Intramedullary Antibiotic Depot Does Not Preclude Successful Intramedullary Lengthening or Compression.
Journal
Journal of orthopaedic trauma
ISSN: 1531-2291
Titre abrégé: J Orthop Trauma
Pays: United States
ID NLM: 8807705
Informations de publication
Date de publication:
01 08 2021
01 08 2021
Historique:
accepted:
22
12
2020
pubmed:
5
1
2021
medline:
7
8
2021
entrez:
4
1
2021
Statut:
ppublish
Résumé
The challenging problem of long bone infection and limb length difference cannot be addressed using only an antibiotic-coated nonmagnetic static nail. The combined use of resorbable calcium sulfate and magnetic lengthening nails offers a possible solution to this dilemma, as well as for infected nonunions that require compression. We present a combined technique to treat or prevent infection using femoral or tibial intramedullary antibiotic delivery with an absorbable calcium sulfate depot and concomitant internal lengthening or compression using a nail. Adequate débridement is required in cases of established infection and is a prerequisite for this technique.
Identifiants
pubmed: 33395176
doi: 10.1097/BOT.0000000000002054
pii: 00005131-202108000-00016
pmc: PMC8253503
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e309-e314Informations de copyright
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.
Références
Kirane YM, Fragomen AT, Rozbruch SR. Precision of the PRECICE® internal bone lengthening nail. Clin Orthop. 2014;472:3869–3878.
Wagner P, Burghardt RD, Green SA, et al. PRECICE magnetically-driven, telescopic, intramedullary lengthening nail: pre-clinical testing and first 30 patients. SICOT-J. 2017;3:19.
Calder PR, McKay JE, Timms AJ, et al. Femoral lengthening using the Precice intramedullary limb-lengthening system: outcome comparison following antegrade and retrograde nails. Bone Joint J. 2019;101-B:1168–1176.
Nasto LA, Coppa V, Riganti S, et al. Clinical results and complication rates of lower limb lengthening in paediatric patients using the PRECICE 2 intramedullary magnetic nail: a multicentre study. J Pediatr Orthop B. 2020;29:611–617.
Baumgart R, Betz A, Schweiberer L. A fully implantable motorized intramedullary nail for limb lengthening and bone transport. Clin Orthop. 1997;343:135–143.
Paley D. PRECICE intramedullary limb lengthening system. Expert Rev Med Devices. 2015;12:231–249.
Kurtz AM, Rozbruch SR. Humerus lengthening with the PRECICE internal lengthening nail. J Pediatr Orthop. 2017;37:e296–e300.
Hammouda AI, Standard SC, Robert Rozbruch S, et al. Humeral lengthening with the PRECICE magnetic lengthening nail. HSS J Musculoskelet J Hosp Spec Surg. 2017;13:217–223.
Hammouda AI, Jauregui JJ, Gesheff MG, et al. Treatment of post-traumatic femoral discrepancy with PRECICE magnetic-powered intramedullary lengthening nails. J Orthop Trauma. 2017;31:369–374.
Fragomen AT, Wellman D, Rozbruch SR. The PRECICE magnetic IM compression nail for long bone nonunions: a preliminary report. Arch Orthop Trauma Surg. 2019;139:1551–1560.
Marsh DR, Shah S, Elliott J, et al. The Ilizarov method in nonunion, malunion and infection of fractures. J Bone Joint Surg Br. 1997;79:273–279.
Song H-R, Oh C-W, Mattoo R, et al. Femoral lengthening over an intramedullary nail using the external fixator: risk of infection and knee problems in 22 patients with a follow-up of 2 years or more. Acta Orthop. 2005;76:245–252.
Metsemakers W-J, Handojo K, Reynders P, et al. Individual risk factors for deep infection and compromised fracture healing after intramedullary nailing of tibial shaft fractures: a single centre experience of 480 patients. Injury. 2015;46:740–745.
Yokoyama K, Itoman M, Uchino M, et al. Immediate versus delayed intramedullary nailing for open fractures of the tibial shaft: a multivariate analysis of factors affecting deep infection and fracture healing. Indian J Orthop. 2008;42:410–419.
Uchiyama Y, Kobayashi Y, Ebihara G, et al. Retrospective comparison of postoperative infection and bone union between late and immediate intramedullary nailing of Gustilo grades I, II, and IIIA open tibial shaft fractures. Trauma Surg Acute Care Open. 2016;1:e000035.
Cierny G, Mader JT. Adult chronic osteomyelitis. Orthopedics. 1984;7:1557–1564.
Tong CW, Hung LK, Cheng JC. Lengthening of a one-bone forearm. A sequel of neonatal osteomyelitis. J Hand Surg Edinb Scotl. 1998;23:453–456.
Kocaoglu M, Eralp L, Rashid HU, et al. Reconstruction of segmental bone defects due to chronic osteomyelitis with use of an external fixator and an intramedullary nail. J Bone Joint Surg Am. 2006;88:2137–2145.
Marais LC, Ferreira N. Bone transport through an induced membrane in the management of tibial bone defects resulting from chronic osteomyelitis. Strateg Trauma Limb Reconstr Online. 2015;10:27–33.
Calhoun JH, Manring MM, Shirtliff M. Osteomyelitis of the long bones. Semin Plast Surg. 2009;23:59–72.
Motsitsi NS. Management of infected nonunion of long bones: the last decade (1996-2006). Injury. 2008;39:155–160.
Conway J, Mansour J, Kotze K, et al. Antibiotic cement-coated rods: an effective treatment for infected long bones and prosthetic joint nonunions. Bone Joint J. 2014;96-B:1349–1354.
Sadek AF, Laklok MA, Fouly EH, et al. Two stage reconstruction versus bone transport in management of resistant infected tibial diaphyseal nonunion with a gap. Arch Orthop Trauma Surg. 2016;136:1233–1241.
Barger J, Fragomen AT, Rozbruch SR. Antibiotic-coated interlocking intramedullary nail for the treatment of long-bone osteomyelitis. JBJS Rev. 2017;5:e5.
Qiang Z, Jun PZ, Jie XJ, et al. Use of antibiotic cement rod to treat intramedullary infection after nailing: preliminary study in 19 patients. Arch Orthop Trauma Surg. 2007;127:945–951.
Sancineto CF, Barla JD. Treatment of long bone osteomyelitis with a mechanically stable intramedullar antibiotic dispenser: nineteen consecutive cases with a minimum of 12 months follow-up. J Trauma. 2008;65:1416–1420.
Madanagopal SG, Seligson D, Roberts CS. The antibiotic cement nail for infection after tibial nailing. Orthopedics. 2004;27:709–712.
Bhadra AK, Roberts CS. Indications for antibiotic cement nails. J Orthop Trauma. 2009;23(5 suppl):S26–S30.
Thonse R, Conway JD. Antibiotic cement-coated nails for the treatment of infected nonunions and segmental bone defects. J Bone Joint Surg Am. 2008;90(suppl 4):163–174.
McNally MA, Ferguson JY, Lau ACK, et al. Single-stage treatment of chronic osteomyelitis with a new absorbable, gentamicin-loaded, calcium sulphate/hydroxyapatite biocomposite: a prospective series of 100 cases. Bone Joint J. 2016;98-B:1289–1296.
Luo S, Jiang T, Yang Y, et al. Combination therapy with vancomycin-loaded calcium sulfate and vancomycin-loaded PMMA in the treatment of chronic osteomyelitis. BMC Musculoskelet Disord. 2016;17:502.
Howlin RP, Brayford MJ, Webb JS, et al. Antibiotic-loaded synthetic calcium sulfate beads for prevention of bacterial colonization and biofilm formation in periprosthetic infections. Antimicrob Agents Chemother. 2015;59:111–120.
Laycock PA, Cooper JJ, Howlin RP, et al. In vitro efficacy of antibiotics released from calcium sulfate bone void filler beads. Materials. 2018;11:2265.
Nelson CL, McLaren SG, Skinner RA, et al. The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets. J Orthop Res Off Publ Orthop Res Soc. 2002;20:643–647.
McConoughey SJ, Howlin RP, Wiseman J, et al. Comparing PMMA and calcium sulfate as carriers for the local delivery of antibiotics to infected surgical sites. J Biomed Mater Res B Appl Biomater. 2015;103:870–877.
Wahl P, Rönn K, Bohner M, et al. In vitro study of new combinations for local antibiotic therapy with calcium sulphate - near constant release of ceftriaxone offers new treatment options. J Bone Joint Infect. 2018;3:212–221.
Kanellakopoulou K, Panagopoulos P, Giannitsioti E, et al. In vitro elution of daptomycin by a synthetic crystallic semihydrate form of calcium sulfate, Stimulan. Antimicrob Agents Chemother. 2009;53:3106–3107.
Ferguson J, Diefenbeck M, McNally M. Ceramic biocomposites as biodegradable antibiotic carriers in the treatment of bone infections. J Bone Joint Infect. 2017;2:38–51.
Ferguson JY, Dudareva M, Riley ND, et al. The use of a biodegradable antibiotic-loaded calcium sulphate carrier containing tobramycin for the treatment of chronic osteomyelitis: a series of 195 cases. Bone Joint J. 2014;96-B:829–836.
Turner TM, Urban RM, Hall DJ, et al. Local and systemic levels of tobramycin delivered from calcium sulfate bone graft substitute pellets. Clin Orthop. 2005;437:97–104.
Badie AA, Arafa MS. One-stage surgery for adult chronic osteomyelitis: concomitant use of antibiotic-loaded calcium sulphate and bone marrow aspirate. Int Orthop. 2019;43:1061–1070.
Lum ZC, Pereira GC. Local bio-absorbable antibiotic delivery in calcium sulfate beads in hip and knee arthroplasty. J Orthop. 2018;15:676–678.
Bliskunov AI. Intramedullary distraction of the femur (preliminary report) [in Russian]. Ortop Travmatol Protez. 1983;10:59–62.
Cole JD, Justin D, Kasparis T, et al. The intramedullary skeletal kinetic distractor (ISKD): first clinical results of a new intramedullary nail for lengthening of the femur and tibia. Injury. 2001;32(suppl 4):SD129–139.
Singh S, Lahiri A, Iqbal M. The results of limb lengthening by callus distraction using an extending intramedullary nail (Fitbone) in non-traumatic disorders. J Bone Joint Surg Br. 2006;88:938–942.
Green S, Fragomen A, Herzenberg JE, et al. A magnetically controlled lengthening nail: a prospective study of 31 individuals (The PRECICE TM intramedullary nail study). J Limb Lengthening Reconstr. 2018;4:67.
Wiebking U, Liodakis E, Kenawey M, et al. Limb lengthening using the PRECICE(TM) Nail System: complications and results. Arch Trauma Res. 2016;5:e36273.
Laubscher M, Mitchell C, Timms A, et al. Outcomes following femoral lengthening: an initial comparison of the Precice intramedullary lengthening nail and the LRS external fixator monorail system. Bone Joint J. 2016;98-B:1382–1388.
Morrison TA, Sontich JK. Premature consolidation with resultant implant failure using PRECICE femoral nail lengthening: a case report. JBJS Case Connect. 2016;6:e2.