A methodology for examining the association between plasma volume and micronutrient biomarker mass and concentration in healthy eumenorrheic women.

Indocyanine green Nutritional biomarker Hydration Menstrual cycle Methodology for micronutrient Ovarian cycle Plasma volume

Journal

PeerJ

ISSN: 2167-8359

Titre abrégé: PeerJ

Pays: United States

ID NLM: 101603425

Informations de publication

Date de publication:
2020

Historique:

received: 26 03 2020

accepted: 19 11 2020

entrez: 4 1 2021

pubmed: 5 1 2021

medline: 5 1 2021

Statut: epublish

Résumé

Accurate estimation and interpretation of nutritional biomarker concentrations are important in nutritional research, clinical care, and public health surveillance. Plasma volume (PV) may affect the interpretation of plasma biomarkers but is rarely measured. We aimed to examine the association between plasma volume (PV) and micronutrient biomarker concentrations and mass as part of pilot work to develop methods. Nine healthy women with regular menstrual cycles provided fasting blood samples to measure micronutrient biomarkers. Indocyanine green was injected, and five timed blood draws were taken from 2 to 5 min to measure PV. Visits were scheduled around menstrual cycle day 2. Retinol, 25-hydroxyvitamin D, riboflavin, alpha-tocopherol, zinc, copper, magnesium, manganese, cobalt, iron, and ferritin concentrations were measured in serum. Total circulating micronutrient biomarker mass was calculated from PV and concentration. The mean PV was 2067 ± 470 mL. PV correlated positively with concentration of iron ( Though there appear to be some association between micronutrient biomarker mass and plasma volume, we are unable to draw a firm conclusion about any relationship from these results because of the small sample size. We consider these findings as a preliminary analysis to establish methods for future studies.

Sections du résumé

BACKGROUND BACKGROUND

METHODS METHODS

Nine healthy women with regular menstrual cycles provided fasting blood samples to measure micronutrient biomarkers. Indocyanine green was injected, and five timed blood draws were taken from 2 to 5 min to measure PV. Visits were scheduled around menstrual cycle day 2. Retinol, 25-hydroxyvitamin D, riboflavin, alpha-tocopherol, zinc, copper, magnesium, manganese, cobalt, iron, and ferritin concentrations were measured in serum. Total circulating micronutrient biomarker mass was calculated from PV and concentration.

RESULTS RESULTS

The mean PV was 2067 ± 470 mL. PV correlated positively with concentration of iron (

CONCLUSION CONCLUSIONS

Though there appear to be some association between micronutrient biomarker mass and plasma volume, we are unable to draw a firm conclusion about any relationship from these results because of the small sample size. We consider these findings as a preliminary analysis to establish methods for future studies.

Identifiants

DOI: 10.7717/peerj.10535 PMID: 33391876 PMC: PMC7759127

pubmed: 33391876

doi: 10.7717/peerj.10535

pii: 10535

pmc: PMC7759127

doi:

Banques de données

figshare

['10.6084/m9.figshare.13249574.v1']

Types de publication

Journal Article

Langues

eng

Pagination

e10535

Subventions

Organisme : NCATS NIH HHS

ID : UL1 TR002014

Pays : United States

Informations de copyright

Déclaration de conflit d'intérêts

The authors declare there are no competing interests.

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