Interaction of diabetes genetic risk and successful lifestyle modification in the Diabetes Prevention Programme.

Diabetes Mellitus, Type 2 / epidemiology Exercise Humans Life Style Risk Factors Weight Loss

Journal

Diabetes, obesity & metabolism
ISSN: 1463-1326
Titre abrégé: Diabetes Obes Metab
Pays: England
ID NLM: 100883645

Informations de publication

Date de publication:
04 2021
Historique:
revised: 20 12 2020
received: 23 09 2020
accepted: 23 12 2020
pubmed: 5 1 2021
medline: 10 7 2021
entrez: 4 1 2021
Statut: ppublish

Résumé

To test whether diabetes genetic risk modifies the association of successful lifestyle changes with incident diabetes. We studied 823 individuals randomized to the intensive lifestyle intervention (ILS) arm of the Diabetes Prevention Programme who were diabetes-free 1 year after enrolment. We tested additive and multiplicative interactions of a 67-variant diabetes genetic risk score (GRS) with achievement of three ILS goals at 1 year (≥7% weight loss, ≥150 min/wk of moderate leisure-time physical activity, and/or a goal for self-reported total fat intake) on the primary outcome of incident diabetes over 3 years of follow-up. A lower GRS and achieving each or all three ILS goals were each associated with lower incidence of diabetes (all P < 0.05). Additive interactions were significant between the GRS and achievement of the weight loss goal (P < 0.001), physical activity goal (P = 0.02), and all three ILS goals (P < 0.001) for diabetes risk. Achievement of all three ILS goals was associated with 1.8 (95% CI 0.3, 3.4), 3.1 (95% CI 1.5, 4.7), and 3.9 (95% CI 1.6, 6.2) fewer diabetes cases/100-person-years in the first, second and third GRS tertiles (P < 0.001 for trend). Multiplicative interactions between the GRS and ILS goal achievement were significant for the diet goal (P < 0.001), but not for weight loss (P = 0.18) or physical activity (P = 0.62) goals. Genetic risk may identify high-risk subgroups for whom successful lifestyle modification is associated with greater absolute reduction in the risk of incident diabetes.

Identifiants

DOI: 10.1111/dom.14309 PMID: 33394545 PMC: PMC8852694
pubmed: 33394545
doi: 10.1111/dom.14309
pmc: PMC8852694
mid: NIHMS1776403
doi:

Types de publication

Journal Article Randomized Controlled Trial Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1030-1040

Subventions

Organisme : NIDDK NIH HHS
ID : U01 DK048412
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048375
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048434
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048413
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK116073
Pays : United States
Organisme : CSRD VA
ID : IK2 CX001907
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048468
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048387
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048404
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048437
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048407
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048397
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048381
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK111022
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048339
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048411
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048443
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048380
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048400
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048489
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048349
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2020 John Wiley & Sons Ltd.

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Auteurs

Sridharan Raghavan (S)

Medicine Service, Department of Veterans Affairs Eastern Colorado Healthcare System, Aurora, Colorado, USA.
Division of Hospital Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
Colorado Cardiovascular Outcomes Research Consortium, Aurora, Colorado, USA.
Centre for Lifecourse Epidemiology of Adiposity and Diabetes, Colorado School of Public Health, Aurora, Colorado, USA.
ORCID: 0000-0003-0643-4873

Kathleen Jablonski (K)

Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, George Washington University, Washington, District of Columbia, USA.

Linda M Delahanty (LM)

Diabetes Unit and Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Nisa M Maruthur (NM)

Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Aaron Leong (A)

Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Division of General Internal Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Paul W Franks (PW)

Department of Clinical Science, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Centre, Malmö, Sweden.
ORCID: 0000-0002-0520-7604

William C Knowler (WC)

Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA.

Jose C Florez (JC)

Diabetes Unit and Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Centre for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.

Dana Dabelea (D)

Centre for Lifecourse Epidemiology of Adiposity and Diabetes, Colorado School of Public Health, Aurora, Colorado, USA.
Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado, USA.

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Classifications MeSH

questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Interaction of diabetes genetic risk and...
questionsmedicales.fr › Activités humaines › Exercice physique › Interaction of diabetes genetic risk and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Interaction of diabetes genetic risk and...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Mode de vie › Interaction of diabetes genetic risk and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Interaction of diabetes genetic risk and...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Mensurations corporelles › Poids › Modifications du poids corporel › Perte de poids › Interaction of diabetes genetic risk and...