Adipose Tissue SIRT1 Regulates Insulin Sensitizing and Anti-Inflammatory Effects of Berberine.
SIRT1
acetylation
adipose tissue
berberine
inflammation
insulin resistance
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
08
2020
accepted:
27
11
2020
entrez:
4
1
2021
pubmed:
5
1
2021
medline:
5
1
2021
Statut:
epublish
Résumé
Berberine (BBR), which is an active component of Coptis chinensis Franch, has been reported to improve glucose metabolism and insulin resistance in animal and human studies, predominantly via activation of the 5'-adenosine monophosphate kinase (AMPK) pathway and suppression of the inflammation response. However, the mechanisms underlying the effects of BBR on AMPK and inflammation remain unclear. In this present study, we found that BBR upregulated SIRT1 expression in 3T3L-1 adipocytes and adipose tissue. Inhibition of SIRT1 blunted the BBR-induced increase in glucose consumption and uptake in adipocytes. The BBR-induced activation of the AMPK pathway and AKT phosphorylation in adipocytes and adipose tissue were also attenuated by inhibition or knockout of
Identifiants
pubmed: 33390968
doi: 10.3389/fphar.2020.591227
pii: 591227
pmc: PMC7774030
doi:
Types de publication
Journal Article
Langues
eng
Pagination
591227Informations de copyright
Copyright © 2020 Shan, Zhang, Gao, Liang, Zhang, Yu, Zhao, Ye, Yang and Shang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Endocrinol. 2015 Feb;224(2):109-18
pubmed: 25349250
Biochim Biophys Acta. 2012 Feb;1822(2):185-95
pubmed: 22027215
Mol Cell Endocrinol. 2010 Apr 12;317(1-2):148-53
pubmed: 20036710
Evid Based Complement Alternat Med. 2014;2014:289264
pubmed: 24669227
J Diabetes Complications. 2016 Jan-Feb;30(1):178-83
pubmed: 26422395
Nature. 2005 Mar 3;434(7029):113-8
pubmed: 15744310
Oxid Med Cell Longev. 2019 Dec 6;2019:2150394
pubmed: 31885776
Nat Commun. 2014 Nov 25;5:5493
pubmed: 25423280
Exp Mol Med. 2006 Dec 31;38(6):599-605
pubmed: 17202835
Zhongguo Zhong Yao Za Zhi. 2010 Jun;35(11):1474-7
pubmed: 20822024
J Nutr Biochem. 2018 May;55:209-218
pubmed: 29554499
J Biol Chem. 2005 Apr 22;280(16):16456-60
pubmed: 15716268
Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E148-56
pubmed: 17971514
Front Pharmacol. 2018 Aug 21;9:557
pubmed: 30186157
J Endocrinol. 2014 Sep;222(3):R113-27
pubmed: 25006217
Int Immunopharmacol. 2017 Nov;52:93-100
pubmed: 28888780
FEBS Lett. 2008 Jan 9;582(1):46-53
pubmed: 18036349
Pharmacol Res. 2013 Jan;67(1):60-7
pubmed: 23098819
Metabolism. 2007 Mar;56(3):405-12
pubmed: 17292731
Cell. 2013 Feb 14;152(4):673-84
pubmed: 23415219
Cell Metab. 2006 May;3(5):333-41
pubmed: 16679291
Diabetes Metab J. 2013 Oct;37(5):315-25
pubmed: 24199159
Diabetes. 2007 Oct;56(10):2467-75
pubmed: 17646210
J Nutr Health Aging. 2018;22(6):710-717
pubmed: 29806860
Phytother Res. 2016 Nov;30(11):1745-1764
pubmed: 27528198
Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E955-64
pubmed: 19208854
Annu Rev Physiol. 2010;72:219-46
pubmed: 20148674
J Biochem Biophys Methods. 2005 Sep 30;64(3):207-15
pubmed: 16182371
Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E419-28
pubmed: 19996381
Biochem Cell Biol. 2015 Oct;93(5):479-86
pubmed: 25607236
J Nat Med. 2018 Jun;72(3):715-723
pubmed: 29680964
J Endocrinol. 2008 Sep;198(3):561-9
pubmed: 18550785
Chin Med. 2018 Mar 7;13:13
pubmed: 29541156
Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E812-9
pubmed: 19176354
Cells. 2019 Jun 23;8(6):
pubmed: 31234575
Metabolism. 2013 Aug;62(8):1159-67
pubmed: 23537779
Oxid Med Cell Longev. 2020 Mar 9;2020:1452696
pubmed: 32215168
J Physiol Biochem. 2013 Jun;69(2):165-75
pubmed: 22941749
ISRN Inflamm. 2013 Dec 22;2013:139239
pubmed: 24455420
Endocrinology. 2010 Jun;151(6):2504-14
pubmed: 20339025
Cell Metab. 2012 May 2;15(5):675-90
pubmed: 22560220
J Clin Invest. 2013 Jul;123(7):2764-72
pubmed: 23863634
Annu Rev Nutr. 2012 Aug 21;32:261-86
pubmed: 22404118
J Clin Invest. 2017 Jan 3;127(1):5-13
pubmed: 28045397
Life Sci. 2016 Dec 1;166:82-91
pubmed: 27702567
EMBO Rep. 2017 Apr;18(4):645-657
pubmed: 28270525
Biomed Pharmacother. 2018 May;101:805-819
pubmed: 29525677
Front Pharmacol. 2020 Feb 18;11:41
pubmed: 32132921
J Biol Chem. 2010 Jun 18;285(25):19051-9
pubmed: 20421294
Nat Rev Endocrinol. 2009 Jul;5(7):367-73
pubmed: 19455179
Br J Pharmacol. 2018 Jan;175(2):374-387
pubmed: 29065221
Annu Rev Med. 2005;56:45-62
pubmed: 15660501
Diabetes. 2006 Aug;55(8):2256-64
pubmed: 16873688
Mol Cell Biol. 2009 Mar;29(5):1363-74
pubmed: 19103747
Colloids Surf B Biointerfaces. 2020 Mar;187:110647
pubmed: 31761520