Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.
Animals
Antitubercular Agents
/ chemistry
Bacterial Proteins
/ antagonists & inhibitors
Half-Life
Humans
Iron
/ metabolism
Male
Membrane Transport Proteins
/ genetics
Mice
Mice, Inbred C57BL
Microbial Sensitivity Tests
Microsomes
/ metabolism
Mutation
Mycobacterium tuberculosis
/ drug effects
Pyrazoles
/ chemistry
Pyrimidinones
/ chemistry
Rats
Structure-Activity Relationship
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
14 01 2021
14 01 2021
Historique:
pubmed:
5
1
2021
medline:
17
2
2021
entrez:
4
1
2021
Statut:
ppublish
Résumé
Phenotypic screening of a Medicines for Malaria Venture compound library against
Identifiants
pubmed: 33395287
doi: 10.1021/acs.jmedchem.0c01727
pmc: PMC7816196
doi:
Substances chimiques
Antitubercular Agents
0
Bacterial Proteins
0
Membrane Transport Proteins
0
MmpL3 protein, Mycobacterium tuberculosis
0
Pyrazoles
0
Pyrimidinones
0
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
719-740Subventions
Organisme : Wellcome Trust
ID : 203134/Z/16/Z
Pays : United Kingdom
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