Parametric estimation of reference signal intensity in the quantification of amyloid-beta deposition: an
Alzheimer’s disease (AD)
Amyloid-beta (Aβ)
florbetapir positron emission tomography
parametric estimation of reference signal intensity (PERSI)
quantification
standardized uptake value ratio (SUVR)
Journal
Quantitative imaging in medicine and surgery
ISSN: 2223-4292
Titre abrégé: Quant Imaging Med Surg
Pays: China
ID NLM: 101577942
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
entrez:
4
1
2021
pubmed:
5
1
2021
medline:
5
1
2021
Statut:
ppublish
Résumé
Positron emission tomography (PET) with the radiotracer florbetapir ( We enrolled 479 people with The SUVRs derived from PERSI-WM showed significantly higher trace retention in the frontal, parietal, temporal, and occipital lobes, as well as in the anterior cingulate, posterior cingulate, precuneus, and global cortex in the AD Aβ-positive (+) group (mean: +43.3%±5.4%, P<0.01) and MCI Aβ+ group (mean: +29.6%±5.3%, P<0.01). For the global cortex, PERSI-WM had the greatest Cohen's d effect size compared with the HC Aβ-negative (-) group (AD Aβ+ and MCI Aβ+: 3.02, AD Aβ+: 3.56, MCI Aβ+: 2.34), and the highest area under the curve (AUC) between the HC Aβ- and AD Aβ+ groups (AUC: 0.983, 95% confidence interval: 0.978-0.998). PERSI-WM could mitigate the influence of PVE and improve the semi-quantification of
Sections du résumé
BACKGROUND
BACKGROUND
Positron emission tomography (PET) with the radiotracer florbetapir (
METHODS
METHODS
We enrolled 479 people with
RESULTS
RESULTS
The SUVRs derived from PERSI-WM showed significantly higher trace retention in the frontal, parietal, temporal, and occipital lobes, as well as in the anterior cingulate, posterior cingulate, precuneus, and global cortex in the AD Aβ-positive (+) group (mean: +43.3%±5.4%, P<0.01) and MCI Aβ+ group (mean: +29.6%±5.3%, P<0.01). For the global cortex, PERSI-WM had the greatest Cohen's d effect size compared with the HC Aβ-negative (-) group (AD Aβ+ and MCI Aβ+: 3.02, AD Aβ+: 3.56, MCI Aβ+: 2.34), and the highest area under the curve (AUC) between the HC Aβ- and AD Aβ+ groups (AUC: 0.983, 95% confidence interval: 0.978-0.998).
CONCLUSIONS
CONCLUSIONS
PERSI-WM could mitigate the influence of PVE and improve the semi-quantification of
Identifiants
pubmed: 33392026
doi: 10.21037/qims-20-110
pii: qims-11-01-249
pmc: PMC7719939
doi:
Types de publication
Journal Article
Langues
eng
Pagination
249-263Subventions
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Informations de copyright
2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/qims-20-110). The authors have no conflicts of interest to declare.
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