Treatment of knee osteoarthritis by intra-articular injection of concentrated autologous adipose tissue: a twenty four month follow-up study.
Arthritis
Concentrated autologous adipose tissue
Knee
Mesenchymal stem cells
Journal
International orthopaedics
ISSN: 1432-5195
Titre abrégé: Int Orthop
Pays: Germany
ID NLM: 7705431
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
17
12
2020
accepted:
18
12
2020
pubmed:
5
1
2021
medline:
24
4
2021
entrez:
4
1
2021
Statut:
ppublish
Résumé
To evaluate the safety and efficacy of autologous concentrated adipose tissue for the treatment of knee OA. Eighty-seven patients with knee arthritis from grade 1 to 3, according to Kellgren-Lawrence scale, have been treated with knee arthroscopy and successive intra-articular injection of concentrated adipose tissue. The efficacy of the treatment has been evaluated by the Knee Society Score, Lysholm Score, Forgotten Joint Score, Knee Injury and Osteoarthritis Outcome Score and Noise Reporting Scale. A total of 78/87 patients concluded the study. Overall, the patients were satisfied with the intervention and a significant reduction of the pain was observed in 67 patients, while the others did not report any change in pain severity or worsening. A statistically significant improvement was observed in the considered orthopaedic index, and no major adverse effects were described. The first week after the intervention, most patients reported knee swelling. Five patients failed because they underwent knee replacement surgery between five and nine months from treatment. In patients with knee OA, a single intra-articular injection of autologous adipose tissue reduced knee pain, stiffness, improved knee function and quality of life without severe complications.
Identifiants
pubmed: 33394073
doi: 10.1007/s00264-020-04923-0
pii: 10.1007/s00264-020-04923-0
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
627-633Références
Zhang Y, Jordan JM (2008) Epidemiology of osteoarthritis. Rheum Dis Clin N Am 34(3):515–529. https://doi.org/10.1016/j.rdc.2008.05.007
doi: 10.1016/j.rdc.2008.05.007
Fernandes L, Hagen KB, Bijlsma JW, Andreassen O, Christensen P, Conaghan PG, Doherty M, Geenen R, Hammond A, Kjeken I, Lohmander LS, Lund H, Mallen CD, Nava T, Oliver S, Pavelka K, Pitsillidou I, da Silva JA, de la Torre J, Zanoli G, Vliet Vlieland TP (2013) EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis. Ann Rheum Dis 72(7):1125–1135. https://doi.org/10.1136/annrheumdis-2012-202745
doi: 10.1136/annrheumdis-2012-202745
pubmed: 23595142
Gay C, Chabaud A, Guilley E, Coudeyre E (2016) Educating patients about the benefits of physical activity and exercise for their hip and knee osteoarthritis. Systematic literature review. Ann Phys Rehabil Med 59(3):174–183. https://doi.org/10.1016/j.rehab.2016.02.005
doi: 10.1016/j.rehab.2016.02.005
pubmed: 27053003
Pareek A, Reardon PJ, Macalena JA, Levy BA, Stuart MJ, Williams RJ 3rd, Krych AJ (2016) Osteochondral autograft transfer versus microfracture in the knee: a meta-analysis of prospective comparative studies at midterm. Arthroscopy 32(10):2118–2130. https://doi.org/10.1016/j.arthro.2016.05.038
doi: 10.1016/j.arthro.2016.05.038
pubmed: 27487736
Bistolfi A, Massazza G, Lee GC, Deledda D, Berchialla P, Crova M (2013) Comparison of fixed and mobile-bearing total knee arthroplasty at a mean follow-up of 116 months. J Bone Joint Surg Am 95(12):e83. https://doi.org/10.2106/JBJS.L.00327
doi: 10.2106/JBJS.L.00327
pubmed: 23783214
Kraeutler MJ, Belk JW, Purcell JM, McCarty EC (2018) Microfracture versus autologous chondrocyte implantation for articular cartilage lesions in the knee: a systematic review of 5-year outcomes. Am J Sports Med 46(4):995–999. https://doi.org/10.1177/0363546517701912
doi: 10.1177/0363546517701912
pubmed: 28423287
Witjes S, Gouttebarge V, Kuijer PP, van Geenen RC, Poolman RW, Kerkhoffs GM (2016) Return to sports and physical activity after total and unicondylar knee arthroplasty: a systematic review and meta-analysis. Sports Med 46(2):269–292. https://doi.org/10.1007/s40279-015-0421-9
doi: 10.1007/s40279-015-0421-9
pubmed: 26744336
pmcid: 4728176
Evans JT, Evans JP, Walker RW, Blom AW, Whitehouse MR, Sayers A (2019) How long does a hip replacement last? A systematic review and meta-analysis of case series and national registry reports with more than 15 years of follow-up. Lancet 393(10172):647–654. https://doi.org/10.1016/S0140-6736(18)31665-9
doi: 10.1016/S0140-6736(18)31665-9
pubmed: 30782340
pmcid: 6376618
Roato I, Belisario DC, Compagno M, Lena A, Bistolfi A, Maccari L, Mussano F, Genova T, Godio L, Perale G, Formica M, Cambieri I, Castagnoli C, Robba T, Felli L, Ferracini R (2019) Concentrated adipose tissue infusion for the treatment of knee osteoarthritis: clinical and histological observations. Int Orthop 43(1):15–23. https://doi.org/10.1007/s00264-018-4192-4
doi: 10.1007/s00264-018-4192-4
pubmed: 30311059
Bianchi F, Maioli M, Leonardi E, Olivi E, Pasquinelli G, Valente S, Mendez AJ, Ricordi C, Raffaini M, Tremolada C, Ventura C (2013) A new nonenzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte-like elements by mild mechanical forces from human lipoaspirates. Cell Transplant 22(11):2063–2077. https://doi.org/10.3727/096368912X657855
doi: 10.3727/096368912X657855
pubmed: 23051701
Roato I, Mussano F, Reano S, Boriani F, Margara A, Ferracini R, Adriani E, Sabry O, Fiorini M, Fattori P (2020) A novel method to optimize autologous adipose tissue recovery with extracellular matrix preservation. Processes 2020, 8(1), 58; https://doi.org/10.3390/pr8010058
Kean TJ, Lin P, Caplan AI, Dennis JE (2013) MSCs: delivery routes and engraftment, cell-targeting strategies, and immune modulation. Stem Cells Int 2013:732742. https://doi.org/10.1155/2013/732742
doi: 10.1155/2013/732742
pubmed: 24000286
pmcid: 3755386
Caplan AI, Dennis JE (2006) Mesenchymal stem cells as trophic mediators. J Cell Biochem 98(5):1076–1084. https://doi.org/10.1002/jcb.20886
doi: 10.1002/jcb.20886
pubmed: 16619257
Borić I, Hudetz D, Rod E, Jelec Z, Vrdoljak T, Skelin A, Polasek O, Plecko M, Trbojevic-Akmacic I, Lauc G, Primorac D (2019) A 24-month follow-up study of the effect of intra-articular injection of autologous microfragmented fat tissue on proteoglycan synthesis in patients with knee osteoarthritis. Genes (Basel) 10(12):1051. https://doi.org/10.3390/genes10121051
doi: 10.3390/genes10121051
Russo A, Screpis D, Di Donato SL, Bonetti S, Piovan G, Zorzi C. (2018) Autologous micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis: an update at 3 year follow-up. J Exp Orthop. 5(1):52. Published 2018 Dec 19. https://doi.org/10.1186/s40634-018-0169-x
Mautner K, Bowers R, Easley K, Fausel Z, Robinson R (2019) Functional outcomes following microfragmented adipose tissue versus bone marrow aspirate concentrate injections for symptomatic knee osteoarthritis. Stem Cells Transl Med 8(11):1149–1156. https://doi.org/10.1002/sctm.18-0285
doi: 10.1002/sctm.18-0285
pubmed: 31328447
pmcid: 6811695
Koh YG, Choi YJ, Kwon OR, Kim YS. (2014) Second-look arthroscopic evaluation of cartilage lesions after mesenchymal stem cell implantation in osteoarthritic knees. Am J Sports Med. Jul;42(7):1628-37. https://doi.org/10.1177/0363546514529641
Koh YG, Kwon OR, Kim YS, Choi YJ (2014) Comparative outcomes of open-wedge high tibial osteotomy with platelet-rich plasma alone or in combination with mesenchymal stem cell treatment: a prospective study. Arthroscopy 30(11):1453–1460. https://doi.org/10.1016/j.arthro.2014.05.036
doi: 10.1016/j.arthro.2014.05.036
pubmed: 25108907
Michalek J, Moster R, Lukac L, Proefrock K, Petrasovic M, Rybar J, Capkova M, Chaloupka A, Darinskas A, Michalek J Sr, Kristek J, Travnik J, Jabandziev P, Cibulka M, Holek M, Jurik M, Skopalik J, Kristkova Z, Dudasova Z (2015) Autologous adipose tissue-derived stromal vascular fraction cells application in patients with osteoarthritis. Cell Transplant. https://doi.org/10.3727/096368915X686760
Venkataram J (2008) Tumescent liposuction: a review. J Cutan Aesthet Surg 1(2):49–57. https://doi.org/10.4103/0974-2077.44159
doi: 10.4103/0974-2077.44159
pubmed: 20300344
pmcid: 2840906
Pu LL, Coleman SR, Cui X, Ferguson RE Jr, Vasconez HC (2008) Autologous fat grafts harvested and refined by the Coleman technique: a comparative study. Plast Reconstr Surg 122(3):932–937. https://doi.org/10.1097/PRS.0b013e3181811ff0
doi: 10.1097/PRS.0b013e3181811ff0
pubmed: 18766062
C. Tremolada, V. Colombo, C. Ventura. (2016) Adipose tissue and mesenchymal stem cells: state of the art and Lipogems technology development. Curr Stem Cell Rep. 2(3):304–312
Di Matteo B, Vandenbulcke F, Vitale ND, Iacono F, Marcacci M, Kon E (2019) Minimally manipulated mesenchymal stem cells for the treatment of knee osteoarthritis: a systematic review of clinical evidence. Stem Cells Int 2019:1735242. https://doi.org/10.1155/2019/1735242
doi: 10.1155/2019/1735242
pubmed: 31485234
pmcid: 6710724
Lee WS, Kim HJ, Kim KI, Kim GB, Jin W (2019) Intra-articular injection of autologous adipose tissue-derived mesenchymal stem cells for the treatment of knee osteoarthritis: a phase IIb, randomized, placebo-controlled clinical trial. Stem Cells Transl Med 8(6):504–511. https://doi.org/10.1002/sctm.18-0122
doi: 10.1002/sctm.18-0122
pubmed: 30835956
pmcid: 6525553
Cattaneo G, De Caro A, Napoli F, Chiapale D, Trada P, Camera A. (2018) Micro-fragmented adipose tissue injection associated with arthroscopic procedures in patients with symptomatic knee osteoarthritis. BMC Musculoskelet Disord. 30;19(1):176. https://doi.org/10.1186/s12891-018-2105-8
Spasovski D, Spasovski V, Baščarević Z, Stojiljković M, Vreća M, Anđelković M, Pavlović S. (2018) Intra-articular injection of autologous adipose-derived mesenchymal stem cells in the treatment of knee osteoarthritis. J Gene Med. 20(1): https://doi.org/10.1002/jgm.3002 . https://doi.org/10.1002/jgm.3002
Ragni E, Perucca Orfei C, De Luca P, Colombini A, Viganò M, de Girolamo L (2020) Secreted factors and EV-miRNAs orchestrate the healing capacity of adipose mesenchymal stem cells for the treatment of knee osteoarthritis. Int J Mol Sci 21(5):1582. https://doi.org/10.3390/ijms21051582
doi: 10.3390/ijms21051582
pmcid: 7084308
Migliorini F, Rath B, Colarossi G, Driessen A, Tingart M, Niewiera M, Eschweiler J (2019) Improved outcomes after mesenchymal stem cells injections for knee osteoarthritis: results at 12-months follow-up: a systematic review of the literature. Arch Orthop Trauma Surg. https://doi.org/10.1007/s00402-019-03267-8 , https://doi.org/10.1007/s00402-019-03267-8
Jo CH, Lee YG, Shin WH, Kim H, Chai JW, Jeong EC, Kim JE, Shim H, Shin JS, Shin IS, Ra JC, Oh S, Yoon KS (2014) Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. Stem Cells 32(5):1254–1266. https://doi.org/10.1002/stem.1634
doi: 10.1002/stem.1634
pubmed: 24449146
pmcid: 24449146
Koga H, Muneta T, Nagase T, Nimura A, Ju YJ, Mochizuki T, Sekiya I (2008) Comparison of mesenchymal tissues-derived stem cells for in vivo chondrogenesis: suitable conditions for cell therapy of cartilage defects in rabbit. Cell Tissue Res 333(2):207–215. https://doi.org/10.1007/s00441-008-0633-5
doi: 10.1007/s00441-008-0633-5
pubmed: 18560897
Coleman SR, Saboeiro AP (2007) Fat grafting to the breast revisited: safety and efficacy. Plast Reconstr Surg. https://doi.org/10.1097/01.prs.0000252001.59162.c9