A thermosensitive, reactive oxygen species-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration in rats by inhibiting the secretory autophagy pathway.

Adult Aged Animals Autophagy / drug effects Female Fluorescent Antibody Technique Humans Hydrogels Interleukin-1beta / metabolism Intervertebral Disc Degeneration / diagnostic imaging Magnetic Resonance Imaging Male Mice Microtubule-Associated Proteins / metabolism Middle Aged Nucleus Pulposus / diagnostic imaging Peptide Fragments / pharmacology Rats Reactive Oxygen Species / metabolism THP-1 Cells Tripartite Motif Proteins / genetics Ubiquitin-Protein Ligases / genetics X-Ray Microtomography
MR409 ROS responsive carrier disc degeneration injectable hydrogel secretory autophagy

Journal

Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395

Informations de publication

Date de publication:
2021
Historique:
received: 03 05 2020
accepted: 18 09 2020
entrez: 4 1 2021
pubmed: 5 1 2021
medline: 6 8 2021
Statut: epublish

Résumé

Lumbar disc degeneration is a common cause of chronic low back pain and an important contributor to various degenerative lumbar spinal disorders. However, currently there is currently no effective therapeutic strategy for treating disc degeneration. The pro-inflammatory cytokine interleukin-1β (IL-1β) mediates disc degeneration by inducing apoptotic death of nucleus pulposus (NP) cells and degradation of the NP extracellular matrix. Here, we confirmed that extracellular secretion of IL-1β via secretory autophagy contributes to disc degeneration, and demonstrate that a thermosensitive reactive oxygen species (ROS)-responsive hydrogel loaded with a synthetic growth hormone-releasing hormone analog (MR409) can protect against needle puncture-induced disc degeneration in rats.

Identifiants

DOI: 10.7150/thno.47723 PMID: 33391467 PMC: PMC7681093
pubmed: 33391467
doi: 10.7150/thno.47723
pii: thnov11p0147
pmc: PMC7681093
doi:

Substances chimiques

(N-acetyl-tyr1,D-arg2)fragment 1-29 amide 0
Hydrogels 0
Interleukin-1beta 0
LC3 protein, rat 0
MAP1LC3B protein, human 0
Microtubule-Associated Proteins 0
Peptide Fragments 0
Reactive Oxygen Species 0
Tripartite Motif Proteins 0
TRIM16 protein, human EC 2.3.2.27
Ubiquitin-Protein Ligases EC 2.3.2.27

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

147-163

Informations de copyright

© The author(s).

Déclaration de conflit d'intérêts

Competing Interests: The authors have declared that no competing interest exists.

Références

J Am Heart Assoc. 2015 Mar 31;4(4):
pubmed: 25827134
Angew Chem Int Ed Engl. 2018 Jul 9;57(28):8463-8467
pubmed: 29757483
Arthritis Res Ther. 2015 Nov 05;17:316
pubmed: 26542776
Curr Opin Cell Biol. 2015 Aug;35:106-16
pubmed: 25988755
Cell Death Differ. 2006 Nov;13(11):1938-49
pubmed: 16575408
Nat Rev Rheumatol. 2014 Jan;10(1):44-56
pubmed: 24166242
Toxicol Appl Pharmacol. 2009 Sep 15;239(3):273-83
pubmed: 19524605
Bone Res. 2020 Feb 18;8:10
pubmed: 32133213
Science. 2019 Nov 15;366(6467):818-822
pubmed: 31727826
Biochim Biophys Acta. 2015 Jun;1848(6):1308-18
pubmed: 25753113
Cell. 2019 Jan 10;176(1-2):11-42
pubmed: 30633901
Nat Rev Mol Cell Biol. 2020 Jul;21(7):363-383
pubmed: 32231263
Spine (Phila Pa 1976). 2006 Aug 15;31(18):2151-61
pubmed: 16915105
Theranostics. 2018 Oct 22;8(19):5348-5361
pubmed: 30555551
J Orthop Res. 2011 Feb;29(2):265-9
pubmed: 20690185
Spine (Phila Pa 1976). 2005 Jan 1;30(1):5-14
pubmed: 15626974
J Orthop Res. 2018 Jan;36(1):224-232
pubmed: 28631843
Theranostics. 2019 Apr 12;9(8):2252-2267
pubmed: 31149042
Sci Adv. 2020 Apr 29;6(18):eaay9526
pubmed: 32494667
Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13248-13253
pubmed: 29180438
Ann N Y Acad Sci. 2017 Dec;1410(1):68-84
pubmed: 29265416
Nat Genet. 2005 Jun;37(6):607-12
pubmed: 15864306
BMJ. 2019 Oct 16;367:l5654
pubmed: 31619437
Eur J Immunol. 2013 Dec;43(12):3324-35
pubmed: 23963575
Theranostics. 2019 Oct 12;9(25):7506-7524
pubmed: 31695783
Adv Drug Deliv Rev. 2019 Sep - Oct;149-150:49-71
pubmed: 31445063
Biomaterials. 2017 Apr;123:127-141
pubmed: 28167391
EMBO J. 2013 Aug 28;32(17):2336-47
pubmed: 23921551
Cell Death Dis. 2016 Oct 27;7(10):e2441
pubmed: 27787519
Adv Colloid Interface Sci. 2017 Sep;247:589-609
pubmed: 28754381
Cell Death Dis. 2018 Sep 17;9(10):934
pubmed: 30224639
Theranostics. 2019 May 31;9(14):4084-4100
pubmed: 31281533
N Engl J Med. 2020 Mar 19;382(12):1093-1102
pubmed: 32187469
Spine (Phila Pa 1976). 2008 Aug 15;33(18):1925-34
pubmed: 18708924
J Innate Immun. 2013;5(5):471-9
pubmed: 23445716
Nat Rev Rheumatol. 2016 Oct;12(10):561
pubmed: 27539667
Lipids Health Dis. 2011 Jan 04;10:1
pubmed: 21199582
Front Physiol. 2014 Jul 15;5:259
pubmed: 25076911
Physiol Rev. 2019 Jan 1;99(1):311-379
pubmed: 30379623
Spine J. 2009 Mar;9(3):204-9
pubmed: 18495544
Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13651-6
pubmed: 26474831
Arthritis Res Ther. 2005;7(4):R732-45
pubmed: 15987475
Nat Rev Rheumatol. 2019 Feb;15(2):66
pubmed: 30622296
Autophagy. 2017 Jun 3;13(6):1084-1085
pubmed: 28368721
Dev Cell. 2016 Oct 10;39(1):13-27
pubmed: 27693506
Nat Rev Immunol. 2019 Mar;19(3):170-183
pubmed: 30531943
Sci Adv. 2018 Apr 04;4(4):eaaq0597
pubmed: 29632893
Oxid Med Cell Longev. 2017;2017:5601593
pubmed: 28392887
Spine (Phila Pa 1976). 2001 Sep 1;26(17):1873-8
pubmed: 11568697
J Cell Biol. 2002 Aug 5;158(3):463-73
pubmed: 12163469
Nat Rev Immunol. 2011 Aug 25;11(9):617-25
pubmed: 21866173
Pain. 2017 May;158(5):891-899
pubmed: 28114182
Spine J. 2013 Mar;13(3):331-41
pubmed: 23369495
J Cell Sci. 2012 Nov 15;125(Pt 22):5251-5
pubmed: 23377655
Theranostics. 2019 Sep 21;9(23):7016-7032
pubmed: 31660084
J Bone Joint Surg Am. 2006 Apr;88 Suppl 2:3-9
pubmed: 16595435
EMBO J. 2017 Jan 4;36(1):42-60
pubmed: 27932448
Autophagy. 2019 Oct;15(10):1682-1693
pubmed: 30894055
Circ Res. 2018 May 11;122(10):1395-1408
pubmed: 29618597
Biotechnol Adv. 2018 Jan - Feb;36(1):281-294
pubmed: 29199133
Lancet Neurol. 2018 Sep;17(9):802-815
pubmed: 30129476
Biotechnol J. 2017 Jan;12(1):
pubmed: 27420480
Eur Spine J. 2014 Jun;23 Suppl 3:S324-32
pubmed: 24482074
Ann Rheum Dis. 2017 Mar;76(3):576-584
pubmed: 27489225
J Orthop Res. 2011 Aug;29(8):1284-90
pubmed: 21387398
Science. 2017 Sep 8;357(6355):1047-1052
pubmed: 28751470
Nat Biomed Eng. 2019 Dec;3(12):998-1008
pubmed: 31611678
Adv Drug Deliv Rev. 2015 Apr;84:159-71
pubmed: 24993611
EMBO J. 2011 Nov 08;30(23):4701-11
pubmed: 22068051
Theranostics. 2020 Jan 16;10(5):2342-2357
pubmed: 32104507
Rheumatology (Oxford). 2008 Jun;47(6):809-14
pubmed: 18397957
Spine (Phila Pa 1976). 2011 May 1;36(10):770-7
pubmed: 20683388
Cell Death Dis. 2018 Jan 22;9(2):67
pubmed: 29358575
Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):12028-12033
pubmed: 30373845

Auteurs

Qiangqiang Zheng (Q)

Spine lab, Department of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Haotian Shen (H)

Spine lab, Department of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Zongrui Tong (Z)

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.

Linxiang Cheng (L)

Spine lab, Department of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Yuzi Xu (Y)

Department of Oral Implantology and Prosthodontics, The Affiliated Stomatology Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, P.R. China.

Zhiyun Feng (Z)

Spine lab, Department of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Shiyao Liao (S)

Department of Orthopedic Surgery, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou 310003, China.

Xiaojian Hu (X)

Spine lab, Department of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Zongyou Pan (Z)

Spine lab, Department of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, And Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Zhengwei Mao (Z)

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.

Yue Wang (Y)

Spine lab, Department of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Eucaryotes › Animaux › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Technique d'immunofluorescence › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Monokines › Interleukine-1 › Interleukine-1 bêta › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies osseuses › Maladies du rachis › Dégénérescence de disque intervertébral › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Tissus › Tissu conjonctif › Cartilage › Fibrocartilage › Disque intervertébral › Nucleus pulposus › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Fragments peptidiques › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Cellules THP-1 › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines à motif tripartite › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › A thermosensitive, reactive oxygen...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Microtomographie aux rayons X › A thermosensitive, reactive oxygen...