Ceramide mediates radiation-induced germ cell apoptosis via regulating mitochondria function and MAPK factors in Caenorhabditis elegans.

Animals Apoptosis / drug effects Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Ceramides / metabolism DNA Damage Germ Cells / drug effects Mitochondria / drug effects Radiation Radiation-Protective Agents / pharmacology Reactive Oxygen Species / metabolism
Caenorhabditis elegans Ceramide DNA damage response Gamma irradiation Mitochondria function

Journal

Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381

Informations de publication

Date de publication:
15 Jan 2021
Historique:
received: 30 07 2020
revised: 26 10 2020
accepted: 27 10 2020
entrez: 5 1 2021
pubmed: 6 1 2021
medline: 14 1 2021
Statut: ppublish

Résumé

Studies about radiation damage in vivo are very significant for healthy risk assessment as well as cancer radiotherapy. Ceramide as a second messenger has been found to be related to radiation-induced apoptosis. However, the detailed mechanisms in living systems are still not fully understood. In the present study, the effects of ceramide in gamma radiation-induced response were investigated using Caenorhabditis elegans. Our results indicated that ceramide was required for gamma radiation-induced whole-body germ cell apoptosis by the production of radical oxygen species and decrease of mitochondrial transmembrane potential. Using genetic ceramide synthase-related mutated strains and exogenous C

Identifiants

DOI: 10.1016/j.ecoenv.2020.111579 PMID: 33396102
pubmed: 33396102
pii: S0147-6513(20)31416-0
doi: 10.1016/j.ecoenv.2020.111579
pii:
doi:

Substances chimiques

Caenorhabditis elegans Proteins 0
Ceramides 0
Radiation-Protective Agents 0
Reactive Oxygen Species 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

111579

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Yaning Yang (Y)

Anhui Provincial Engineering Laboratory of Water and Soil Pollution Control and Remediation, School of Ecology and Environment, Anhui Normal University, Wuhu, Anhui 241002, China; Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, China.

Guangmin Xu (G)

Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, China.

Yun Xu (Y)

Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, China.

Xiaowen Cheng (X)

Information Materials and Intelligent Sensing Laboratory of Anhui Province, Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, China.

Shengmin Xu (S)

Information Materials and Intelligent Sensing Laboratory of Anhui Province, Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, China. Electronic address: shmxu@mail.ustc.edu.cn.

Shaopeng Chen (S)

Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, China.

Lijun Wu (L)

Information Materials and Intelligent Sensing Laboratory of Anhui Province, Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, China; Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, China. Electronic address: ljw@ipp.ac.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Ceramide mediates radiation-induced germ cell...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Ceramide mediates radiation-induced germ cell...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Caenorhabditis › Caenorhabditis elegans › Ceramide mediates radiation-induced germ cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'helminthes › Protéines de Caenorhabditis elegans › Ceramide mediates radiation-induced germ cell...
questionsmedicales.fr › Lipides › Lipides membranaires › Sphingolipides › Glycosphingolipides › Glycosphingolipides neutres › Céramides › Ceramide mediates radiation-induced germ cell...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Ceramide mediates radiation-induced germ cell...
questionsmedicales.fr › Cellules › Cellules germinales › Ceramide mediates radiation-induced germ cell...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Ceramide mediates radiation-induced germ cell...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Ceramide mediates radiation-induced germ cell...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Radioprotecteurs › Ceramide mediates radiation-induced germ cell...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Ceramide mediates radiation-induced germ cell...