Regulation and dysregulation of spatial chromatin structure in the central nervous system.
Brain
Central nervous system
Chromatin
Disease
Genome
Journal
Anatomical science international
ISSN: 1447-073X
Titre abrégé: Anat Sci Int
Pays: Japan
ID NLM: 101154140
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
13
07
2020
accepted:
27
08
2020
pubmed:
5
1
2021
medline:
13
4
2021
entrez:
4
1
2021
Statut:
ppublish
Résumé
Chromatin exists as a non-linear, "three-dimensional" structure in the nuclear space. The dynamic alteration of the chromatin structure leads to transcriptional changes during the formation of the neuronal network. Several studies providing evidence for the link between the dysregulation of spatial chromatin architecture and developmental disorders have accumulated. Therefore, we studied and reviewed the regulation and dysregulation of 3D genome organization in the central nervous system, with a special focus on the cohesin complex that is crucial for the formation of the chromatin loop structure. This review summarizes the function and mechanisms of spatial chromatin architecture during the development of the central nervous system. We discuss the link between the disturbances in the 3D chromatin structure and the diseases of the central nervous system. Finally, we discuss how the knowledge of 3D genome organization may lead to further advances in diagnosis and therapy for the diseases of the central nervous system.
Identifiants
pubmed: 33392926
doi: 10.1007/s12565-020-00567-7
pii: 10.1007/s12565-020-00567-7
doi:
Substances chimiques
Chromatin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
179-186Subventions
Organisme : Japan Society for the Promotion of Science
ID : 19K07266
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