Role of Chronic Alcoholism Causing Cancer in Omnivores and Vegetarians through Epigenetic Modifications.
cancer epigenetic mechanisms
chronic alcohol use
dietary deficiencies
epigenetic modifications
omnivores and vegetarians
Journal
Global medical genetics
ISSN: 2699-9404
Titre abrégé: Glob Med Genet
Pays: Germany
ID NLM: 101769583
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
entrez:
4
1
2021
pubmed:
5
1
2021
medline:
5
1
2021
Statut:
ppublish
Résumé
One of the significant consequences of alcohol consumption is cancer formation via several contributing factors such as action of alcohol metabolites, vitamin deficiencies, and oxidative stress. All these factors have been shown to cause epigenetic modifications via DNA hypomethylation, thus forming a basis for cancer development. Several published reviews and studies were systematically reviewed. Omnivores and vegetarians differ in terms of nutritional intake and deficiencies. As folate deficiency was found to be common among the omnivores, chronic alcoholism could possibly cause damage and eventually cancer in an omnivorous individual via DNA hypomethylation due to folate deficiency. Furthermore, as niacin was found to be deficient among vegetarians, damage in vegetarian chronic alcoholics could be due to increased NADH/NAD
Identifiants
pubmed: 33392610
doi: 10.1055/s-0040-1721814
pii: 2000017
pmc: PMC7772008
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
80-86Informations de copyright
The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ).
Déclaration de conflit d'intérêts
Conflict of Interest None declared.
Références
Alcohol Clin Exp Res. 2007 Jul;31(7):1231-9
pubmed: 17577393
Nat Rev Cancer. 2007 Aug;7(8):599-612
pubmed: 17646865
Exp Mol Pathol. 2011 Oct;91(2):540-7
pubmed: 21708146
Amino Acids. 2008 Feb;34(2):187-93
pubmed: 17334902
Alcohol Res. 2013;35(1):6-16
pubmed: 24313160
Eur J Nutr. 2017 Feb;56(1):283-293
pubmed: 26502280
J Lab Clin Med. 1967 Jan;69(1):116-31
pubmed: 6018064
Cancer Cell. 2014 Dec 8;26(6):826-839
pubmed: 25453901
Alcohol Clin Exp Res. 2011 Nov;35(11):1960-5
pubmed: 22044287
J Lab Clin Med. 1983 Apr;101(4):623-8
pubmed: 6682133
Hepatology. 2010 Mar;51(3):932-41
pubmed: 19957376
Hum Mol Genet. 2005 Apr 15;14 Spec No 1:R139-47
pubmed: 15809266
Nutr Cancer. 2003;46(2):110-8
pubmed: 14690785
Exp Mol Pathol. 2010 Jun;88(3):376-9
pubmed: 20206621
Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1261-4
pubmed: 8108398
Alcohol Clin Exp Res. 2007 Nov;31(11):1934-43
pubmed: 17850216
Alcohol Res. 2013;35(1):57-67
pubmed: 24313165
Am J Clin Nutr. 1983 Jul;38(1):64-70
pubmed: 6407299
Cancer Res. 2003 Jun 15;63(12):3133-7
pubmed: 12810640
Alcohol Clin Exp Res. 2009 Apr;33(4):684-92
pubmed: 19170665
J Natl Cancer Inst. 2005 Jun 15;97(12):906-16
pubmed: 15956652
World J Gastroenterol. 2010 Feb 21;16(7):897-903
pubmed: 20143470
Am J Epidemiol. 2002 Feb 15;155(4):323-31
pubmed: 11836196
Exp Mol Pathol. 2007 Apr;82(2):197-202
pubmed: 17208223
J Nutr. 1989 Oct;119(10):1490-7
pubmed: 2585139
Biol Signals Recept. 2001 May-Aug;10(3-4):271-82
pubmed: 11351133
Alcohol Clin Exp Res. 1991 Jun;15(3):395-8
pubmed: 1877725
Biochem Cell Biol. 1987 Mar;65(3):230-3
pubmed: 3580171
Semin Liver Dis. 2004 Aug;24(3):289-304
pubmed: 15349806
Gastroenterology. 2004 Nov;127(5 Suppl 1):S87-96
pubmed: 15508108
J Clin Invest. 2007 Sep;117(9):2713-22
pubmed: 17717605
Lancet Oncol. 2007 Apr;8(4):292-3
pubmed: 17431955
Int J Biochem Cell Biol. 2000 Apr;32(4):391-5
pubmed: 10762064
PLoS One. 2010 Mar 17;5(3):e9749
pubmed: 20305825
Int J Cancer. 2005 Feb 20;113(5):829-34
pubmed: 15499619
PLoS Genet. 2010 Jul 29;6(7):e1001043
pubmed: 20686660
Alcohol Alcohol. 2012 May-Jun;47(3):204-12
pubmed: 22459019
Biochem Pharmacol. 2005 Dec 5;70(12):1883-90
pubmed: 16253211
PLoS One. 2011;6(6):e20456
pubmed: 21674008
Mol Cell Biochem. 2012 Apr;363(1-2):157-66
pubmed: 22147198
J Cell Physiol. 2011 Mar;226(3):579-87
pubmed: 21069807
Am J Clin Nutr. 2012 Feb;95(2):405-12
pubmed: 22218157
Alcohol Clin Exp Res. 2002 Mar;26(3):347-51
pubmed: 11923587
Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1509-14
pubmed: 15342453
Nutr Cancer. 2011;63(7):983-90
pubmed: 21864055
Biosci Biotechnol Biochem. 2005 Mar;69(3):653-8
pubmed: 15785001
J Natl Cancer Inst. 1995 Feb 15;87(4):265-73
pubmed: 7707417
Int J Cancer. 2006 Aug 15;119(4):884-7
pubmed: 16557583
Alcohol Clin Exp Res. 2001 Mar;25(3):415-20
pubmed: 11290853
Exp Mol Pathol. 2006 Dec;81(3):191-201
pubmed: 17034788
J Neural Transm (Vienna). 2006 Sep;113(9):1299-304
pubmed: 16463117
N Engl J Med. 1971 Sep 23;285(13):701-6
pubmed: 5571128
Lancet Oncol. 2015 Dec;16(16):1599-600
pubmed: 26514947
Alcohol Res. 2013;35(1):25-35
pubmed: 24313162
J Hepatol. 2007 Feb;46(2):314-21
pubmed: 17156888
Exp Mol Pathol. 2012 Apr;92(2):191-3
pubmed: 22273483
Carcinogenesis. 1984 Jul;5(7):901-6
pubmed: 6145526
Mol Nutr Food Res. 2013 Apr;57(4):596-606
pubmed: 23136133
Biochem Biophys Res Commun. 2006 Aug 18;347(1):89-99
pubmed: 16814255