Phosphoproteomics identify arachidonic-acid-regulated signal transduction pathways modulating macrophage functions with implications for ovarian cancer.
Arachidonic Acid
/ pharmacology
Calcium
/ metabolism
Extracellular Vesicles
/ drug effects
Female
Group II Phospholipases A2
/ metabolism
Humans
Macrophages
/ drug effects
Neoplasm Recurrence, Local
/ drug therapy
Ovarian Neoplasms
/ drug therapy
Phosphorylation
/ drug effects
Reactive Oxygen Species
/ metabolism
Signal Transduction
/ drug effects
Transcription, Genetic
/ drug effects
Tumor Microenvironment
/ drug effects
arachidonic acid
macropinocytosis
ovarian cancer
phosphoproteomics
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
08
2020
accepted:
28
09
2020
entrez:
4
1
2021
pubmed:
5
1
2021
medline:
23
7
2021
Statut:
epublish
Résumé
Arachidonic acid (AA) is a polyunsaturated fatty acid present at high concentrations in the ovarian cancer (OC) microenvironment and associated with a poor clinical outcome. In the present study, we have unraveled a potential link between AA and macrophage functions.
Identifiants
pubmed: 33391540
doi: 10.7150/thno.52442
pii: thnov11p1377
pmc: PMC7738879
doi:
Substances chimiques
Reactive Oxygen Species
0
Arachidonic Acid
27YG812J1I
Group II Phospholipases A2
EC 3.1.1.4
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1377-1395Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
Références
J Biol Chem. 2017 Feb 24;292(8):3099-3111
pubmed: 28053086
Pathol Int. 2009 May;59(5):300-5
pubmed: 19432671
Nat Med. 2015 Aug;21(8):938-945
pubmed: 26193342
Endocr Relat Cancer. 2012 Apr 10;19(2):197-208
pubmed: 22277193
Cell. 2020 Aug 20;182(4):1044-1061.e18
pubmed: 32795414
Front Immunol. 2018 Oct 02;9:2286
pubmed: 30333835
J Thromb Haemost. 2020 Nov;18(11):3002-3012
pubmed: 32692911
Adv Biol Regul. 2013 Jan;53(1):135-44
pubmed: 23031789
Biochem Biophys Res Commun. 2005 Feb 4;327(1):136-42
pubmed: 15629441
Genome Biol. 2016 May 23;17(1):108
pubmed: 27215396
Curr Drug Targets. 2016;17(16):1940-1962
pubmed: 26212262
Cell. 2010 Apr 2;141(1):39-51
pubmed: 20371344
Biochemistry. 2003 Apr 22;42(15):4485-91
pubmed: 12693944
Methods Mol Biol. 2016;1355:161-77
pubmed: 26584925
FEBS Lett. 2002 Oct 30;531(1):2-6
pubmed: 12401193
Biochemistry. 2018 Feb 6;57(5):772-780
pubmed: 29261301
Mol Pharmacol. 2008 Nov;74(5):1269-77
pubmed: 18701617
J Clin Invest. 2015 Nov 03;125(12):4407-20
pubmed: 26529257
J Immunol. 1990 Jan 15;144(2):671-7
pubmed: 2295805
Lipids Health Dis. 2013 Jul 13;12:101
pubmed: 23849180
Mol Cell Biol. 2013 Nov;33(21):4152-65
pubmed: 23979601
Oncol Lett. 2018 Apr;15(4):5236-5242
pubmed: 29541252
Oncotarget. 2016 Nov 15;7(46):75339-75352
pubmed: 27659538
Haematologica. 2020 Jan 23;:
pubmed: 31974204
Crit Rev Immunol. 2017;37(2-6):127-195
pubmed: 29773019
Braz J Med Biol Res. 2003 Nov;36(11):1549-60
pubmed: 14576910
Blood. 1996 Nov 15;88(10):3792-800
pubmed: 8916943
Chem Biol Interact. 1996 Mar 25;100(2):141-53
pubmed: 8646787
J Biol Chem. 1996 Sep 6;271(36):21720-5
pubmed: 8702966
Trends Mol Med. 2016 Sep;22(9):741-743
pubmed: 27474394
Cell. 2019 Apr 4;177(2):428-445.e18
pubmed: 30951670
J Biol Chem. 2014 Sep 5;289(36):24874-84
pubmed: 25056956
Mol Cell Proteomics. 2019 Aug;18(8):1700-1702
pubmed: 31097673
J Lipid Res. 2012 Nov;53(11):2343-54
pubmed: 22949356
Nat Biotechnol. 2008 Dec;26(12):1367-72
pubmed: 19029910
J Ovarian Res. 2014 Jan 25;7:14
pubmed: 24460816
Lipids. 1979 Feb;14(2):181-93
pubmed: 106197
Prostaglandins Leukot Essent Fatty Acids. 2017 Feb;117:1-10
pubmed: 28237082
Cell. 2006 Jan 27;124(2):263-6
pubmed: 16439202
Oncotarget. 2015 May 20;6(14):11725-34
pubmed: 25961153
Cell Signal. 1995 Mar;7(3):171-84
pubmed: 7662506
FEBS Lett. 1987 Mar 23;213(2):316-8
pubmed: 3556584
J Proteome Res. 2011 Apr 1;10(4):1794-805
pubmed: 21254760
Science. 2020 Feb 7;367(6478):
pubmed: 32029601
J Biol Chem. 2003 Sep 5;278(36):33753-62
pubmed: 12824193
J Clin Invest. 2019 Jun 17;129(7):2775-2791
pubmed: 31205027
J Biol Chem. 1993 Nov 15;268(32):24210-4
pubmed: 8226968
J Neurosci. 1993 Oct;13(10):4361-71
pubmed: 8410192
Nat Rev Mol Cell Biol. 2008 Feb;9(2):162-76
pubmed: 18216772
J Pharm Pharmacol. 2000 May;52(5):539-46
pubmed: 10864142
Nat Rev Mol Cell Biol. 2018 Apr;19(4):213-228
pubmed: 29339798
Histol Histopathol. 2014 Mar;29(3):313-21
pubmed: 24194373
Oncotarget. 2015 May 30;6(15):13416-33
pubmed: 25968567
Int J Mol Sci. 2019 Feb 15;20(4):
pubmed: 30781344
J Cell Sci. 2011 Mar 1;124(Pt 5):679-83
pubmed: 21321325
Clin Pharmacokinet. 2020 Sep;59(9):1109-1117
pubmed: 32333325
Nucleic Acids Res. 2020 Jan 8;48(D1):D682-D688
pubmed: 31691826
J Mol Med (Berl). 2020 Mar;98(3):335-348
pubmed: 32060587
Cancer Lett. 2015 Oct 10;367(1):26-33
pubmed: 26189430
Biochemistry (Mosc). 2014 May;79(5):435-9
pubmed: 24954594
Free Radic Biol Med. 2012 Oct 1;53(7):1522-30
pubmed: 22902630
Int J Mol Sci. 2020 Mar 11;21(6):
pubmed: 32168915
EMBO Rep. 2004 Feb;5(2):161-6
pubmed: 14749717
Sci Rep. 2017 Jun 14;7(1):3521
pubmed: 28615717
Nucleic Acids Res. 2019 Jan 8;47(D1):D442-D450
pubmed: 30395289
Int J Mol Sci. 2013 Mar 28;14(4):7089-108
pubmed: 23538840
Biochem J. 2010 Aug 1;429(3):403-17
pubmed: 20626350
Front Oncol. 2020 Feb 25;10:188
pubmed: 32161718
Br J Pharmacol. 2008 Sep;155(1):4-16
pubmed: 18552881
Proc Natl Acad Sci U S A. 2012 May 29;109(22):8517-22
pubmed: 22586114
Exp Mol Med. 2018 Sep 21;50(9):127
pubmed: 30242145
FASEB J. 1993 Feb 1;7(2):328-38
pubmed: 7680013
Mol Biol Cell. 2009 Aug;20(16):3628-37
pubmed: 19570911
PLoS One. 2015 Apr 13;10(4):e0125145
pubmed: 25867515
Front Oncol. 2019 Nov 01;9:1150
pubmed: 31737572
Front Oncol. 2017 Feb 22;7:24
pubmed: 28275576
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
Trends Pharmacol Sci. 2017 Sep;38(9):809-821
pubmed: 28734639
Front Cell Dev Biol. 2020 Apr 03;8:222
pubmed: 32309283
Theranostics. 2020 May 17;10(15):6581-6598
pubmed: 32550891
J Biol Chem. 2001 Jul 6;276(27):24743-50
pubmed: 11328812
J Cell Sci. 1998 Apr;111 ( Pt 7):941-50
pubmed: 9490638
Biochim Biophys Acta. 2013 Jan;1831(1):74-85
pubmed: 22954454
Br J Pharmacol. 2013 Apr;168(8):1820-34
pubmed: 23186227
Anal Biochem. 1992 Jan;200(1):199-204
pubmed: 1595896
J Extracell Vesicles. 2020 Feb 3;9(1):1713526
pubmed: 32128070
J Clin Invest. 2012 Mar;122(3):787-95
pubmed: 22378047
Theranostics. 2019 Aug 22;9(22):6601-6617
pubmed: 31588238
Biochem Biophys Res Commun. 1997 Aug 18;237(2):413-8
pubmed: 9268725
Nat Rev Cancer. 2003 Aug;3(8):582-91
pubmed: 12894246
ACS Med Chem Lett. 2017 Feb 08;8(3):316-320
pubmed: 28337323
Cell Commun Signal. 2009 Apr 24;7:9
pubmed: 19389260
Curr Drug Targets. 2014 Apr;15(4):423-31
pubmed: 24138636
J Extracell Vesicles. 2020 Jan 7;9(1):1710020
pubmed: 32002172
Front Oncol. 2013 Sep 25;3:256
pubmed: 24093089
J Immunol. 2012 Jan 1;188(1):21-8
pubmed: 22187483
J Clin Invest. 1998 Jul 1;102(1):165-75
pubmed: 9649570
Int J Cancer. 2014 Jan 1;134(1):32-42
pubmed: 23784932
Mol Oncol. 2019 Feb;13(2):185-201
pubmed: 30353652
Blood. 2011 Jan 27;117(4):e39-48
pubmed: 21041717
J Cell Sci. 1997 Jul;110 ( Pt 14):1625-34
pubmed: 9247196
Gene. 2018 Jul 20;664:152-167
pubmed: 29679756
J Immunol. 1991 Jul 1;147(1):231-6
pubmed: 1646842
Front Immunol. 2019 Jul 31;10:1799
pubmed: 31417566
J Exp Med. 1989 Nov 1;170(5):1635-48
pubmed: 2681516
Nat Rev Immunol. 2012 Mar 22;12(4):253-68
pubmed: 22437938