Rewinding sarcopenia: a narrative review on the renin-angiotensin system.
Angiotensin-converting enzyme
Cognition
Exercise
Hypertension
Vitamin D
Journal
Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
29
09
2020
accepted:
21
11
2020
pubmed:
5
1
2021
medline:
14
9
2021
entrez:
4
1
2021
Statut:
ppublish
Résumé
The purpose of this review was two-fold. First, we aimed to provide an in-depth glance on the relationship between renin-angiotensin system (RAS) dysregulation and sarcopenia. Second, we aimed to touch upon potential treatments of sarcopenia (including RAS blockers, vitamin D, and exercise) in light of the pertinent literature. Currently available research regarding the effects of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers on knee extensor strength, grip strength, chair stand test, gate speed together with the effects of exercise on muscle mass, strength, physical performance, blood pressure and cognitive tests (particularly in older adults) was reviewed. Although some studies have shown favorable effects of ACEIs on muscle strength and/or physical function tests, some studies have reported no/negative association in between. The favorable impact of exercise on reducing blood pressure is shown, and exercise treatment is widely recommended in the relevant literature. Different types of exercises (aerobic, resistance, dancing, music movement, water-based, golf, knitting activities or multicomponent exercises) have shown improvement in cognitive functions as well. Classical RAS activity results in deleterious effects not only on the cardiovascular but also on the neuromusculoskeletal system. Therefore, treatments targeting inhibition of the classical RAS activity seem to be important in the management of several age-related pathologies, including sarcopenia. As such, ACEIs, vitamin D, exercise, and healthy diet can have prominent effects not only on the modulation of RAS but also on physical and cognitive functions and sarcopenia as well.
Sections du résumé
BACKGROUND AND AIMS
OBJECTIVE
The purpose of this review was two-fold. First, we aimed to provide an in-depth glance on the relationship between renin-angiotensin system (RAS) dysregulation and sarcopenia. Second, we aimed to touch upon potential treatments of sarcopenia (including RAS blockers, vitamin D, and exercise) in light of the pertinent literature.
METHODS
METHODS
Currently available research regarding the effects of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers on knee extensor strength, grip strength, chair stand test, gate speed together with the effects of exercise on muscle mass, strength, physical performance, blood pressure and cognitive tests (particularly in older adults) was reviewed.
RESULTS
RESULTS
Although some studies have shown favorable effects of ACEIs on muscle strength and/or physical function tests, some studies have reported no/negative association in between. The favorable impact of exercise on reducing blood pressure is shown, and exercise treatment is widely recommended in the relevant literature. Different types of exercises (aerobic, resistance, dancing, music movement, water-based, golf, knitting activities or multicomponent exercises) have shown improvement in cognitive functions as well.
CONCLUSION
CONCLUSIONS
Classical RAS activity results in deleterious effects not only on the cardiovascular but also on the neuromusculoskeletal system. Therefore, treatments targeting inhibition of the classical RAS activity seem to be important in the management of several age-related pathologies, including sarcopenia. As such, ACEIs, vitamin D, exercise, and healthy diet can have prominent effects not only on the modulation of RAS but also on physical and cognitive functions and sarcopenia as well.
Identifiants
pubmed: 33394457
doi: 10.1007/s40520-020-01761-3
pii: 10.1007/s40520-020-01761-3
doi:
Substances chimiques
Angiotensin Receptor Antagonists
0
Angiotensin-Converting Enzyme Inhibitors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2379-2392Informations de copyright
© 2021. Springer Nature Switzerland AG.
Références
Schmieder RE, Hilgers KF, Schlaich MP et al (2007) Renin-angiotensin system and cardiovascular risk. Lancet 369:1208–1219
pubmed: 17416265
doi: 10.1016/S0140-6736(07)60242-6
Passos-Silva DG, Verano-Braga T, Santos RA (2013) Angiotensin-(1–7): beyond the cardio-renal actions. Clin Sci (Lond) 124:443–456
doi: 10.1042/CS20120461
Cabello-Verrugio C, Morales MG, Rivera JC et al (2015) Renin-angiotensin system: an old player with novel functions in skeletal muscle. Med Res Rev 35:437–463
pubmed: 25764065
doi: 10.1002/med.21343
Chow CK, Teo KK, Rangarajan S et al (2013) Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries. JAMA 310:959–968
pubmed: 24002282
doi: 10.1001/jama.2013.184182
Castillo-Olea C, Garcia-Zapirain Soto B, Zuñiga C (2020) Evaluation of prevalence of the sarcopenia level using machine learning techniques: case study in Tijuana Baja California, Mexico. Int J Environ Res Public Health 17:1917
pmcid: 7143671
doi: 10.3390/ijerph17061917
pubmed: 7143671
Bai T, Fang F, Li F et al (2020) Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis. BMC Geriatr 20:279
pubmed: 32762638
pmcid: 7409686
doi: 10.1186/s12877-020-01672-y
Song YH, Li Y, Du J et al (2005) Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting. J Clin Investig 115:451–458
pubmed: 15650772
pmcid: 544037
doi: 10.1172/JCI22324
Burks TN, Andres-Mateos E, Marx R et al (2011) Losartan restores skeletal muscle remodeling and protects against disuse atrophy in sarcopenia. Sci Transl Med 3:82ra37
pubmed: 21562229
pmcid: 3140459
doi: 10.1126/scitranslmed.3002227
Cabello-Verrugio C, Acuña MJ, Morales MG et al (2011) Fibrotic response induced by angiotensin-II requires NAD(P)H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells. Biochem Biophys Res Commun 410:665–670
pubmed: 21693104
doi: 10.1016/j.bbrc.2011.06.051
Ábrigo J, Simon F, Cabrera D et al (2016) Angiotensin-(1–7) prevents skeletal muscle atrophy induced by transforming growth factor type beta (TGF-β) via Mas receptor activation. Cell Physiol Biochem 40:27–38
pubmed: 27842312
doi: 10.1159/000452522
Bader M, Santos RA, Unger T et al (2012) New therapeutic pathways in the RAS. J Renin Angiotensin Aldosterone Syst 13:505–508
pubmed: 23166114
doi: 10.1177/1470320312466519
Takane K, Hasegawa Y, Lin B et al (2017) Detrimental effects of centrally administered angiotensin II are enhanced in a mouse model of Alzheimer disease independently of blood pressure. J Am Heart Assoc 6:e004897
pubmed: 28428194
pmcid: 5533006
doi: 10.1161/JAHA.116.004897
Pelisch N, Hosomi N, Mori H et al (2013) RAS inhibition attenuates cognitive impairment by reducing blood- brain barrier permeability in hypertensive subjects. Curr Hypertens Rev 9:93–98
pubmed: 23971690
doi: 10.2174/15734021113099990003
Mogi M, Iwanami J, Horiuchi M (2012) Roles of brain angiotensin II in cognitive function and dementia. Int J Hypertens 2012:169649
pubmed: 23304450
pmcid: 3529904
doi: 10.1155/2012/169649
Rosenberg IH (1989) Epidemiologic and methodologic problems in determining nutritional status of older persons. (summary comments). Am J Cli Nutr 50:1231–1233
doi: 10.1093/ajcn/50.5.1231
Kara M, Özçakar L, Kaymak B et al (2020) A “neuromuscular look” to sarcopenia: is it a movement disorder? J Rehabil Med 52:jrm00042
pubmed: 32253444
doi: 10.2340/16501977-2672
Kara M, Kaymak B, Ata AM et al (2020) STAR—sonographic thigh adjustment ratio: a golden formula for the diagnosis of sarcopenia. Am J Phys Med Rehabil 99:902–908
pubmed: 32941253
doi: 10.1097/PHM.0000000000001439
Cruz-Jentoft AJ, Bahat G, Bauer J et al (2019) Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48:16–31
doi: 10.1093/ageing/afy169
Chen LK, Woo J, Assantachai P et al (2020) Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc 21:300–307.e2
doi: 10.1016/j.jamda.2019.12.012
McLean RR, Shardell MD, Alley DE et al (2014) Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: the foundation for the National Institutes of Health (FNIH) sarcopenia project. J Gerontol A Biol Sci Med Sci 69:576–583
pubmed: 24737560
pmcid: 3991140
doi: 10.1093/gerona/glu012
Studenski SA, Peters KW, Alley DE et al (2014) The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci 69:547–558
pubmed: 24737557
pmcid: 3991146
doi: 10.1093/gerona/glu010
Auyeung TW, Lee JS, Kwok T et al (2011) Physical frailty predicts future cognitive decline—a four-year prospective study in 2737 cognitively normal older adults. J Nutr Health Aging 15:690–694
pubmed: 21968866
doi: 10.1007/s12603-011-0110-9
Chou MY, Nishita Y, Nakagawa T et al (2019) Role of gait speed and grip strength in predicting 10-year cognitive decline among community-dwelling older people. BMC Geriatr 19:186
pubmed: 31277579
pmcid: 6612180
doi: 10.1186/s12877-019-1199-7
Zammit AR, Piccinin AM, Duggan EC et al (2019) A coordinated multi-study analysis of the longitudinal association between handgrip strength and cognitive function in older adults. J Gerontol B Psychol Sci Soc Sci. https://doi.org/10.1093/geronb/gbz072
doi: 10.1093/geronb/gbz072
Dumurgier J, Elbaz A, Dufouil C et al (2010) Hypertension and lower walking speed in the elderly: the three-city study. J Hypertens 28:1506–1514
pubmed: 20404744
pmcid: 4851985
doi: 10.1097/HJH.0b013e328338bbec
Ata AM, Kara M, Kaymak B et al (2019) Regional and total muscle mass, muscle strength and physical performance: the potential use of ultrasound imaging for sarcopenia. Arch Gerontol Geriatr 83:55–60
pubmed: 30953961
doi: 10.1016/j.archger.2019.03.014
Tsukasaki K, Matsui Y, Arai H et al (2020) Association of muscle strength and gait speed with cross-sectional muscle area determined by mid-thigh computed tomography—a comparison with skeletal muscle mass measured by dual-energy X-ray absorptiometry. J Frailty Aging 9:82–89
pubmed: 32259181
Minetto MA, Caresio C, Menapace T et al (2016) Ultrasound-based detection of low muscle mass for diagnosis of sarcopenia in older adults. PM R 8:453–462
pubmed: 26431809
doi: 10.1016/j.pmrj.2015.09.014
Özçakar L, Ata AM, Kaymak B, Kara M, Kumbhare D (2018) Ultrasound imaging for sarcopenia, spasticity and painful muscle syndromes. Curr Opin Support Palliat Care 12:373–381
pubmed: 29912727
doi: 10.1097/SPC.0000000000000354
Özçakar L, Kara M, Quittan M et al (2020) The need for an integrative musculoskeletal approach in sarcopenia: the ISarcoPRM kickstart. Eur J Phys Rehabil Med 56:535–536
pubmed: 32293814
doi: 10.23736/S1973-9087.20.06255-3
Ata AM, Kara M, Kaymak B et al (2020) “Zooming” in the anterior thigh muscle for the diagnosis of sarcopenia. J Am Geriatr Soc 68:1878–1879
pubmed: 32533843
doi: 10.1111/jgs.16572
Lionakis N, Mendrinos D, Sanidas E et al (2012) Hypertension in the elderly. World J Cardiol 4:135–147
pubmed: 22655162
pmcid: 3364500
doi: 10.4330/wjc.v4.i5.135
Heart Outcomes Prevention Evaluation Study Investigators, Yusuf S, Sleight P et al (2000) Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med 342:145–153
doi: 10.1056/NEJM200001203420301
Buford TW, Manini TM, Hsu FC et al (2012) Angiotensin-converting enzyme inhibitor use by older adults is associated with greater functional responses to exercise. J Am Geriatr Soc 60:1244–1252
pubmed: 22726232
pmcid: 3625953
doi: 10.1111/j.1532-5415.2012.04045.x
Chappell MC, Pirro NT, Sykes A et al (1998) Metabolism of angiotensin-(1–7) by angiotensin-converting enzyme. Hypertension 31:362–367
pubmed: 9453329
doi: 10.1161/01.HYP.31.1.362
Sumukadas D, Price R, McMurdo MET et al (2018) The effect of perindopril on postural instability in older people with a history of falls-a randomised controlled trial. Age Ageing 47:75–81
pubmed: 28985263
doi: 10.1093/ageing/afx127
Sumukadas D, Band M, Miller S et al (2014) Do ACE inhibitors improve the response to exercise training in functionally impaired older adults? A randomized controlled trial. J Gerontol A Biol Sci Med Sci 69:736–743
pubmed: 24201696
doi: 10.1093/gerona/glt142
Brown JD, Smith SM, Strotmeyer ES et al (2020) Comparative effects of ACE inhibitors and ARBs on response to a physical activity intervention in older adults: results from Lifestyle Interventions for Elders (LIFE) study. J Gerontol A Biol Sci Med Sci 75:1010–1016
pubmed: 31070702
doi: 10.1093/gerona/glz120
Cesari M, Pedone C, Incalzi RA et al (2010) ACE-inhibition and physical function: results from the trial of angiotensin-converting enzyme inhibition and novel cardiovascular risk factors (TRAIN) study. J Am Med Dir Assoc 11:26–32
pubmed: 20129212
doi: 10.1016/j.jamda.2009.09.014
Sumukadas D, Witham MD, Struthers AD et al (2007) Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial. CMAJ 177:867–874
pubmed: 17923654
pmcid: 1995143
doi: 10.1503/cmaj.061339
Bea JW, Wassertheil-Smoller S, Wertheim BC et al (2018) Associations between ACE-Inhibitors, angiotensin receptor blockers, and lean body mass in community dwelling older women. J Aging Res 2018:8491092
pubmed: 29670769
pmcid: 5836326
doi: 10.1155/2018/8491092
Baptista LC, Machado-Rodrigues AM, Veríssimo MT et al (2018) Exercise training improves functional status in hypertensive older adults under angiotensin converting enzymes inhibitors medication. Exp Gerontol 109:82–89
pubmed: 28645696
doi: 10.1016/j.exger.2017.06.013
Gray SL, Aragaki AK, LaMonte MJ et al (2012) Statins, angiotensin-converting enzyme inhibitors, and physical performance in older women. J Am Geriatr Soc 60:2206–2214
pubmed: 23176078
pmcid: 3521070
doi: 10.1111/jgs.12029
Bunout D, Barrera G, de la Maza MP et al (2009) Effects of enalapril or nifedipine on muscle strength or functional capacity in elderly subjects. A double blind trial. J Renin Angiotensin Aldosterone Syst 10:77–84
pubmed: 19502254
doi: 10.1177/1470320309105338
Schellenbaum GD, Smith NL, Heckbert SR et al (2005) Weight loss, muscle strength, and angiotensin-converting enzyme inhibitors in older adults with congestive heart failure or hypertension. J Am Geriatr Soc 53:1996–2000
pubmed: 16274385
doi: 10.1111/j.1532-5415.2005.53568.x
Onder G, Penninx BW, Balkrishnan R et al (2002) Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study. Lancet 359:926–930
pubmed: 11918911
doi: 10.1016/S0140-6736(02)08024-8
Kostka J, Sikora J, Kostka T (2017) Relationship of quadriceps muscle power and optimal shortening velocity with angiotensin-converting enzyme activity in older women. Clin Interv Aging 12:1753–1760
pubmed: 29089749
pmcid: 5656348
doi: 10.2147/CIA.S146494
George CJ, Verghese J (2016) Gait Performance in hypertensive patients on angiotensin-converting enzyme inhibitors. J Am Med Dir Assoc 17:737–740
pubmed: 27209273
pmcid: 8164386
doi: 10.1016/j.jamda.2016.03.022
Coelho VA, Probst VS, Nogari BM et al (2016) Angiotensin-II blockage, muscle strength, and exercise capacity in physically independent older adults. J Phys Ther Sci 28:547–552
pubmed: 27065543
pmcid: 4793008
doi: 10.1589/jpts.28.547
Spira D, Walston J, Buchmann N et al (2016) Angiotensin-converting enzyme inhibitors and parameters of sarcopenia: Relation to muscle mass, strength and function: data from the Berlin Aging Study-II (BASE-II). Drugs Aging 33:829–837
pubmed: 27665105
doi: 10.1007/s40266-016-0396-8
Di Bari M, van de Poll-Franse LV, Onder G et al (2004) Antihypertensive medications and differences in muscle mass in older persons: the Health, Aging and Body Composition Study. J Am Geriatr Soc 52:961–966
pubmed: 15161462
doi: 10.1111/j.1532-5415.2004.52265.x
Ata AM, Kara M, Ekiz T et al (2020) Reassessing sarcopenia in hypertension: STAR and ACE inhibitors excel. Int J Clin Pract. https://doi.org/10.1111/ijcp.13800
doi: 10.1111/ijcp.13800
pubmed: 33108697
Lappe JM, Binkley N (2015) Vitamin D and sarcopenia/falls. J Clin Densitom 18:478–482
pubmed: 26059567
doi: 10.1016/j.jocd.2015.04.015
D’Amelio P, Quacquarelli L (2020) Hypovitaminosis D and aging: is there a role in muscle and brain health? Nutrients 12:628
pmcid: 7146116
doi: 10.3390/nu12030628
pubmed: 7146116
Beaudart C, Dawson A, Shaw SC et al (2017) Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review. Osteoporos Int 28:1817–1833
pubmed: 28251287
pmcid: 5457808
doi: 10.1007/s00198-017-3980-9
Legarth C, Grimm D, Wehland M et al (2018) The impact of vitamin D in the treatment of essential hypertension. Int J Mol Sci 19:455
pmcid: 5855677
doi: 10.3390/ijms19020455
pubmed: 5855677
Li YC, Kong J, Wei M et al (2002) 1,25-dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Investig 110:229–238
pubmed: 12122115
pmcid: 151055
doi: 10.1172/JCI0215219
Azadpour N, Tartibian B, Koşar ŞN (2017) Effects of aerobic exercise training on ACE and ADRB2 gene expression, plasma angiotensin II level, and flow-mediated dilation: a study on obese postmenopausal women with prehypertension. Menopause 24:269–277
pubmed: 28231078
doi: 10.1097/GME.0000000000000762
Busse AL, Gil G, Santarém JM et al (2009) Physical activity and cognition in the elderly: a review. Dement Neuropsychol 3:204–208
pubmed: 29213629
pmcid: 5618974
doi: 10.1590/S1980-57642009DN30300005
Oliveira-Dantas FF, Brasileiro-Santos MDS, Thomas SG et al (2020) Short-term resistance training improves cardiac autonomic modulation and blood pressure in hypertensive older women: a randomized controlled trial. J Strength Cond Res 34:37–45
pubmed: 31877119
doi: 10.1519/JSC.0000000000003182
Baggen RJ, Van Roie E, Verschueren SM et al (2019) Bench stepping with incremental heights improves muscle volume, strength and functional performance in older women. Exp Gerontol 120:6–14
pubmed: 30797825
doi: 10.1016/j.exger.2019.02.013
pmcid: 30797825
Van Roie E, Walker S, Van Driessche S et al (2017) Training load does not affect detraining’s effect on muscle volume, muscle strength and functional capacity among older adults. Exp Gerontol 98:30–37
pubmed: 28778747
doi: 10.1016/j.exger.2017.07.017
pmcid: 28778747
Reid KF, Martin KI, Doros G et al (2015) Comparative effects of light or heavy resistance power training for improving lower extremity power and physical performance in mobility-limited older adults. J Gerontol A Biol Sci Med Sci 70:374–380
pubmed: 25199912
doi: 10.1093/gerona/glu156
pmcid: 25199912
Jefferson ME, Nicklas BJ, Chmelo EA et al (2016) Effects of resistance training with and without caloric restriction on arterial stiffness in overweight and obese older adults. Am J Hypertens 29:494–500
pubmed: 26297029
doi: 10.1093/ajh/hpv139
pmcid: 26297029
Cadore EL, Casas-Herrero A, Zambom-Ferraresi F et al (2014) Multicomponent exercises including muscle power training enhance muscle mass, power output, and functional outcomes in institutionalized frail nonagenarians. Age (Dordr) 36:773–785
doi: 10.1007/s11357-013-9586-z
Dos Santos ES, Asano RY, Filho IG et al (2014) Acute and chronic cardiovascular response to 16 weeks of combined eccentric or traditional resistance and aerobic training in elderly hypertensive women: a randomized controlled trial. J Strength Cond Res 28:3073–3084
pubmed: 24845208
doi: 10.1519/JSC.0000000000000537
pmcid: 24845208
Sousa N, Mendes R, Abrantes C et al (2013) A randomized 9-month study of blood pressure and body fat responses to aerobic training versus combined aerobic and resistance training in older men. Exp Gerontol 48:727–733
pubmed: 23628502
doi: 10.1016/j.exger.2013.04.008
Wallerstein LF, Tricoli V, Barroso R et al (2012) Effects of strength and power training on neuromuscular variables in older adults. J Aging Phys Act 20:171–185
pubmed: 22472578
doi: 10.1123/japa.20.2.171
Goodpaster BH, Chomentowski P, Ward BK et al (2008) Effects of physical activity on strength and skeletal muscle fat infiltration in older adults: a randomized controlled trial. J Appl Physiol (1985) 105:1498–1503
doi: 10.1152/japplphysiol.90425.2008
Stewart KJ, Bacher AC, Turner KL et al (2005) Effect of exercise on blood pressure in older persons: a randomized controlled trial. Arch Intern Med 165:756–762
pubmed: 15824294
doi: 10.1001/archinte.165.7.756
Kalapotharakos VI, Michalopoulou M, Godolias G et al (2004) The effects of high- and moderate-resistance training on muscle function in the elderly. J Aging Phys Act 12:131–143
pubmed: 15223882
doi: 10.1123/japa.12.2.131
Sipilä S, Suominen H (1995) Effects of strength and endurance training on thigh and leg muscle mass and composition in elderly women. J Appl Physiol (1985) 78:334–340
doi: 10.1152/jappl.1995.78.1.334
Katsoulis K, Stathokostas L, Amara CE (2019) The effects of high- versus low-intensity power training on muscle power outcomes in healthy, older adults: a systematic review. J Aging Phys Act 27:422–439
pubmed: 30300075
doi: 10.1123/japa.2018-0054
Miszko TA, Cress ME, Slade JM et al (2003) Effect of strength and power training on physical function in community-dwelling older adults. J Gerontol A Biol Sci Med Sci 58:171–175
pubmed: 12586856
doi: 10.1093/gerona/58.2.M171
Williams B, Mancia G, Spiering W et al (2018) 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J 39:3021–3104
pubmed: 30165516
pmcid: 30165516
doi: 10.1093/eurheartj/ehy339
Whelton PK, Carey RM, Aronow WS et al (2018) 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension 71:e13–e115
pubmed: 29133356
Naci H, Salcher-Konrad M, Dias S et al (2019) How does exercise treatment compare with antihypertensive medications? A network meta-analysis of 391 randomised controlled trials assessing exercise and medication effects on systolic blood pressure. Br J Sports Med 53:859–869
pubmed: 30563873
doi: 10.1136/bjsports-2018-099921
Winslow MA, Hall SE (2019) Muscle wasting: a review of exercise, classical and non-classical RAS axes. J Cell Mol Med 23:5836–5845
pubmed: 31273946
pmcid: 6714228
doi: 10.1111/jcmm.14412
Gomes-Santos IL, Fernandes T, Couto GK et al (2014) Effects of exercise training on circulating and skeletal muscle renin-angiotensin system in chronic heart failure rats. PLoS One 9:e98012
pubmed: 24859374
pmcid: 4032232
doi: 10.1371/journal.pone.0098012
Garber CE, Blissmer B, Deschenes MR et al (2011) American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc 43:1334–1359
pubmed: 21694556
pmcid: 21694556
doi: 10.1249/MSS.0b013e318213fefb
Esmail A, Vrinceanu T, Lussier M et al (2020) Effects of dance/movement training vs. aerobic exercise training on cognition, physical fitness and quality of life in older adults: a randomized controlled trial. J Bodyw Mov Ther 24:212–220
pubmed: 31987547
doi: 10.1016/j.jbmt.2019.05.004
CastroCoelho EM, GonçalvesdaMota MP, Fernandes F et al (2020) Exercise with music: an innovative approach to increase cognition and reduce depression in institutionalized elderly. Revista de Psicología del Deporte 29:49–56
Norouzi E, Vaezmosavi M, Gerber M et al (2019) Dual-task training on cognition and resistance training improved both balance and working memory in older people. Phys Sports Med 47:471–478
doi: 10.1080/00913847.2019.1623996
Romera-Liebana L, Orfila F, Segura JM et al (2018) Effects of a primary care-based multifactorial intervention on physical and cognitive function in frail, elderly individuals: a randomized controlled trial. J Gerontol A Biol Sci Med Sci 73:1668–1674
pmcid: 6248206
doi: 10.1093/gerona/glx259
pubmed: 6248206
Shimada H, Lee S, Akishita M et al (2018) Effects of golf training on cognition in older adults: a randomised controlled trial. J Epidemiol Community Health 72:944–950
pubmed: 29936419
doi: 10.1136/jech-2017-210052
Tarazona-Santabalbina FJ, Gómez-Cabrera MC, Pérez-Ros P et al (2016) A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial. J Am Med Dir Assoc 17:426–433
pubmed: 26947059
doi: 10.1016/j.jamda.2016.01.019
Laksmidewi AAAP, Sudewi AAR, Adiputra N et al (2019) Brain vitalization gymnastics improved cognitive function marked by increased BDNF, decreased serum interleukin-6 and decreased S-100nd expression among elderly in West Denpasar Primary Health Clinic. Open Access Maced J Med Sci 7:3596–3602
pubmed: 32010383
pmcid: 6986523
doi: 10.3889/oamjms.2019.733
Bento-Torres NVO, Bento-Torres J, Tomás AM et al (2019) Water-based exercise and resistance training improve cognition in older adults. Rev Bras Med Esporte 25:71–75
doi: 10.1590/1517-869220192501190627
Geda YE, Topazian HM, Roberts LA et al (2011) Engaging in cognitive activities, aging, and mild cognitive impairment: a population-based study. J Neuropsychiatry Clin Neurosci 23:149–154
pubmed: 21677242
pmcid: 3204924
doi: 10.1176/jnp.23.2.jnp149