Rapid adaptation to malaria facilitated by admixture in the human population of Cabo Verde.
admixture
evolutionary biology
genetic ancestry
genetics
genomics
human
natural selection
population genetics
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
04 01 2021
04 01 2021
Historique:
received:
16
09
2020
accepted:
04
01
2021
pubmed:
5
1
2021
medline:
4
9
2021
entrez:
4
1
2021
Statut:
epublish
Résumé
Humans have undergone large migrations over the past hundreds to thousands of years, exposing ourselves to new environments and selective pressures. Yet, evidence of ongoing or recent selection in humans is difficult to detect. Many of these migrations also resulted in gene flow between previously separated populations. These recently admixed populations provide unique opportunities to study rapid evolution in humans. Developing methods based on distributions of local ancestry, we demonstrate that this sort of genetic exchange has facilitated detectable adaptation to a malaria parasite in the admixed population of Cabo Verde within the last ~20 generations. We estimate that the selection coefficient is approximately 0.08, one of the highest inferred in humans. Notably, we show that this strong selection at a single locus has likely affected patterns of ancestry genome-wide, potentially biasing demographic inference. Our study provides evidence of adaptation in a human population on historical timescales.
Identifiants
pubmed: 33393457
doi: 10.7554/eLife.63177
pii: 63177
pmc: PMC7815310
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : F32 GM139313
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM133481
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM136627
Pays : United States
Informations de copyright
© 2021, Hamid et al.
Déclaration de conflit d'intérêts
IH, KK, SB, AG No competing interests declared
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