The Natural Compound Oblongifolin C Exhibits Anticancer Activity by Inhibiting HSPA8 and Cathepsin B

HSPA8 cathepsin B natural compounds oblongifolin C protein fishing

Journal

Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923

Informations de publication

Date de publication:
2020
Historique:
received: 22 05 2020
accepted: 19 10 2020
entrez: 4 1 2021
pubmed: 5 1 2021
medline: 5 1 2021
Statut: epublish

Résumé

PPAPs (Polycyclic polyprenylated acylphloroglucinols) are a class of compounds with diverse bioactivities, including anticancer effects. Oblongifolin C (OC) is a PPAP isolated from the plant of

Identifiants

pubmed: 33390942
doi: 10.3389/fphar.2020.564833
pii: 564833
pmc: PMC7773843
doi:

Types de publication

Journal Article

Langues

eng

Pagination

564833

Informations de copyright

Copyright © 2020 Han, Xu, Hi, Wu, Nik Nabil, Zhang, Sui, Fu, Zhou, Lao, Xu, Guo and Xu.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Li Han (L)

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Danqing Xu (D)

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Zhichao Xi (Z)

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Man Wu (M)

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Wan Najbah Nik Nabil (WN)

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Juan Zhang (J)

School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Hua Sui (H)

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Wenwei Fu (W)

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Hua Zhou (H)

Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Yuanzhi Lao (Y)

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Gang Xu (G)

State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of National Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.

Cheng Guo (C)

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Hongxi Xu (H)

Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Classifications MeSH