Multiple potential roles of thymosin β4 in the growth and development of hair follicles.
development
growth
hair follicle
thymosin β4
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
17
08
2020
revised:
09
12
2020
accepted:
15
12
2020
pubmed:
5
1
2021
medline:
23
9
2021
entrez:
4
1
2021
Statut:
ppublish
Résumé
The hair follicle (HF) is an important mini-organ of the skin, composed of many types of cells. Dermal papilla cells are important signalling components that guide the proliferation, upward migration and differentiation of HF stem cell progenitor cells to form other types of HF cells. Thymosin β4 (Tβ4), a major actin-sequestering protein, is involved in various cellular responses and has recently been shown to play key roles in HF growth and development. Endogenous Tβ4 can activate the mouse HF cycle transition and affect HF growth and development by promoting the migration and differentiation of HF stem cells and their progeny. In addition, exogenous Tβ4 increases the rate of hair growth in mice and promotes cashmere production by increasing the number of secondary HFs (hair follicles) in cashmere goats. However, the molecular mechanisms through which Tβ4 promotes HF growth and development have rarely been reported. Herein, we review the functions and mechanisms of Tβ4 in HF growth and development and describe the endogenous and exogenous actions of Tβ4 in HFs to provide insights into the roles of Tβ4 in HF growth and development.
Identifiants
pubmed: 33393222
doi: 10.1111/jcmm.16241
pmc: PMC7875905
doi:
Substances chimiques
thymosin beta(4)
549LM7U24W
Thymosin
61512-21-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1350-1358Subventions
Organisme : the Science and Technology Innovation Guided Project in Inner Mongolia Autonomous Region
ID : KCBJ2018003
Informations de copyright
© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
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