Polygala sabulosa A.W. Bennett extract mitigates motor and cognitive deficits in a mouse model of acute ischemia.
Animals
Brain Ischemia
/ drug therapy
Cognition
/ drug effects
Cognitive Dysfunction
/ drug therapy
Disease Models, Animal
Hand Strength
Interleukin-1beta
/ metabolism
Maze Learning
/ drug effects
Mice
Motor Disorders
/ drug therapy
Motor Skills
/ drug effects
Muscle Strength
/ drug effects
Neuroprotective Agents
/ pharmacology
Plant Extracts
/ pharmacology
Polygala
Tumor Necrosis Factor-alpha
/ metabolism
Cognition
Ischemic stroke
Motor rehabilitation
Neuroprotection
Polygala sabulosa
Journal
Metabolic brain disease
ISSN: 1573-7365
Titre abrégé: Metab Brain Dis
Pays: United States
ID NLM: 8610370
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
06
10
2020
accepted:
17
12
2020
pubmed:
5
1
2021
medline:
28
10
2021
entrez:
4
1
2021
Statut:
ppublish
Résumé
Stroke is considered one of the leading causes of death worldwide. The treatment is limited; however, the Brazilian flora has a great source of natural products with therapeutic potentials. Studies with the medicinal plant Polygala sabulosa W. Bennett provided evidence for its use as an anti-inflammatory and neuroprotective drug. In the case of ischemic stroke due to lack of oxygen, both acute and chronic inflammatory processes are activated. Thus, we hypothesized that P. sabulosa (HEPs) has the potential to treat the motor and cognitive deficits generated by ischemic stroke. Male mice were subjected to global ischemia for 60 min, followed by reperfusion and orally treated with HEPs (100 mg/kg in saline + 3% tween 20) twice a day (12 h apart) for 48 h starting 3 h after surgery. Motor skills were assessed using grip force and open field tasks. Hippocampi were then collected for mRNA quantification of the cytokines IL-1-β and TNF-α levels. After 48 h of acute treatment, spatial reference memory was evaluated in a Morris water maze test for another group of animals. We show that HEPs treatment significantly prevented motor weakness induced by ischemia. Brain infarct area was reduced by 22.25% with downregulation of the levels of IL-1β and TNF-α mRNA. Learning performance and memory ability on Morris water maze task were similar to the sham group. Our data demonstrates the neuroprotective properties of HEPs through its anti-inflammatory activities, which prevent motor and cognitive impairments, suggesting that HEPs may be an effective therapy for ischemic stroke.
Identifiants
pubmed: 33394286
doi: 10.1007/s11011-020-00660-w
pii: 10.1007/s11011-020-00660-w
doi:
Substances chimiques
Interleukin-1beta
0
Neuroprotective Agents
0
Plant Extracts
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
453-462Références
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