Epigenome-wide association study (EWAS) for potential transgenerational disease epigenetic biomarkers in sperm following ancestral exposure to the pesticide methoxychlor.
DNA methylation
EWAS
biomarker
disease
epimutation
kidney
obesity
prostate
transgenerational
Journal
Environmental epigenetics
ISSN: 2058-5888
Titre abrégé: Environ Epigenet
Pays: England
ID NLM: 101675941
Informations de publication
Date de publication:
2020
2020
Historique:
received:
02
06
2020
revised:
22
10
2020
accepted:
23
10
2020
entrez:
4
1
2021
pubmed:
5
1
2021
medline:
5
1
2021
Statut:
epublish
Résumé
Environmental exposures such as chemical toxicants can alter gene expression and disease susceptibility through epigenetic processes. Epigenetic changes can be passed to future generations through germ cells through epigenetic transgenerational inheritance of increased disease susceptibility. The current study used an epigenome-wide association study (EWAS) to investigate whether specific transgenerational epigenetic signatures of differential DNA methylation regions (DMRs) exist that are associated with particular disease states in the F3 generation great-grand offspring of F0 generation rats exposed during gestation to the agricultural pesticide methoxychlor. The transgenerational epigenetic profiles of sperm from F3 generation methoxychlor lineage rats that have only one disease state were compared to those that have no disease. Observations identify disease specific patterns of DMRs for these transgenerational rats that can potentially serve as epigenetic biomarkers for prostate disease, kidney disease, obesity, and the presence of multiple diseases. The chromosomal locations, genomic features, and gene associations of the DMRs are characterized. Disease specific DMR sets contained DMR-associated genes that have previously been shown to be associated with that specific disease. Future epigenetic biomarkers could potentially be developed and validated for humans as a disease susceptibility diagnostic tool to facilitate preventative medicine and management of disease.
Identifiants
pubmed: 33391823
doi: 10.1093/eep/dvaa020
pii: dvaa020
pmc: PMC7757123
doi:
Types de publication
Journal Article
Langues
eng
Pagination
dvaa020Informations de copyright
© The Author(s) 2020. Published by Oxford University Press.
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