Natural Products in Cancer Therapy: Past, Present and Future.
Antibody–drug conjugates
Cancer therapy
Combination therapy
Drug discovery
Natural products
Journal
Natural products and bioprospecting
ISSN: 2192-2195
Titre abrégé: Nat Prod Bioprospect
Pays: Germany
ID NLM: 101577734
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
15
10
2020
accepted:
15
12
2020
pubmed:
4
1
2021
medline:
4
1
2021
entrez:
3
1
2021
Statut:
ppublish
Résumé
Natural products, with remarkable chemical diversity, have been extensively investigated for their anticancer potential for more than a half-century. The collective efforts of the community have achieved the tremendous advancements, bringing natural products to clinical use and discovering new therapeutic opportunities, yet the challenges remain ahead. With remarkable changes in the landscape of cancer therapy and growing role of cutting-edge technologies, we may have come to a crossroads to revisit the strategies to understand nature products and to explore their therapeutic utility. This review summarizes the key advancements in nature product-centered cancer research and calls for the implementation of systematic approaches, new pharmacological models, and exploration of emerging directions to revitalize natural products search in cancer therapy.
Identifiants
pubmed: 33389713
doi: 10.1007/s13659-020-00293-7
pii: 10.1007/s13659-020-00293-7
pmc: PMC7933288
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
5-13Références
ACS Chem Biol. 2017 Aug 18;12(8):2040-2050
pubmed: 28636309
Oncogene. 2015 Jun;34(25):3215-25
pubmed: 25220419
Nat Prod Rep. 2016 May 4;33(5):612-20
pubmed: 26580476
J Clin Oncol. 2005 Nov 1;23(31):7794-803
pubmed: 16172456
J Nat Prod. 2004 Feb;67(2):129-35
pubmed: 14987046
Blood. 2011 Jun 16;117(24):6425-37
pubmed: 21422471
Nat Prod Rep. 2016 May 4;33(5):719-30
pubmed: 26964663
J Mol Med (Berl). 2012 Aug;90(8):971-81
pubmed: 22406864
Cell Chem Biol. 2017 Nov 16;24(11):1368-1376.e4
pubmed: 28919038
Chin J Nat Med. 2015 Jan;13(1):3-21
pubmed: 25660284
Cancer Res. 2010 Mar 15;70(6):2235-44
pubmed: 20215499
Nat Rev Cancer. 2006 Oct;6(10):789-802
pubmed: 16990856
Med Res Rev. 1998 Sep;18(5):299-314
pubmed: 9735871
Blood. 1999 Nov 15;94(10):3315-24
pubmed: 10552940
J Cell Physiol. 2019 May;234(5):5628-5642
pubmed: 30478951
Clin Pharmacol Ther. 2013 Apr;93(4):299-301
pubmed: 23511784
Expert Opin Pharmacother. 2006 Jun;7(8):1041-53
pubmed: 16722814
J Nat Prod. 2020 Mar 27;83(3):770-803
pubmed: 32162523
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Angew Chem Int Ed Engl. 2020 Feb 3;59(6):2429-2439
pubmed: 31782597
J Immunother Cancer. 2020 Mar;8(1):
pubmed: 32179631
Nat Cell Biol. 2016 Oct;18(10):1065-77
pubmed: 27617930
Blood. 2019 Apr 11;133(15):1630-1643
pubmed: 30803991
Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5328-35
pubmed: 15044693
J Med Chem. 2008 Aug 14;51(15):4419-29
pubmed: 18610999
Cell. 2016 Apr 7;165(2):276-87
pubmed: 27058662
Nat Rev Drug Discov. 2017 May;16(5):315-337
pubmed: 28303026
Bioorg Med Chem Lett. 2017 Feb 15;27(4):701-707
pubmed: 28073672
Blood. 2010 Nov 11;116(19):3751-7
pubmed: 20705755
Cancer Cell. 2018 Apr 9;33(4):570-580
pubmed: 29634945
Curr Top Microbiol Immunol. 2019;420:351-374
pubmed: 30105423
J Ethnopharmacol. 1996 Apr;51(1-3):239-53; discussion 253-4
pubmed: 9213622
Eur J Immunol. 2019 Dec;49(12):2235-2244
pubmed: 31465113
Nat Chem Biol. 2019 Jul;15(7):747-755
pubmed: 31209351
Clin Cancer Res. 2007 Feb 15;13(4):1298-307
pubmed: 17287296
J Biol Chem. 2018 Apr 6;293(14):5335-5344
pubmed: 29462785
Cancer Cell. 2010 Jul 13;18(1):88-98
pubmed: 20609355
Evid Based Complement Alternat Med. 2019 Apr 15;2019:2682748
pubmed: 31118952
Nat Prod Rep. 2016 May 4;33(5):681-708
pubmed: 27098809
Sci Transl Med. 2010 Aug 18;2(45):45ra59
pubmed: 20720216
Science. 2010 Apr 9;328(5975):240-3
pubmed: 20378816
J Med Chem. 2020 Aug 27;63(16):8651-8652
pubmed: 32639156
Nat Prod Rep. 2021 Mar 4;38(2):346-361
pubmed: 32869826
J Med Chem. 2012 Sep 27;55(18):8183-7
pubmed: 22934600
Nat Rev Cancer. 2010 Nov;10(11):775-83
pubmed: 20966922
Nat Cell Biol. 2008 May;10(5):547-55
pubmed: 18408733
Future Med Chem. 2016 Jan;8(1):17-27
pubmed: 26689493
Chin Med. 2018 Jul 4;13:35
pubmed: 29997684
Nat Cell Biol. 2008 May;10(5):538-46
pubmed: 18408734
Trends Mol Med. 2012 Jan;18(1):36-42
pubmed: 22056243
Cancer Res. 1995 Feb 15;55(4):753-60
pubmed: 7850785
Clin Cancer Res. 2004 Dec 15;10(24):8266-74
pubmed: 15623602
Nat Rev Drug Discov. 2013 May;12(5):329-32
pubmed: 23629491