Treatment Timing, EEG, Neuroimaging, and Outcomes After Acute Necrotizing Encephalopathy in Children.
EEG
MRI
genetics
neuroimmunology
seizures
Journal
Journal of child neurology
ISSN: 1708-8283
Titre abrégé: J Child Neurol
Pays: United States
ID NLM: 8606714
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
pubmed:
5
1
2021
medline:
14
1
2022
entrez:
4
1
2021
Statut:
ppublish
Résumé
Acute necrotizing encephalopathy (ANE) is a rare condition associated with rapid progression to coma and high incidence of morbidity and mortality. Clinical, electroencephalographic (EEG), and brain magnetic resonance imaging (MRI) characteristics and immunomodulatory therapy timing were retrospectively analyzed in children with ANE. ANE severity scores (ANE-SS) and MRI scores were also assessed. The associations of patient characteristics with 6-month modified Rankin scale (mRS) and length of hospitalization were determined using either univariate linear regression or one-way analysis of variance. 7 children were retrospectively evaluated. Normal EEG sleep spindles ( Early immunomodulatory therapy and normal sleep spindles are associated with better functional outcome in children with ANE.
Sections du résumé
BACKGROUND
Acute necrotizing encephalopathy (ANE) is a rare condition associated with rapid progression to coma and high incidence of morbidity and mortality.
METHODS
Clinical, electroencephalographic (EEG), and brain magnetic resonance imaging (MRI) characteristics and immunomodulatory therapy timing were retrospectively analyzed in children with ANE. ANE severity scores (ANE-SS) and MRI scores were also assessed. The associations of patient characteristics with 6-month modified Rankin scale (mRS) and length of hospitalization were determined using either univariate linear regression or one-way analysis of variance.
RESULTS
7 children were retrospectively evaluated. Normal EEG sleep spindles (
CONCLUSION
Early immunomodulatory therapy and normal sleep spindles are associated with better functional outcome in children with ANE.
Identifiants
pubmed: 33393838
doi: 10.1177/0883073820984063
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM