Interleukin-6 neutralization ameliorates symptoms in prematurely aged mice.
accelerated aging
ageing
anti-aging
cellular senescence
cytokines
inflammation
laminopathies
nuclear lamina
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
21
08
2020
revised:
23
10
2020
accepted:
14
11
2020
pubmed:
5
1
2021
medline:
3
9
2021
entrez:
4
1
2021
Statut:
ppublish
Résumé
Hutchinson-Gilford progeria syndrome (HGPS) causes premature aging in children, with adipose tissue, skin and bone deterioration, and cardiovascular impairment. In HGPS cells and mouse models, high levels of interleukin-6, an inflammatory cytokine linked to aging processes, have been detected. Here, we show that inhibition of interleukin-6 activity by tocilizumab, a neutralizing antibody raised against interleukin-6 receptors, counteracts progeroid features in both HGPS fibroblasts and Lmna
Identifiants
pubmed: 33393189
doi: 10.1111/acel.13285
pmc: PMC7811841
doi:
Substances chimiques
Interleukin-6
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13285Informations de copyright
© 2021 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
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