlottesville, VA, USA.

Jaideep Kapur (J)

Department of Neurology, University of Virginia, Charlottesville, VA, USA; UVA Brain Institute, University of Virginia, Charlottesville, VA, USA; Department of Neuroscience, University of Virginia, Charlottesville, VA, USA. Electronic address: jk8t@virginia.edu.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Amnésie › Amnésie rétrograde › Mechanism of seizure-induced retrograde amnesia.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Région CA1 de l'hippocampe › Mechanism of seizure-induced retrograde amnesia.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Potentiels synaptiques › Potentiels post-synaptiques excitateurs › Mechanism of seizure-induced retrograde amnesia.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Mechanism of seizure-induced retrograde amnesia.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mechanism of seizure-induced retrograde amnesia.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Mechanism of seizure-induced retrograde amnesia.
questionsmedicales.fr › Cellules › Neurones › Cellules pyramidales › Mechanism of seizure-induced retrograde amnesia.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Crises épileptiques › Mechanism of seizure-induced retrograde amnesia.
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Mechanism of seizure-induced retrograde amnesia.