Expansion of murine and human olfactory epithelium/mucosa colonies and generation of mature olfactory sensory neurons under chemically defined conditions.
Alanine
/ analogs & derivatives
Animals
Azepines
/ pharmacology
Cell Differentiation
Cell Proliferation
Female
Humans
Male
Mice
Neurogenesis
Olfactory Mucosa
/ cytology
Olfactory Receptor Neurons
/ cytology
Pyridines
/ pharmacology
Pyrimidines
/ pharmacology
Receptors, G-Protein-Coupled
/ genetics
Stem Cells
/ cytology
Lgr5
Olfactory epithelium/mucosa
colony
olfactory sensory neurons
three-dimensional culture
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2021
2021
Historique:
received:
07
04
2020
accepted:
29
09
2020
entrez:
4
1
2021
pubmed:
5
1
2021
medline:
5
8
2021
Statut:
epublish
Résumé
Olfactory dysfunctions, including hyposmia and anosmia, affect ~100 million people around the world and the underlying causes are not fully understood. Degeneration of olfactory sensory neurons and incapacity of globose basal cells to generate olfactory sensory neurons are found in elder people and patients with smell disorders. Thus, olfactory stem cell may function as a promising tool to replace inactivated globose basal cells and to generate sensory neurons.
Identifiants
pubmed: 33391499
doi: 10.7150/thno.46750
pii: thnov11p0684
pmc: PMC7738855
doi:
Substances chimiques
Azepines
0
Chir 99021
0
LGR5 protein, human
0
N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide
0
Pyridines
0
Pyrimidines
0
Receptors, G-Protein-Coupled
0
Alanine
OF5P57N2ZX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
684-699Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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