microRNA-155 Is Decreased During Atherosclerosis Regression and Is Increased in Urinary Extracellular Vesicles During Atherosclerosis Progression.
Acute Coronary Syndrome
/ diagnostic imaging
Aged
Animals
Aortic Diseases
/ genetics
Atherosclerosis
/ genetics
Biomarkers
/ urine
Carotid Artery Diseases
/ genetics
Coronary Artery Disease
/ diagnostic imaging
Disease Models, Animal
Disease Progression
Extracellular Vesicles
/ genetics
Female
Humans
Macrophages
/ metabolism
Male
Mice, Inbred C57BL
Mice, Knockout, ApoE
MicroRNAs
/ genetics
Middle Aged
Phosphorylation
Proto-Oncogene Proteins c-bcl-6
/ metabolism
STAT3 Transcription Factor
/ metabolism
THP-1 Cells
extracellular vesicles
inflammation
macrophage
miR-155
microRNA
progression of atherosclerosis
regression of atherosclerosis
urine
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
06
2020
accepted:
22
10
2020
entrez:
4
1
2021
pubmed:
5
1
2021
medline:
16
6
2021
Statut:
epublish
Résumé
Atherosclerosis is a chronic inflammatory disease driven by macrophage accumulation in medium and large sized arteries. Macrophage polarization and inflammation are governed by microRNAs (miR) that regulate the expression of inflammatory proteins and cholesterol trafficking. Previous transcriptomic analysis led us to hypothesize that miR-155-5p (miR-155) is regulated by conjugated linoleic acid (CLA), a pro-resolving mediator which induces regression of atherosclerosis miR-155 expression was quantified in aortae from ApoE Here, we report that the 1% cholesterol diet increased miR-155 expression while CLA blend supplementation decreased miR-155 expression in the aorta during atherosclerosis regression miR-155 suppresses anti-inflammatory signaling in macrophages, is decreased during regression of atherosclerosis
Sections du résumé
Background
Atherosclerosis is a chronic inflammatory disease driven by macrophage accumulation in medium and large sized arteries. Macrophage polarization and inflammation are governed by microRNAs (miR) that regulate the expression of inflammatory proteins and cholesterol trafficking. Previous transcriptomic analysis led us to hypothesize that miR-155-5p (miR-155) is regulated by conjugated linoleic acid (CLA), a pro-resolving mediator which induces regression of atherosclerosis
Methods
miR-155 expression was quantified in aortae from ApoE
Results
Here, we report that the 1% cholesterol diet increased miR-155 expression while CLA blend supplementation decreased miR-155 expression in the aorta during atherosclerosis regression
Conclusion
miR-155 suppresses anti-inflammatory signaling in macrophages, is decreased during regression of atherosclerosis
Identifiants
pubmed: 33391256
doi: 10.3389/fimmu.2020.576516
pmc: PMC7773661
doi:
Substances chimiques
BCL6 protein, human
0
Biomarkers
0
MIRN155 microRNA, human
0
MicroRNAs
0
Mirn155 microRNA, mouse
0
Proto-Oncogene Proteins c-bcl-6
0
STAT3 Transcription Factor
0
STAT3 protein, human
0
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
576516Subventions
Organisme : Wellcome Trust
ID : 101604/Z/13/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Fitzsimons, Oggero, Bruen, McCarthy, Strowitzki, Mahon, Ryan, Brennan, Barry, Perretti and Belton.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Mol Nutr Food Res. 2010 Jan;54(1):17-36
pubmed: 19760681
J Am Heart Assoc. 2019 Jun 4;8(11):e012584
pubmed: 31433703
Proc Natl Acad Sci U S A. 2012 May 8;109(19):E1153-62
pubmed: 22509021
Front Immunol. 2020 Aug 04;11:1592
pubmed: 32849539
J Transl Med. 2018 Aug 14;16(1):228
pubmed: 30107841
J Biol Chem. 2012 Jun 22;287(26):21816-25
pubmed: 22549785
Mol Nutr Food Res. 2015 Sep;59(9):1865-78
pubmed: 26387852
Physiol Genomics. 2014 Feb 1;46(3):91-103
pubmed: 24326348
EBioMedicine. 2019 Jul;45:351-361
pubmed: 31229437
Genet Mol Res. 2015 Jun 26;14(2):6985-92
pubmed: 26125907
J Immunol Res. 2016;2016:6391264
pubmed: 27195303
J Inflamm (Lond). 2015 Feb 19;12:15
pubmed: 25722654
Fertil Steril. 2014 Dec;102(6):1751-61.e1
pubmed: 25241362
Proteomics. 2014 Aug;14(16):1922-32
pubmed: 24962155
Int J Mol Sci. 2019 Apr 24;20(8):
pubmed: 31022963
PLoS One. 2012;7(4):e35877
pubmed: 22558252
Nutr Metab Cardiovasc Dis. 2012 Nov;22(11):937-43
pubmed: 22748605
Nucleic Acids Res. 2019 Apr 23;47(7):3353-3364
pubmed: 30820533
J Immunol. 2010 Nov 15;185(10):6226-33
pubmed: 20937844
Cardiovasc Res. 2009 Jul 1;83(1):131-9
pubmed: 19377067
Int J Cardiol. 2016 Jan 1;202:756-9
pubmed: 26476027
Atherosclerosis. 2013 Apr;227(2):323-8
pubmed: 23422831
Korean J Intern Med. 2019 May;34(3):470-479
pubmed: 31048657
Eur J Immunol. 1991 Feb;21(2):425-9
pubmed: 1825635
J Intern Med. 2016 Mar;279(3):293-308
pubmed: 26620734
Sci Rep. 2020 Feb 28;10(1):3701
pubmed: 32111925
N Engl J Med. 2013 May 23;368(21):2004-13
pubmed: 23697515
Cell Physiol Biochem. 2016;40(3-4):668-680
pubmed: 27898407
Atherosclerosis. 2011 Nov;219(1):211-7
pubmed: 21820659
Front Immunol. 2016 Jul 19;7:275
pubmed: 27486460
Mediators Inflamm. 2016;2016:8060182
pubmed: 27843203
Gene. 2013 Dec 10;532(1):1-12
pubmed: 23246696
Curr Protoc Cell Biol. 2006 Apr;Chapter 3:Unit 3.22
pubmed: 18228490
Kidney Int Rep. 2017 Dec 01;3(3):555-572
pubmed: 29854963
Eur Heart J. 2016 Jun 07;37(22):1738-49
pubmed: 26916800
Exp Cell Res. 2018 Apr 1;365(1):78-84
pubmed: 29476835
Diabetes. 2017 Aug;66(8):2266-2277
pubmed: 28487436
J Transl Med. 2012 Jan 05;10:5
pubmed: 22221959
J Clin Invest. 2012 Nov;122(11):4190-202
pubmed: 23041630
Oxid Med Cell Longev. 2019 May 5;2019:4579806
pubmed: 31191799
J Mol Cell Biol. 2012 Oct;4(5):341-3
pubmed: 22831835
Clin Sci (Lond). 2020 Jan 31;134(2):169-192
pubmed: 31971230
J Extracell Vesicles. 2020 Jan 24;9(1):1713540
pubmed: 32128071
PLoS One. 2013 Nov 04;8(11):e73798
pubmed: 24223694
Int J Cardiol. 2016 Apr 1;208:147-9
pubmed: 26859321
Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):796-803
pubmed: 25810298
Blood. 2010 Oct 21;116(16):e74-80
pubmed: 20628149
JACC Basic Transl Sci. 2020 Jan 15;5(2):148-166
pubmed: 32140622
Cell Physiol Biochem. 2015;36(4):1371-81
pubmed: 26159489
J Biol Chem. 2010 Jul 2;285(27):20492-8
pubmed: 20435894
Antioxidants (Basel). 2018 Dec 19;7(12):
pubmed: 30572572
Kidney Blood Press Res. 2013;37(2-3):190-8
pubmed: 23736778
J Thromb Haemost. 2011 May;9(5):1056-66
pubmed: 21342432
Cell. 2005 Jan 14;120(1):15-20
pubmed: 15652477
FASEB J. 2013 Feb;27(2):499-510
pubmed: 23070607
Circ Cardiovasc Genet. 2012 Feb 1;5(1):122-31
pubmed: 22238190
Redox Biol. 2013 Nov 07;2:1-7
pubmed: 24363996
J Am Coll Cardiol. 2013 Oct 15;62(16):1436-41
pubmed: 23707318
Cytometry A. 2007 Nov;71(11):934-44
pubmed: 17879238
Cardiovasc Diabetol. 2017 Nov 6;16(1):143
pubmed: 29110715
Sci Rep. 2016 Feb 22;6:21789
pubmed: 26899994
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
Front Immunol. 2015 Feb 13;6:50
pubmed: 25762995
J Ovarian Res. 2018 Mar 2;11(1):20
pubmed: 29499737
FASEB J. 2010 Aug;24(8):2869-80
pubmed: 20354139
J Biol Chem. 2017 Jan 27;292(4):1267-1287
pubmed: 27856635
Curr Opin Pharmacol. 2009 Aug;9(4):514-20
pubmed: 19525145
J Transl Med. 2011 Jan 14;9:9
pubmed: 21235781
Atherosclerosis. 2006 Jul;187(1):40-9
pubmed: 16182300
Nat Commun. 2015 Aug 11;6:7847
pubmed: 26260587
FASEB J. 2019 Oct;33(10):11006-11020
pubmed: 31284764
BMC Cancer. 2016 Jul 07;16:419
pubmed: 27387344
Int Endod J. 2019 Jul;52(7):987-998
pubmed: 30703248
Immunity. 2009 Aug 21;31(2):220-31
pubmed: 19699171
Annu Rev Cell Dev Biol. 2014;30:255-89
pubmed: 25288114
Front Pharmacol. 2019 May 14;10:463
pubmed: 31139076
Cardiovasc Res. 2012 Mar 15;93(4):633-44
pubmed: 22258631
Circ Res. 2017 May 12;120(10):1649-1657
pubmed: 28495995
Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):759-67
pubmed: 24504735
J Immunol. 2001 Jun 15;166(12):7309-18
pubmed: 11390481
Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7113-8
pubmed: 19359473
Mol Ther Nucleic Acids. 2016 Oct 11;5(10):e374
pubmed: 27727247
Nutr Metab (Lond). 2015 Jun 06;12:21
pubmed: 26064180
Diabetologia. 2017 Mar;60(3):581-584
pubmed: 28004150