The Mysteries of Capsaicin-Sensitive Afferents.
TRPV1 receptor
capsaicin
inflammation
ion channel
pain
sensory neuron
thermoregulation
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
04
2020
accepted:
13
11
2020
entrez:
4
1
2021
pubmed:
5
1
2021
medline:
5
1
2021
Statut:
epublish
Résumé
A fundamental subdivision of nociceptive sensory neurons is named after their unique sensitivity to capsaicin, the pungent ingredient in hot chili peppers: these are the capsaicin-sensitive afferents. The initial excitation by capsaicin of these neurons manifested as burning pain sensation is followed by a lasting refractory state, traditionally referred to as "capsaicin desensitization," during which the previously excited neurons are unresponsive not only to capsaicin but a variety of unrelated stimuli including noxious heat. The long sought-after capsaicin receptor, now known as TRPV1 (transient receptor potential cation channel, subfamily V member 1), was cloned more than two decades ago. The substantial reduction of the inflammatory phenotype of
Identifiants
pubmed: 33391007
doi: 10.3389/fphys.2020.554195
pmc: PMC7772409
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
554195Informations de copyright
Copyright © 2020 Fischer, Ciotu and Szallasi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Biol Chem. 2012 Jun 1;287(23):19462-71
pubmed: 22493457
J Neurosci. 1988 Sep;8(9):3208-20
pubmed: 3171675
Hypertension. 2013 Jan;61(1):246-52
pubmed: 23150506
Acta Physiol (Oxf). 2018 Jul;223(3):e13038
pubmed: 29352512
J Transl Med. 2020 Jan 17;18(1):28
pubmed: 31952468
Temperature (Austin). 2015 May 22;2(2):297-301
pubmed: 27227030
Mol Pain. 2014 Nov 19;10:69
pubmed: 25406633
Pain. 2014 Apr;155(4):733-745
pubmed: 24434730
J Pain. 2008 Dec;9(12):1088-95
pubmed: 19038771
J Biol Chem. 2004 May 7;279(19):20283-95
pubmed: 14996838
Pain. 2010 Jun;149(3):522-528
pubmed: 20403666
Pharmacol Rev. 1999 Jun;51(2):159-212
pubmed: 10353985
Br J Pharmacol Chemother. 1967 Sep;31(1):138-51
pubmed: 6055248
J Neurosci. 2014 Jun 11;34(24):8246-58
pubmed: 24920628
FASEB J. 2020 Jan;34(1):287-302
pubmed: 31914619
Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3655-60
pubmed: 10725386
Nature. 2013 Dec 5;504(7478):113-8
pubmed: 24305161
Toxins (Basel). 2017 Oct 16;9(10):
pubmed: 29035314
Neuron. 2016 Dec 7;92(5):1079-1092
pubmed: 27840000
Pharm Hist. 2013;55(4):136-56
pubmed: 25654939
Trends Pharmacol Sci. 1990 Aug;11(8):330-3
pubmed: 2203194
Trends Pharmacol Sci. 2008 Nov;29(11):550-7
pubmed: 18805596
Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11342-11347
pubmed: 27638213
Curr Med Chem. 2019;26(34):6261-6281
pubmed: 29848264
Br J Pharmacol. 2018 Jun;175(12):2185-2203
pubmed: 28924972
Nature. 1999 Jul 29;400(6743):452-7
pubmed: 10440374
Neuroscience. 1988 Mar;24(3):739-68
pubmed: 3288903
Naunyn Schmiedebergs Arch Pharmacol. 1982 Jul;320(1):54-7
pubmed: 7121612
Skin Pharmacol Physiol. 2015;28(2):65-74
pubmed: 25277470
Pain Rep. 2018 Oct 26;3(6):e696
pubmed: 30706039
BJU Int. 2001 Sep;88(4):355-60
pubmed: 11564021
Pharmacol Ther. 2020 Apr;208:107474
pubmed: 31926897
Pain. 2019 Nov;160(11):2554-2565
pubmed: 31188268
J Med Chem. 2008 May 8;51(9):2744-57
pubmed: 18386885
Nature. 2018 Mar 29;555(7698):662-666
pubmed: 29539642
Elife. 2018 Jun 05;7:
pubmed: 29869983
Nat Rev Drug Discov. 2007 May;6(5):357-72
pubmed: 17464295
Brain Res. 1997 Mar 28;752(1-2):52-60
pubmed: 9106440
Pain. 1995 Mar;60(3):329-32
pubmed: 7596629
J Exp Biol. 2014 Dec 1;217(Pt 23):4167-73
pubmed: 25324339
Neuropharmacology. 2014 Oct;85:151-7
pubmed: 24887171
Blood. 1998 Feb 15;91(4):1332-40
pubmed: 9454764
Eur J Pain. 2010 May;14(5):480-6
pubmed: 19800272
J Neuroimmunol. 2004 Aug;153(1-2):171-82
pubmed: 15265675
J Neurosci. 2013 May 22;33(21):9184-9193
pubmed: 23699529
Neuropeptides. 2004 Dec;38(6):377-84
pubmed: 15567473
Science. 2007 Feb 16;315(5814):986-8
pubmed: 17303753
Acta Physiol Scand Suppl. 1995;629:1-68
pubmed: 8801775
Pain. 2018 Jul;159(7):1325-1345
pubmed: 29561359
Pain. 2016 Sep;157(9):2057-2067
pubmed: 27168361
Br J Pharmacol. 2004 Feb;141(4):737-45
pubmed: 14757700
J Pain. 2010 Jun;11(6):579-87
pubmed: 20400377
J Pain. 2014 Dec;15(12):1338-1359
pubmed: 25281809
EMBO J. 2005 Dec 21;24(24):4211-23
pubmed: 16319926
Pain. 1989 Jul;38(1):99-107
pubmed: 2780068
J Biol Chem. 2012 Jan 20;287(4):2388-97
pubmed: 22130664
Neuroreport. 2007 Jul 2;18(10):969-73
pubmed: 17558279
Nature. 2010 Apr 15;464(7291):1006-11
pubmed: 20228791
Physiol Behav. 1984 Jun;32(6):995-8
pubmed: 6494313
J Neurochem. 2006 Nov;99(4):1088-102
pubmed: 17018028
Pflugers Arch. 1996 Apr;431(6):828-37
pubmed: 8927498
Eur J Pharmacol. 2020 Nov 15;887:173356
pubmed: 32763303
Drugs. 2018 Sep;78(14):1489-1500
pubmed: 30251173
Nature. 2000 Dec 21-28;408(6815):985-90
pubmed: 11140687
Nature. 2016 May 18;534(7607):347-51
pubmed: 27281200
Food Chem. 2016 Nov 1;210:606-12
pubmed: 27211688
Nat Rev Drug Discov. 2011 Aug 01;10(8):601-20
pubmed: 21804597
Pharmacol Rev. 1991 Jun;43(2):143-201
pubmed: 1852779
Brain. 2000 Mar;123 Pt 3:560-71
pubmed: 10686178
J Neurophysiol. 2002 Jul;88(1):544-8
pubmed: 12091579
J Biol Chem. 2005 Apr 8;280(14):13424-32
pubmed: 15691846
Mol Pain. 2008 Mar 01;4:9
pubmed: 18312687
J Neurophysiol. 2015 May 1;113(9):3345-55
pubmed: 25787958
Br J Pharmacol. 1997 Aug;121(7):1461-7
pubmed: 9257928
J Biol Chem. 2001 Apr 6;276(14):11021-30
pubmed: 11124944
Cell. 2002 Feb 8;108(3):421-30
pubmed: 11853675
Brain Res. 1990 Jul 30;524(1):106-11
pubmed: 2400923
Pflugers Arch. 2015 Sep;467(9):1851-69
pubmed: 25754030
Pain Rep. 2018 Mar 02;3(2):e644
pubmed: 29756090
J Neurophysiol. 1998 Dec;80(6):2801-10
pubmed: 9862885
Mol Pain. 2011 Jun 06;7:44
pubmed: 21645329
Arzneimittelforschung. 1975;25(12):1877-81
pubmed: 1243658
Aging (Albany NY). 2011 Apr;3(4):450-4
pubmed: 21483038
Science. 1985 Nov 29;230(4729):1040-3
pubmed: 3933112
Eur J Neurosci. 2007 Jun;25(12):3570-5
pubmed: 17610576
EMBO J. 2011 Mar 16;30(6):994-1002
pubmed: 21285946
Nature. 2011 Aug 03;476(7358):88-91
pubmed: 21814281
FEBS Lett. 2008 Jun 25;582(15):2257-62
pubmed: 18503767
Somatosens Mot Res. 2000;17(1):5-12
pubmed: 10833080
J Biol Chem. 2002 Apr 19;277(16):13375-8
pubmed: 11884385
Naunyn Schmiedebergs Arch Pharmacol. 1984 Mar;325(3):193-7
pubmed: 6145098
Lancet. 1997 Aug 30;350(9078):640-1
pubmed: 9288055
Neuron. 1998 Sep;21(3):531-43
pubmed: 9768840
Nature. 2000 May 11;405(6783):183-7
pubmed: 10821274
J Pain. 2017 Jun;18(6):726-738
pubmed: 28188907
Scand J Pain. 2018 Apr 25;18(2):151-164
pubmed: 29794306
Prog Drug Res. 2014;68:39-76
pubmed: 24941664
J Pharmacol Exp Ther. 2005 Apr;313(1):474-84
pubmed: 15615864
EMBO J. 2011 Feb 2;30(3):582-93
pubmed: 21139565
Nat Commun. 2014 Jun 20;5:4122
pubmed: 24947823
J Neurophysiol. 2003 Jan;89(1):513-24
pubmed: 12522198
J Biol Chem. 2010 May 14;285(20):15167-15177
pubmed: 20231274
J Clin Invest. 2004 May;113(9):1344-52
pubmed: 15124026
Nat Neurosci. 2013 Feb;16(2):174-82
pubmed: 23263443
Nature. 1997 Oct 23;389(6653):816-24
pubmed: 9349813
Sci Rep. 2015 Jul 21;5:12278
pubmed: 26194846
Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E317-E324
pubmed: 29279388
Pflugers Arch. 2014 Dec;466(12):2229-41
pubmed: 24643480
Pain. 2006 Jul;123(1-2):106-16
pubmed: 16564619
J Neurocytol. 1990 Oct;19(5):789-801
pubmed: 2077115
Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5170-5175
pubmed: 30804201
J Physiol. 2001 Aug 1;534(Pt 3):813-25
pubmed: 11483711
Mol Pain. 2013 May 13;9:24
pubmed: 23668392
Adv Pharmacol Sci. 2016;2016:1512457
pubmed: 26884754
Neuroscience. 1989;30(2):515-20
pubmed: 2747924
Mol Pain. 2011 Jan 10;7:4
pubmed: 21219650
Curr Neuropharmacol. 2006 Jul;4(3):197-206
pubmed: 18615146
Biochem J. 2003 Apr 15;371(Pt 2):341-50
pubmed: 12513687
Nature. 1969 Oct 18;224(5216):285-7
pubmed: 5344615
Temperature (Austin). 2016 Jan 19;3(1):54-5
pubmed: 27227097
Nat Commun. 2019 May 13;10(1):2134
pubmed: 31086183
Scand J Pain. 2017 Dec 29;4(3):138-145
pubmed: 29913914
Am J Respir Crit Care Med. 2017 Nov 15;196(10):1255-1263
pubmed: 28650204
Neurosci Lett. 1988 May 26;88(2):201-5
pubmed: 2454437
Neurosci Lett. 1998 Jul 10;250(3):177-80
pubmed: 9708861
J Pharmacol Exp Ther. 2005 Sep;314(3):1378-85
pubmed: 15947039
Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8134-9
pubmed: 10859346
PLoS Biol. 2018 Jul 12;16(7):e2004921
pubmed: 30001322
Science. 2008 Aug 1;321(5889):702-5
pubmed: 18669863
Brain Res. 1987 Aug 18;418(1):201-3
pubmed: 3664271
Eur J Neurosci. 2003 Aug;18(4):803-10
pubmed: 12925006
Temperature (Austin). 2015 Jun 02;2(2):277-96
pubmed: 27227029
Cells. 2014 May 23;3(2):517-45
pubmed: 24861977
Pain. 2006 Aug;123(3):231-243
pubmed: 16697110
Arthritis Rheumatol. 2019 Sep;71(9):1524-1533
pubmed: 30888737
J Pain. 2017 May;18(5):526-534
pubmed: 28062311
Eur J Neurosci. 2004 Mar;19(5):1421-4
pubmed: 15016100
J Neurosci. 2013 Mar 27;33(13):5533-41
pubmed: 23536068
Nat Med. 2018 May;24(4):417-426
pubmed: 29505031
Biochem Biophys Res Commun. 2020 Jan 22;521(4):914-920
pubmed: 31711646
Toxins (Basel). 2020 Apr 05;12(4):
pubmed: 32260499
Naunyn Schmiedebergs Arch Pharmacol. 1975;287(2):157-69
pubmed: 1143357
Nature. 2003 Dec 4;426(6966):517-24
pubmed: 14654832
Med Res Rev. 2017 Jul;37(4):936-983
pubmed: 27976413
J Neurosci. 2007 Nov 21;27(47):12797-807
pubmed: 18032651
Pharmacol Rev. 2012 Oct;64(4):939-71
pubmed: 23023032
J Neurosci. 2013 Jan 2;33(1):315-26
pubmed: 23283344
Temperature (Austin). 2017 Apr 14;4(2):97-100
pubmed: 28680919
Pain. 1998 Feb;74(2-3):257-68
pubmed: 9520240
Nature. 2013 Dec 5;504(7478):107-12
pubmed: 24305160
Cochrane Database Syst Rev. 2012 Sep 12;(9):CD010111
pubmed: 22972149
J Pharmacol Exp Ther. 2003 Jul;306(1):377-86
pubmed: 12721338
Exp Brain Res. 2018 Aug;236(8):2231-2244
pubmed: 29845449
J Pain. 2007 Mar;8(3):263-72
pubmed: 17113352
Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):364-7
pubmed: 9303574
J Neurophysiol. 2004 Jun;91(6):2770-81
pubmed: 14762154
Scand J Pain. 2017 Oct;17:134-143
pubmed: 28850367
Pain. 2019 Feb;160(2):508-527
pubmed: 30335684
J Appl Physiol (1985). 1989 Oct;67(4):1428-37
pubmed: 2793745
Proc Natl Acad Sci U S A. 2000 May 23;97(11):6155-60
pubmed: 10823958
J Peripher Nerv Syst. 1996;1(1):6-18
pubmed: 10970115
J Comp Neurol. 1992 Apr 1;318(1):103-16
pubmed: 1583153
PLoS One. 2011;6(7):e22246
pubmed: 21779403
J Med Assoc Thai. 2009 Jan;92(1):108-13
pubmed: 19260251
Eur J Neurosci. 2004 Nov;20(9):2303-10
pubmed: 15525272
Pain. 2015 May;156(5):931-941
pubmed: 25734989
Bioorg Med Chem. 2001 Jan;9(1):19-32
pubmed: 11197340
Elife. 2017 May 24;6:
pubmed: 28537555
Nat Neurosci. 2015 Jan;18(1):145-53
pubmed: 25420068
Science. 2000 Apr 14;288(5464):306-13
pubmed: 10764638
Neurosci Lett. 1991 Dec 16;134(1):9-11
pubmed: 1726117
Cell Mol Neurobiol. 2014 May;34(4):565-76
pubmed: 24590823
Sci Rep. 2016 Jun 30;6:28621
pubmed: 27356469
Pain. 2001 Feb 1;90(1-2):97-103
pubmed: 11166975
J Neurosci. 2013 Apr 24;33(17):7407-14
pubmed: 23616546
J Neurosci. 2011 Mar 30;31(13):5067-77
pubmed: 21451044
J Comp Neurol. 2005 Dec 26;493(4):596-606
pubmed: 16304633
Pain. 2000 Nov;88(2):205-215
pubmed: 11050376
J Neurosci. 2013 Mar 20;33(12):5249-60
pubmed: 23516290
Mol Pharmacol. 1999 Sep;56(3):581-7
pubmed: 10462546
Anesthesiology. 2016 May;124(5):1153-65
pubmed: 26859646
Trends Neurosci. 2009 Apr;32(4):215-24
pubmed: 19285736
J Physiol. 1970 Mar;206(3):495-507
pubmed: 5498502
Percept Psychophys. 1986 May;39(5):346-50
pubmed: 3737366
J Allergy Clin Immunol. 2014 Jul;134(1):56-62
pubmed: 24666696
Eur J Neurosci. 2001 Jun;13(11):2177-82
pubmed: 11422460
Food Qual Prefer. 2013 Apr 1;28(1):213-221
pubmed: 23538555
Br J Pharmacol. 2012 May;166(2):510-21
pubmed: 22233379
J Gen Physiol. 2015 Aug;146(2):147-59
pubmed: 26170176
Mol Cell Neurosci. 2015 Mar;65:1-10
pubmed: 25662734
J Cell Physiol. 2017 Aug;232(8):1957-1965
pubmed: 27891582
Cell. 2015 Feb 12;160(4):759-770
pubmed: 25679765
Mol Pain. 2010 Dec 17;6:94
pubmed: 21167052
Open Pain J. 2013;6:95-107
pubmed: 26779292
J Biol Chem. 2004 Apr 16;279(16):16377-87
pubmed: 14963041
Pain Med. 2013 Aug;14(8):1202-11
pubmed: 23710678
Nature. 2004 Aug 12;430(7001):748-54
pubmed: 15306801
J Neurosci. 2007 Mar 7;27(10):2435-43
pubmed: 17344381
Clin Sci (Lond). 1986 Nov;71(5):519-26
pubmed: 3769402
J Pain Res. 2012;5:51-9
pubmed: 22536092
Trends Neurosci. 1994 Jan;17(1):22-30
pubmed: 7511846
Handb Exp Pharmacol. 2014;223:v - vi
pubmed: 25296415
Pain. 2004 Jul;110(1-2):215-9
pubmed: 15275770
Cell Res. 2016 Jan;26(1):83-102
pubmed: 26691752
Neuron. 2002 Aug 15;35(4):721-31
pubmed: 12194871
Eur J Pain. 2014 May;18(5):671-9
pubmed: 24259265
Pain. 1999 May;81(1-2):25-33
pubmed: 10353490
J Pharmacol Exp Ther. 2008 Jul;326(1):218-29
pubmed: 18420600
J Biol Chem. 2017 May 19;292(20):8291-8303
pubmed: 28360106
J Biol Chem. 2009 Nov 20;284(47):32591-601
pubmed: 19778904
Pharmacol Toxicol. 1999 Feb;84(2):66-71
pubmed: 10068149
PLoS One. 2017 Sep 28;12(9):e0185543
pubmed: 28957441
Cell. 2002 May 3;109(3):397-407
pubmed: 12015988
Biochem J. 2013 Apr 1;451(1):101-9
pubmed: 23360390