Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures.
SARS-CoV-2
COVID-19
Caucasian patient
angiotensin-converting enzyme 2
electron microscopy
kidney disease
tubular proteinuria
Journal
Clinical kidney journal
ISSN: 2048-8505
Titre abrégé: Clin Kidney J
Pays: England
ID NLM: 101579321
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
15
09
2020
accepted:
28
09
2020
entrez:
4
1
2021
pubmed:
5
1
2021
medline:
5
1
2021
Statut:
epublish
Résumé
The objectives were to characterize Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) in patients with acute kidney injury (AKI). Kidney biopsy samples in two Caucasian patients and one African with COVID-19 AKI were investigated. All patients had a high-level non-selective glomerular proteinuria. SARS-CoV-2 samples by real-time polymerase chain reaction (RT- PCR) assay were all-negative, as well as for virus particles in the kidney by electron microscopy. The three patients and patients with other AKI did not differ significantly with regard to angiotensin-converting enzyme 2 and transmembrane protease serine 2 kidney staining. The kidney damage particularly in Caucasians in COVID-19 seems to be an AKI, possibly by the systemic inflammatory response.
Sections du résumé
BACKGROUND
BACKGROUND
The objectives were to characterize Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) in patients with acute kidney injury (AKI).
METHODS
METHODS
Kidney biopsy samples in two Caucasian patients and one African with COVID-19 AKI were investigated.
RESULTS
RESULTS
All patients had a high-level non-selective glomerular proteinuria. SARS-CoV-2 samples by real-time polymerase chain reaction (RT- PCR) assay were all-negative, as well as for virus particles in the kidney by electron microscopy. The three patients and patients with other AKI did not differ significantly with regard to angiotensin-converting enzyme 2 and transmembrane protease serine 2 kidney staining.
CONCLUSIONS
CONCLUSIONS
The kidney damage particularly in Caucasians in COVID-19 seems to be an AKI, possibly by the systemic inflammatory response.
Identifiants
pubmed: 33391755
doi: 10.1093/ckj/sfaa209
pii: sfaa209
pmc: PMC7769537
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1101-1104Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA.
Références
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